Up and down regulation of serotonin receptors

[Fantasian]

There is alot of talk about down regulation of receptors due to MDMA or ecstasy use. Meaning due to the receptors being bombarded by the neurotransmitter serotonin the receptors shrink away from the synapse causing a decreased effect of a release of serotonin in the brain leading to a diminished experience if not enough time is given post use. Also it has been noted that post depression people generally feel uplifted and strengthened commonly using the phrase getting thru it made me stronger! Possibly due to up regulation.

Im interested does anyone know how long it takes for up and down regulation to occur on the serotonin receptors?

Are we talking days? weeks? even years?

Im interested for particularly in relation to how long prior to consuming MDMA it would be advised to stop with 5HTP supplementation and if periods of 5HTP supplementation longer than 2 weeks can cause down regulation.