Loperamide- efficacy of smoking

[Ontherooftops]

Octopus gave loperamide a go a couple times, it wasn't bad but it really wasn't anything too remarkable. He wonders though, why has no one attempted to smoke this yet? Most opiates can cross the BBB rather rapidly when smoked, loperamide is a fentanyl analog and supposedly fentanyl is very effective when smoked, why wouldn't this be true for loperamide? Octopus will experiment with this if there are no apparent health hazards other than the pretty much garaunteed harsh, nasty smoke.

[Ethyl]

Maybe any of you swimmers who had extracted the loperamide with iso could try this

[csharpprogrammer]

SWIMs extraction product is a powder... should he chase the dragon (heat tin foil with the powder on the tin foil and inhale the fumes) or should he pack a bowl with leaves covered in powder?

[hh339]

Start with a very low amount, and be very careful here.

[Ethyl]

Originally Posted by csharpprogrammer

SWIMs extraction product is a powder... should he chase the dragon (heat tin foil with the powder on the tin foil and inhale the fumes) or should he pack a bowl with leaves covered in powder?

Chase the foil. That way no direct burning and more temperature control. Please report.
At least siwy wouldn't get the pain of snorting and the congestion that swiy did when previously tried to snort.

[Ontherooftops]

Good note SwiHh339. Be wary swimmers, this is a fentanyl analogue and if it has anything close to the potency of fentanyl once across the BBB, it could be rather dangerous.

Swim's octopus will be trying this in the near future. Octopus prefers another method of vaporization to chasing the dragon usually, which can be rather wasteful, and smoking tin foil is always good to avoid. Perhaps using a lightbulb or if any swimmers have one octopus thinks a pookie would work pretty well. That or if the smoke is very harsh, using the knifer through the waterpipe technique.

Please report back with results if any swiy's find the answer.

[csharpprogrammer]

Originally Posted by Ontherooftops

Good note SwiHh339. Be wary swimmers, this is a fentanyl analogue and if it has anything close to the potency of fentanyl once across the BBB, it could be rather dangerous.

Swim's octopus will be trying this in the near future. Octopus prefers another method of vaporization to chasing the dragon usually, which can be rather wasteful, and smoking tin foil is always good to avoid. Perhaps using a lightbulb or if any swimmers have one octopus thinks a pookie would work pretty well. That or if the smoke is very harsh, using the knifer through the waterpipe technique.

Please report back with results if any swiy's find the answer.

SWIM has no naloxone on hand, so he will not try until someone has reported safe results.

[Graduisic]

good thread. looking forward to follow-up information

[hotrod83]

smoking it wont make one bit of difference. It is still the same molecule and wont be able to cross the BBB. Its not like smoking changes the molecules structure.

[csharpprogrammer]

Originally Posted by hotrod83

smoking it wont make one bit of difference. It is still the same molecule and wont be able to cross the BBB. Its not like smoking changes the molecules structure.

SWIM would much rather smoke something than snort it, especially when it comes to this product. SWIM's nostrils burn for 15 minutes and it is a horrible experience that he can't handle. That is why smoking would be better than snorting in this instance.

[paranoid_android]

You guys are all forgetting one important thing. The only reason snorting it is any more plausible than any other route of administration is that the vestigal olfactory system directly links the bloodstream in the brain and nose to a small extent. Unless you inhale the smoke through your nose it's going to be the same thing as eating it or shoving it up your ass.

[crackcityrocker]

today swim did an iso extraction on 24 2mg tablets, smoked off of tinfoil. swim has a pretty high opiate tolerance and did the extraction rather hastily (not to mention some was wasted due to the method of smoking) but does feel some effects. it could be placebo, although i doubt it, but swim will be trying again this weekend, this time smoked out of a pipe on top of some marijuana with his friend and will post the results (with more accurate details) afterwards.

[crackcityrocker]

yesterday swim did an iso extraction of 25 loperamide pills, much more pure than last time. he packed half of the powder in one bowl of marijuana and the other half in another bowl and smoked it all over the course of about 20 minutes. by swim's calculations this should have been a somewhat high dose but the most noticed effects were a stomache ache and slight nasuea. these effects were mostly taken care of by simply laying down, but im not convinced that the buzz swim felt from the loperamide was anything but placebo. swim didnt have a friend to test with to see if they felt anything because everyone swim was with was jigging at the time, so he didnt see any sense in letting them try it.

[tranquillike]

Originally Posted by crackcityrocker

yesterday swim did an iso extraction of 25 loperamide pills, much more pure than last time. he packed half of the powder in one bowl of marijuana and the other half in another bowl and smoked it all over the course of about 20 minutes. by swim's calculations this should have been a somewhat high dose but the most noticed effects were a stomache ache and slight nasuea. these effects were mostly taken care of by simply laying down, but im not convinced that the buzz swim felt from the loperamide was anything but placebo. swim didnt have a friend to test with to see if they felt anything because everyone swim was with was jigging at the time, so he didnt see any sense in letting them try it.

Yes, please let us all know when you are able to float a log.

[Tortoise]

Good luck shitting!

[crackcityrocker]

thankfully no heavy shitting occured.

[0utrider]

any further info on smoking loperamide?

[poozjurry]

swim have smoke today 5x2 mg in 1h in tabak-zigaret with no filters. The effect was very poor. You do net should make this! Its no effective.

[paranoid_android]

Let's put this thread to rest.

Originally Posted by Ontherooftops

Octopus gave loperamide a go a couple times, it wasn't bad but it really wasn't anything too remarkable. He wonders though, why has no one attempted to smoke this yet? Most opiates can cross the BBB rather rapidly when smoked, loperamide is a fentanyl analog and supposedly fentanyl is very effective when smoked, why wouldn't this be true for loperamide? Octopus will experiment with this if there are no apparent health hazards other than the pretty much garaunteed harsh, nasty smoke.

Why wouldn't this be true for loperamide? Fentanyl already crosses the BBB in all other routes of administration. Opiates cross the BBB rapidly when smoked? No, this simply isn't true. The chemical reaches the brain quicker as opposed to most other methods. Once the chemical gets there it takes the same amount of time to cross the barrier.

Bottom line: loperamide does not cross the blood-brain barrier in any significant amount. If swiy wants to put massive amounts of immodium in his system in a vain attempt to get high, save the time and eat them all. At least then when nothing happens swiy won't feel like a complete tool.

Just a half-wit.

[OhCasey]

Originally Posted by paranoid_android

Let's put this thread to rest.




Why wouldn't this be true for loperamide? Fentanyl already crosses the BBB in all other routes of administration. Opiates cross the BBB rapidly when smoked? No, this simply isn't true. The chemical reaches the brain quicker as opposed to most other methods. Once the chemical gets there it takes the same amount of time to cross the barrier.

Bottom line: loperamide does not cross the blood-brain barrier in any significant amount. If swiy wants to put massive amounts of immodium in his system in a vain attempt to get high, save the time and eat them all. At least then when nothing happens swiy won't feel like a complete tool.

Just a half-wit.

The poster you're replying to hasnt posted on this thread in almost a year.

[soma]

It should also be noted that loperamide is NOT a fentanyl analogue, but rather a meperadine/pethidine analogue, a much weaker analgesic, and does not seem to cross the blood-brain barrier with any typical methods of ingestion. It has been administered with nanoparticles of loperamide, coated in polysorbate 80 (more info in another thread), and there is some evidence saying that quinadine may aid in its crossing as well. However, as many others have said, as of now, recreational use of loperamide is out of the reach of most swimmers.

Reputation Comments on this post:

nice contribution, repeat some that was earlier said, new info on administration would be nice

[gotxp]

screw it swim is just gonna try an intracranial injection.. swim is pretty sure what he is doing... the trick is getting a long enough needle

[soma]

SWIM hopes gotxp is joking here.. trying to inject past the blood brain barrier is nearly impossible anyway, you have to use a substance like sucrose to open it, as they do when they need chemo to pass through the BBB. You can't get there by just shoving a needle in your head; its a very delicate procedure that involves carefully metered chemicals to open the membrane and then a carefully titrated dose to achieve the effects. Your best bet would be to synthisize nanoparticles of loperamide via polybutylcyanoacrylate and insulin, and then coat them with polysorbate 80. All of the necessary chemicals can be purchased without suspicion, and this is significently less dangerous than what your suggesting. SWIM has attempted this with some success; an experience report will be posted later. Long story short, the effects were similar to Meperadine for SWIM, not as potent as something like Hydromorphone, but a more pleasant buzz than morphine, albeit not as strong.

[gotxp]

Originally Posted by soma

SWIM hopes gotxp is joking here.. trying to inject past the blood brain barrier is nearly impossible anyway, you have to use a substance like sucrose to open it, as they do when they need chemo to pass through the BBB. You can't get there by just shoving a needle in your head; its a very delicate procedure that involves carefully metered chemicals to open the membrane and then a carefully titrated dose to achieve the effects. Your best bet would be to synthisize nanoparticles of loperamide via polybutylcyanoacrylate and insulin, and then coat them with polysorbate 80. All of the necessary chemicals can be purchased without suspicion, and this is significently less dangerous than what your suggesting. SWIM has attempted this with some success; an experience report will be posted later. Long story short, the effects were similar to Meperadine for SWIM, not as potent as something like Hydromorphone, but a more pleasant buzz than morphine, albeit not as strong.

I totally was not being serious ...

gotxp added 0 Minutes and 56 Seconds later...

rather swim wasnt... I assumed he wasnt serious... that swim is a bit of a nut

[0utrider]

how did SWIY acquire polysorbate 80 ? istn that quite impossible, even combining it with loperamide without a lab ?