Alkaloid content of diffrent parts of Papaver Somniferum

[Ontherooftops]

Titre du document / Document title
Comparative qualitative and quantitative determination of alkaloids in narcotic and condiment Papaver somniferum cultivars
Auteur(s) / Author(s)
FRICK Susanne (1) ; KRAMELL Robert (1) ; SCHMIDT Jürgen (1) ; FIST Anthony J. (2) ; KUTCHAN Toni M. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), ALLEMAGNE
(2) Tasmanian Alkaloids Pty Ltd, PO Box 130, Westbury, Tasmania 7303, AUSTRALIE
Résumé / Abstract
In the present study morphinan, tetrahydrobenzylisoquinoline, benzo[c]phenanthridine, and phthalideisoquinoline alkaloids were determined qualitatively and quantitatively by HPLC and LC-MS analysis in tissues of the Tasmanian Papaver somniferum L. elite cultivar C048-6-14-64. The data were compared with the results from the low-morphine cultivar Marianne. In the elite cultivar, 91.2% of the latex alkaloids consist of the three pharmaceutically most valuable alkaloids: morphine, codeine, and thebaine. In the root system, the major alkaloids are sanguinarine/10-hydroxysanguinarine and dihydrosanguinarine/10-hydroxydihydrosanguinarine. In the stems and leaves of C048-6-14-64, the same alkaloids were measured as in the latex. In the stems, a gradient in relative total alkaloid content from the top downward toward the roots was observed. The concentration of morphine was decreasing toward the roots, whereas an increasing gradient from the upper to the lower stem parts was detected for codeine. The relative total alkaloid concentration in leaves remained constant; no gradient was observed. The cultivar Marianne displayed a shifted pattern of alkaloid accumulation and reduced levels of total alkaloid. In the condiment cultivar, 80.5% of the alkaloids of the latex consisted of the two phthalideisoquinoline alkaloids narcotoline and noscapine. Only 18.8% of the relative total alkaloid content were morphinan alkaloids. In contrast to the narcotic cultivar, in which the benzo[c]phenanthridines in roots dominated over the morphinan and tetrahydrobenzylisoquinoline alkaloids, the concentration of benzo[c]phenanthridines in Marianne was similar to that of morphinan and tetrahydrobenzylisoquinoline alkaloids. These data suggest a differential alkaloid regulation in each cultivar of P. somniferum.
Revue / Journal Title
Journal of natural products (J. nat. prod.) ISSN 0163-3864 CODEN JNPRDF
Source / Source
2005, vol. 68, no5, pp. 666-673 [8 page(s) (article)] (27 ref.)
Langue / Language
Anglais
Editeur / Publisher
American Chemical Society, Washington, DC, ETATS-UNIS (1979) (Revue)
Mots-clés anglais / English Keywords
Oceania ; Australia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Papaveraceae ; Pharmacognosy ; Below ground plant part ; Plant origin ; Opiates ; Medicinal plant ; Ultraviolet detector ; Electrospray ; Time of flight method ; Coupled method ; Opium ; Tasmania ; Cultivar ; Isoquinoline derivatives ; Qualitative analysis ; Chemical analysis ; Noscapine ; Plant leaf ; Stem ; Root ; Morphine ; Seasonings ; Mass spectrometry ; HPLC chromatography ; Morphinan derivatives ; Papaver somniferum ; Narcotic analgesic ; Alkaloid ; Quantitative analysis ;
Mots-clés français / French Keywords
Océanie ; Australie ; Spermatophyta ; Angiospermae ; Dicotyledones ; Papaveraceae ; Benzophénanthridine ; Isobenzofuran-1-one dérivé ; Benzo[c]phénanthridine dérivé ; Pharmacognosie ; Partie souterraine végétal ; Origine végétale ; Opiacés ; Plante médicinale ; Détecteur UV ; Electrospray ; Méthode temps vol ; Méthode couplée ; Thébaïne ; Opium ; Tasmanie ; Cultivar ; Isoquinoléine dérivé ; Analyse qualitative ; Analyse chimique ; Noscapine ; Feuille végétal ; Tige ; Sanguinarine ; Racine ; Codéine ; Morphine ; Condiment ; Spectrométrie masse ; Chromatographie HPLC ; Morphinane dérivé ; Papaver somniferum ; Analgésique narcotique ; Alcaloïde ; Analyse quantitative ;
Mots-clés espagnols / Spanish Keywords
Oceania ; Australia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Papaveraceae ; Farmacognosia ; Parte subterránea vegetal ; Origen vegetal ; Opiados ; Planta medicinal ; Detector UV ; Electrospray ; Método tiempo vuelo ; Método acoplado ; Opio ; Tasmania ; Cultivar ; Isoquinoleína ; Análisis cualitativo ; Análisis químico ; Noscapina ; Hoja vegetal ; Tallo ; Raíz ; Morfina ; Condimento ; Espectrometría masa ; Cromatografía HPLC ; Morphinano derivado ; Papaver somniferum ; Analgésico narcotico ; Alcaloide ; Análisis cuantitativo ;
Localisation / Location
INIST-CNRS, Cote INIST : 4127, 35400012470812.0050

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Nº notice refdoc (ud4) : 16830524

[samuraigecko]

like the research, SWIY has done a great job there SWIM does concur. in layman's terms it is saying that the active alkaloids that everyone wants are contained towards the top of the plant in higher concentration. the highest being in the latex etc etc etc, which has been known for centuries. heh.