Crystal Meth on Fri/Ecstasy on Sat Night. Will the effects of ecstasy lessen?

[wynter]

I heard when taking ecstacy, you should be clean for a week, not in combination with alcohol, or taking any drugs within a week time frame to make sure ecstacy is at its fullest.

I hear that if you smoke meth, 1 day prior to taking E, the effects of E will be very little because the comedown from the ice is too much to handle, and taking E while your body is replenishing itself, will not take E to its fullest effects. Is this true?

I ask because, Meth releases dopamine, while E releases serotonin. It shouldn't affect each other..

Cheers to anyone who can answer this question.