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Old 20-07-2007, 10:36
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Lightbulb Turning off SSRI side effects w/ HTP antagonists?

I think I may need to submit the following in my application for the 2008 Darwin Awards. If you think it will turn out to be a winning proposal, I'd love nothing more than an award I could properly display in my sig to note your support. Either way, there's 500 kopecks in it for anyone who helps me sort this chemistry nonsense out.

Here goes:

A respected psychopharmocologist has written that one means of temporarily circumventing the anorgasmia attributed to the use of modern SRI anti-depressants is the occasional timely incorporation of a drug with serotonin antagonist activity into one's romantic life.

The honorable Nom de Plume did not get into one of the other, particularly troublesome side effects of SRI anti-depressants: namely, the end of the Ecstacy.

Do SSRIs block MDMA the same way that buprenorphine blocks full-agonist opiates? I mean (in my simple mind) is the blocking caused by one drug just sitting on the receptors and refusing to allow access to unlicensed trespassers?

If taking a serotonin antagonist could temporarily alleviate serotonin-overload cold fish/soggy hot dog bun syndrome, what is the mechanism? And would that mechanism maybe-possibly allow some MDMA molecules to sneak in, bind, and throw a party for a few hours at the same time?

And yes, I realize that even pondering the idea of taking one drug to temporarily shut down the effects of another drug in the hopes that a third drug will shine through may not earn me the grand prize this year. . . especially since I had the gall to ask a bunch of chemists whether it was feasible.

Darn, must take notes for next year's project.
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5-htp, antagonist, selective serotonin, serotonin, side effects, side-effects, ssri

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