Drug info - The Great Big Bupropion Thread (Wellbutrin)

[RipperChick]

I stumbled upon a bottle of Wellbutrin 150 mg pills and was wondering (rather hoping) there was SOME sort of hight o be had from them? I've been told no, but maybe if you take a couple? GOD, i miss the Xanax bars..

[OneDiaDem]

No, there is no high to speak of. Its an anti depressant. It also messes with your sex drive.</font>

[twilex]

Word. Just like OneDiaDem said, no high, can mess with your sex
drive, and it gave me wicked headaches every morning. But I'm not
sure if headaches is a side effect of it though, or common.

[Curtains]

i'm going to hve to go against u guys on this one, wellburtin can cause u to trip its an odd antidepressant, not quite like others (read some of the trips on erowid) i've had trust worth friends tell about how they had fucked up trips on wellburtin....but still i woudn't mess with antidressanst becuase its not good to mess with them (sorry a little fucked up right now)

[Micklemouse]

Wellbutrin isn't a Benzo, it's a SDRI - specific dopamine reuptake inhibitor - and it's some nasty shit. Highly dose responsive, so anything above 300mg in 24 hours vastly increases your chances of seizure, heart attack, depersonalisation(very uncomfortable!), panic attacks, the list goes on - the side effect profile of this little baby is about a mile long, and really quite scary! If you take this expecting to get a benzo buzz you'll be very disappointed, as it is a hardcore stimulant and not to be messed with. It's a killer. Do not take it. Please use the search engine and web searches - do your homework!

[PYITE]

i dont want to be preachy but i used to take that stuff in high school and its EXTREMELY DANGEROUS TO MIX WITH ALCOHOL

[computergod]

Ohh I forgot the other method, you can put them up your butt. It works
better then inter-muscular injection, but has no rush like IV
injection. You might not even have to process the pill to do that.

It wouldn't be a bad idea to quickly process the pills:

-crush up 10 of them into hot water
-let it sit overnight
-pour off the water
-give yourself an anal douche

This will give you the runs, so you should 'clean things out' beforehand.


*just noticed that the orgional post was from november* oh well

[Dualpower]

SDRI - specific dopamine reuptake inhibitor

Yikes! I hope they don't actually make those - that would make you feel awful...



Wellbutrin (Bupropion HCl) is an SSRI - "Selective Serotonin Reuptake Inhibitor"</span>



micklemouse still had it right tho .. straying from the prescribed dose
will more likely give you a seizure than a high. Seizures can
potentially kill you, and if they don't, I'm going to assume they suck.



Consider yourself lucky if you've never had to take SSRI's, the side
effects are only worth it if you have a genuine condition. They
certainly aren't useable as a recreational drug.

[Dualpower]

They cause seizures in a portion of the population. I'm not in that,
but you might be.

computergod people like you become statistics. I suppose you just went ahead on a journey of mad discovery to find this out?

Your processing method doesn't make sense to me - one would think the
Buprion HCl would dissolve into the water (if an actual extraction were
taking place) so all you would be sticking up your ass is the binders

It works
better then inter-muscular injection, but has no rush like IV
injection.

How exactly did you inject wellbutrin? I wasn't aware it came in anything other than pill form.

Maybe you're talking about another drug altogether here?

[PYITE]

this is the wrong forum, wellbutrin is NOT A BENZO

[Micklemouse]

Sorry to be pedantic DP, but wellbutrin is a SDRI. Scary but true! It was first formulated in the 60's, long before SSRI's. It's still banned as an antidepressant in Briton, but is used as an aid to stop smoking, with a very limited supply, and under close gp supervision. In the U.S. it seems it's still prescribed as an antidepressant, and seems to be the drug of choice to be given to people kicking coke. It was banned in Briton due to the fact that people kept having psychotic episodes, seizures or dropping dead on it. And yeah, people are extracting the active ingredient and banging it. Fools! Maybe it's a Darwinian thing? I dunno, but it does seem there are a lot of statistics waiting to happen out there!

[computergod]

Your processing method doesn't make sense to me - one would think the
Buprion HCl would dissolve into the water (if an actual extraction were
taking place) so all you would be sticking up your ass is the binders

I meant to keep the water, and toss the filler left behind.

It works on norepinephrine, serotonin, and dopamine. However, it seems
to mostly act on dopamine. The injectable version comes from the link I
provided. The only references to people dieing from it, are from
people who orally took large quantities in suicide attempts. They died
from heart attacks IIRC.

[Micklemouse]

No, they did not! From the Canadian Medical Association...CMAJ • January 8, 2002; 166 (1)
© 2002 Canadian Medical Association or its licensors

PRACTICE

HEALTH AND DRUG ALERTS



Bupropion (Zyban, Wellbutrin SR): reports of deaths, seizures, serum sickness
Eric Wooltorton

Reason for posting: In a letter to health professionals,1 Health Canada and GlaxoSmithKline stated that 1127 reports of suspected adverse drug reactions for bupropion were received between May 1998 and May 28, 2001. Included were reports of 19 deaths (including 1 case of liver failure, 1 case of myocarditis, 3 cases of suicide), 172 reports of seizures or convulsions and 37 reports of serum-sickness-like reactions. Although cause- and- effect relations have not been established in the vast majority of the reports, it is important to remind physicians and warn patients of possible adverse effects of this medication.

The drug: Bupropion appears to block noradrenergic reuptake and dopaminergic reuptake in the brain. It is used as an antidepressant (marketed in Canada as Wellbutrin SR) and as a smoking cessation aid (marketed in Canada as Zyban). Common adverse events include dry mouth and insomnia, nausea, headache and rash.2 Bupropion is known to reduce seizure thresholds, with a seizure rate of about 1 in 1000 subjects treated.3 Anaphylactoid reactions, including dyspnea, angioedema, urticaria and pruritus, have been reported at a rate of 1 to 3 cases per 1000 patients enrolled in clinical trials.2 Symptoms of arthralgias, myalgias and fever and rash resembling serum sickness have been reported rarely. For detailed descriptions of drug interactions and adverse effects, see the product monograph.

What to do: Patients should be warned of the risks of potential serious adverse effects of these medications, including seizures and allergic reactions. Zyban and Wellbutrin SR should not be administered concurrently, nor should they be prescribed to patients with a seizure disorder. Furthermore, bupropion should not be administered to patients with conditions altering the seizure threshold, including anorexia nervosa or bulimia, patients with potential benzodiazepine or alcohol withdrawal, those with head trauma or central nervous system pathology, or patients taking antipsychotic drugs, systemic steroids, quinolone antibiotics or antimalarial drugs. Doses should be limited to no more than 150 mg per single dose and to no more than 300 mg per day. If a seizure or allergic reaction occurs, the medication should be discontinued and appropriate medical attention sought. To avoid prolonged QT intervals and ventricle arrhythmias secondary to thioridazine toxicity, bupropion should not be administered if a monoamine oxidase inhibitor or thioridazine antipsychotic drug has been given within the past 14 days. Bupropion is contraindicated in patients with severe hepatic impairment. A patient information sheet is now available online.4

Eric Wooltorton CMAJ

References

1. Health Canada, GlaxoSmithKline. Important safety information regarding bupropion. July 3, 2001. Available: www.hc-sc.gc.ca/hpb-dgps/therapeut/zfiles/english/advisory/i ndustry/zyban_e.html (accessed 2001 Nov 26).
2. Zyban, bupropion hydrochloride 150 mg sustained release tablets smoking cessation aid [product monograph]. Mississauga (ON): GlaxoSmithKline; 2001 July 5.
3. Hurt RD, Sachs DPL, Glover ED, Offord KP, Johnston JA, Dale LC, et al. A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 1997; 337: 1195-202.[Abstract/Full Text]
4. Health Canada. Safety information for patients taking Zyban. Available: www.hc-sc.gc.ca/hpb-dgps/therapeut/zfiles/english/advisory/i ndustry/zyban2_e.pdf (accessed 2001 Nov 29).

3 out of 19 does not make even a majority, never mind the 'only cases'. For a prescription drug, 16 related deaths(not counting suicides) in 3 years is pretty high, I'm sure you'd agree. You're playing with fire and at the same time spreading misinformation that 30 seconds on google blows out of the water. Please stop!

[Dualpower]

Sorry to be pedantic DP, but wellbutrin is a SDRI. Scary but true!

Wow! My bad! I suppose I should have done my reading first Thanks for correcting me!

At any rate, the sheer volume of scary side effects for OD'ing on this stuff is enough to make snorting it a bad move.

[computergod]

In terms of pharmaceuticals, this stuff has a high amount of side
effects. However, when compared to something like cocaine, its side
effects don't look that bad.

Cocaine example from erowid:

PHYSICAL EFFECTS:

Increases heart rate, blood pressure, body temperature, and sweating.
Increases speed of respiration, dilates the pupils, decreased sleep and
appetite. Can decrease seizure threshold and is associated with
seizures, strokes, and heart attacks in susceptible individuals.

OVERDOSE SYMPTOMS:

Agitation, hostility, hallucinations, convulsions, high body
temperature (hyperthermia), stroke, heart attack, and possibly death.



I'm not saying that its a good idea to do, but its not categorically bad either.

[rd12lude]

I've heard that wellbutrin is good the day after doing coke to kinda take the edge off and help to not want it as much for a few days.Will it take some of the craving away so I won't want to go get a gram EVERYDAY?What would be a safe dosage in mg to take. I have heard that they give seizures so i don't want to take a lot. I have 300 mg XL's I was thinking half would be good, do you think that would be about right? Any help would be appriciated. Edited by: rd12lude

[zipoo]

no expert on this but have taken lost of weelbutrin and think that it offers some protection against cravings of diffrent kind, alcohol, nicitine, so i would assume that although it might not help an addict it can help take th edge off.


however, i would like to know if there are other, cheaper and better alternatives.

[computergod]

300mg is the usual dose for nicotine withdrawal.

[upperdecker]

SWIM had no idea where to put this thread. If SWIM were to parachute Wellbutrin will it have the same effects if it is snorted?

[upperdecker]

Anyone, does anySWIY's at all know? And yes SWIM has looked numerous places for the answer but hasn't found it.

[Micklemouse]

Please explain what parachuting means

[upperdecker]

Originally Posted by Micklemouse

Please explain what parachuting means

Crushing it up like it is about to be snorted but instead wrapped in a little piece of toilet paper and swallowed.

[upperdecker]

Noone can answer this? SWIY gonna make SWIM do it to find out?

[Bio-Cellular Enigma]

Since when has Wellbutrin been considered 'recreational'? This is news to SWIM. His research and/or experience suggests irritability, edginess and tendency to anger for little or no reason -- it's a mostly unpleasant stimulant with no appreciable euphoria, much like drinking too many cups of coffee. Unless used as an antidepressant, why risk seizures for such paltry returns?

To answer the question -- no, 'parachuting' it will not have the same effects as snorting. It won't clog SWIY's sinuses with brightly colored goop, won't produce copious sneezing, nor will it result in blowing chunks of undissolved tablet into a kleenex for the next few days.

P.S. SWIM sometimes 'parachutes' tablets, but he prefers chewing them up and swallowing (with a glass of water for chaser, of course). Perhaps there are no "real men" left anymore .

[Bajeda]

I find it ironic that the Most Desperate Thing Done To Get High thread came up right under this one in New Posts when I clicked it a few moments ago.

Why on earth would you want to parachute wellbutrin?