Combinations - 5-HTP, st.john's wort contraindications and run-off periods? - Drugs Forum
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Old 31-07-2007, 01:19
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5-HTP, st.john's wort contraindications and run-off periods?

SWIp$ has used st. johns wort for depresson. SWIp$ has read that st. johns wort should not be used at the same time as MDMA,LSD and a few other seretonogenic psychedelics because of the risk of "seratonin syndrome". pror to reading that SWIp$ recreationally used MDMA whilst taking st. johns wort with noticable effects. SWIp$ also deliberately took st. johns wort in order to intensify the effects of LSA-containing seeds.
SWIp$ thinks that the warnings are based on st. johns wort being catagorised as an MAO inhibitor when infact other studies show its mode of action to be slightly different.
nevertheless SWIp$ has had episodes in the past where after the use of psychedelics he suffers from insomnia insofar as for the next week or so after, meaning SWIp$ can sleep but not as many hours as SWIp$ would like. p$ thinks that in some of these cases this insomnia (rather than the use of psychedelics per se) has led to SWIp$ becoming, shall we say, a little stressed out and unable to think straight. SWIp$ wonders
a) if there should be a run-off period between taking seretonogenic psychedelics/stimulants and resuming st.john's wort, not nescessarily because of the danger of seratonin syndrome but because the st.johns wort is not beneficial in this situation
b) if 5-HT helps in this situation as it is judged to be good for insomnia.
the propreitor of a health supplies business whom SWIp$ considers knowledgeable and trustworthy recommended 5-HTP as a harm reduction measure for MDMA. SWIp$ would be interested in the opinions of those on this forum.
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