Amphetamine antagonist?

[Freak_]

Is there an antagonist for amphetamines?

Like for example naloxon/naltrexon as an antagonist for opioids or flumazenil as an antagonist for benzodiazepines.

[Psych0naut]

Yes, most anti-psychotics are dopamine antagonist. The newer ones are very selective and useful as an antidote, though their effect is not very pleasant to say the least. Most of the new psychotics are also very selective antagonists for the serotonine receptor on which serotonergic psychedelics act, making them an alround antidote, one of them is Risperidone.

[Freak_]

Yes, I think to let an antagonist work on phenethylamines is not like let work an antagonist on heroin or benzos because it heavily affects the dopamine system.

Yeah risperidone is the ultimate antagonist. It acts as strong dopamine blocker and also as a 5HT2A antagonist.
So if someone comes with an "overdose" or lets say a bad trip on LSD or other tryptamines, risperidone would be a good choice to stop the effects of the tryptamines and phenethylamines also. If someone has the risperidone depot injection (wich is given quite often to schizophrenics) would tryptamines or phenethylamines show any effects?

I read on wikipedia:
The use of antipsychotics on people under the influence of LSD is reportedly extremely unpleasant, with some describing it as a "chemical straightjacket". As a result, Valium is often recommended to reduce the anxiety of a bad trip.
hmm.....i'm asking me why its unpleasant when you get kicked out of a bad trip.

[tayo]

or quetiapine.

[Psych0naut]

The side effects from the anti-psychotics seem to be very unpleasant, though SWIM read an experiment on Erowid somewhere, about a person who took Risperidone in a normal dose(1-4mg) just after taking a psychedelic, and he was back on baseline within 20 minutes, without any side-effects.

Edit:this is the trip report

After I confided in my friends that I think I had a stroke, they told me that I didn't. Jordan explained that I took 4-AcO-DMT. And although that sounded familiar, I didn't quite grasp what it was. Eventually he got the idea to pull up a website to refresh my memory. I remembered that I had some risperidone, which is a HT2a antagonist. I'm not sure how I had the clarity of mind to remember that, but its a good thing I did. I told Jordan to get my some, I took 1mg and within 20 minutes I was basically sober.

Source:Erowid

And another one

One night I dropped four hits of LSD and proceeded to have a very intense trip. About 5 or 6 hours later it was time for me to take my usual dose of Risperdol. I was still tripping very hard, and was not expecting to come down for another 6 hours, but surprisingly enough, I was completely down within half an hour. I should have realized that this was going to happen as Risperdol is in the same class as Thorazine which is used to end bad trips in the hospital.

Source:Erowid