Does Hydrocontin exist?

[skinnykitty]

Does this exist? (I mean like oxycontin - a continuous release of hydrocodone in stead). If it does not, it definitely should.

[Laudaphun]

There used to be a hydromorph contin I thought... perhaps it was just rumor or it was called something else. Once on the street, a kid claimed to have some hydrocontin that was hydrocodone rather than oxcodone... I just figured he had gotten his hands on some hydromorph contin.

SWIM once encountered Codi-Contin surprise surprise. IN a foreign country it came in 60, 90, and 120mg 12-hour time release, but it was dihydrocodeine. The foreign name on the package was Contugesic (SWIM thinks) but was labeled as Codi Contin as it's english name. They were pretty cheap, but this was in Spain (SWIM thinks.. it was a long time ago). In the U.S. SWIM has heard of another contin with regular codeine in em.

LOL but to answer your question SWIM has never heard of or seem anything with a hydrocodone in a time release form. Even though, it is a good idea and we may see such a product some day, you can surely bet it will be schedule 2.

[Allalong]

Swim believes that there is currently an extended release form of hydromorphone (Of the brand name Palladone), but that there is no extended release form of hydrocodone available.

[Orchid_Suspiria]

What would be the point in this anyways?Oxycodone is far better than hydrocodone so why mess with a good thing?

[Laudaphun]

Well there was a brand named Palladone, but i think it might have been taken off the market... Just a little tidbit I found:

We alerted you to the potential for abuse of Palladone (extended-release hydromorphone) in the May
2005 Toxtidbits. As of July 13, 2005, sales and marketing of Palladone have been suspended. A recent
pharmacokinetic study showed that co-ingestion of a 12 mg Palladone capsule with 8 ounces of 40% (80
proof) alcohol resulted in an average peak hydromorphone concentration six times greater than when
taken with water. In some subjects, ingestion of 8 ounces of 4% alcohol (about 2/3 of a typical serving of
beer) resulted in almost twice the peak plasma hydromorphone concentration than when taken with water.
Alcohol disturbs the extended-release mechanism leading to “dose-dumping”, a rapid release of the active
ingredient from an extended-release formulation. This withdrawal is not a recall so existing Palladone™
stocks may still be available. The FDA is advising that patients switch to an alternate analgesic, but some
might continue to take their remaining supply. All patients currently taking Palladone should be
immediately contacted and warned to avoid drinking any alcohol. Patients exhibiting signs and symptoms
of an opioid overdose (lethargy, coma, respiratory depression, pinpoint pupils) due to the co-ingestion of
Palladone with alcohol should be treated with supportive care and naloxone if needed. Keep in mind that

naloxone might induce withdrawal in a patient who has been chronically taking this drug or another opioid.

It's actually pretty interesting I think

[Allalong]

Ahh SWIM had forgotten about that entirely...thank you.

[jerbles]

There could be a continous release of hydrocodone, but if there is I've never heard to it.

[Psych0naut]

Originally Posted by Laudaphun

Well there was a brand named Palladone, but i think it might have been taken off the market... Just a little tidbit I found:



It's actually pretty interesting I think

It's not taken of the market. I know it is prescribed in palliative care, and the Dutch pharmacopeia lists it as well. It is still available in 1,3 and 2,6 mg IR capsules and 4, 8, 16 and 24 mg XR capsules.

[Orchid_Suspiria]

Isn't time released oxycodone far more effective anyways?The only people swim thinks time released hydrocodone would be good for are the opiate naive.

[jerbles]

The only good thing about an XR hydrocodone would be the higher mgs. They would probably go up to 80mg XR (with no APAP). That would be pretty cool, swij wonders what snorting/IVing pure hydrocodone would be like.

[merc11292]

i found a thread on 15mg hydrocodone w/80,100, 200 mg Acetaminophen. On another forum, i dont think i can post the link though. Ive seen links to this site just not to its forum. anyone know if i can post a link to the forum for "pharmer.org" theirs links to it for pill identification, but i think it says somewhere in the rules we cant post other forums if someone can get me a Ok for a moderator il post it.

[imyourlittlebare]

im pretty sure hydromorphone and hydrocodone are two different things. hydro being a prefix to tell you the chemistry of the guy and morphone= morphine and codone=codeine

and oxycodone is stronger than hydrocodone. I think, if my memory serves me correct, hydrocodone is out of your system in 4-6 hours while oxycodone takes about 6-8. and oxycodone , if i remember right is twice as strong as hydrocodone. I think the measurement is something like

1 mg of morphine
10 mgs of oxycodone
20 mgs of hydrocodone
100 mgs of codeine
a shit load of kratom. ha

[Psych0naut]

Actually, 10mg of hydrocodone is equal in strength to 7,5mg oxycodone.

[imyourlittlebare]

oh alright. yeah please, anyone with info readjust my calculator. i think there is a thread on it.

[merc11292]

Originally Posted by imyourlittlebare

im pretty sure hydromorphone and hydrocodone are two different things. hydro being a prefix to tell you the chemistry of the guy and morphone= morphine and codone=codeine

and oxycodone is stronger than hydrocodone. I think, if my memory serves me correct, hydrocodone is out of your system in 4-6 hours while oxycodone takes about 6-8. and oxycodone , if i remember right is twice as strong as hydrocodone. I think the measurement is something like

1 mg of morphine
10 mgs of oxycodone
20 mgs of hydrocodone
100 mgs of codeine
a shit load of kratom. ha

your right with the prefixes and what no but we all know that codeine metabolizes into morphine so in essence hydrocodone metabolizes into hydromorphone and oxycodone into oxymorphone

Actually, 10mg of hydrocodone is equal in strength to 7,5mg oxycodone.


that sounds about right, i think although oxycodone is stronger its out of your system faster hydrocodone is 6-8 hours and oxycodone is 4-6

does anyone actually know what hydro and oxy stand for though, all i learned in school was hydro=water ,whats oxy mean chemically?

[pharmd2011]

Its name is derived from codeine - the chemical structures are very similar, differing only in that the hydrogen on the codeine is oxidized to a hydroxyl group, hence 'oxy' and the hydroxyl group from the codeine becomes a ketone group, hence 'oxycodone.

[pharmd2011]

and oxycodone is 1.5 - 2 times stronger than hydrocodone

[Laudaphun]

I would be very surprised if a time-release hydrocodone is not marketed eventually... The first company that does so will be able to patent it for 7 years or whatever and charge an outrageous price for the duration of those 7 years. Doctors would be getting kick-backs for prescribing it.

As a matter of fact, I believe there are time release versions of almost every other narcotic pain reliever except hydrocodone. Codiene, dihydrocodiene, oxycodone, morphine, hydromorphone, oxymorphone, and fentanyl all come in time-release versions in one country or another.

I'm pretty sure there isn't a time-release available in the mainstream market, but the question I'm wondering is not if, but when.

[ImpalaMan]

there is such thing as extended release hydrocodone... i recently came across some 40mg hydrocodone ER capsules made at saffa compounding pharmacy in tulsa oklahoma. They are very rare but they do exist.

[imyourlittlebare]

Originally Posted by ImpalaMan

there is such thing as extended release hydrocodone... i recently came across some 40mg hydrocodone ER capsules made at saffa compounding pharmacy in tulsa oklahoma. They are very rare but they do exist.

Dunno. It seems like it would be helpful. SWIMS problem when he had mono was that damn hydrocodone helped but only for 4 hours and they wouldnt want to give swim more at this shit hole of a hospital. More interesting story for swim is the problem with constipation. Bladder could have exploded it was filled with 1.5 L of fluid with nowhere to go. Assholes ask swim what they should give swim. They name off all these opioids. Swim says hes on buprenorphine and wants them to know that. Doc doesnt know what buprenorphine is. Looks it up, probably felt like "punk ass thinks he knows better than me" gives swim an injection of buprenorphine even though swim had full dose and there is a ceiling effect already reached for analgesia. Jackasses. Swim got off topic. Mono. Assholes wouldnt give swim 1 pill every 2 hrs to avoid pain. They gave him two pills at a time every 6 hours against his pleads. Luckily, the doctor in outpatient was good (swim was in the hospital for 1 week bc of hesitation to go in). Gave swim oxycodone to take every 6 hrs but swim only needed 1 every 8 which finally allowed swim to get a good nights rest.

While extended release hydrocodone is a good idea, I dont think thats a good idea. Physicians already have extended release morphine at their disposal which is significantly cheaper than any of those other drugs (although hydro is close). I dont know why they dont use that for people who have long lasting pain even if it had acute onset. Its slow release, give someone an immediate release morphine pill, then let the extended release work, keep them on a schedule and no need for any new extended release narcotic.

Maybe its a chemical problem? This is off my head but it lasts from swims subjective pain point 4 hrs with good potency. 5 mg is plenty for pain. But maybe by extending it, one would have a drug with too little potency or too much pharmokinetics, or pharmacy graduates just arent interested in developing it.

Swim went to a pharmacy school. They had an old ass bottle of diacetylmorphine and swim laughed.

[machine_elf]

Just to clarify with the OP, there are no extended release formulations of hydrocodone, but in the UK there is still an extended release formulation of hydromorphone (an active metabolite of hydrocodone) in the form of Palladone SR

Hope this has helped