DPT and cross tolerance

[Fantasian]

Ive had a bit of a search and couldnt find the answer easily. I understand that tripping 2 days in a run causes a greatly diminshed experience second time around. But SWIF is planning on doing a 3 day camp. He would like to trip consectutively on 2 days. On the first day he will be tripping with DPT,

1) he would like to know is redosing possible with DPT?
2) he would like to know if he wanted to trip on a second day with DPT what increase of dosage should he use? (insufflation is his route of admin)
3) WOuld there be an advantage in using a differant tryptamine on the second day like 4-HO-DIPT etc.

[samadhi_smiles]

There will definitely be less tolerance with another chem (cross-tolerance we call it). This is because each individual chemical affects a different profile of HT (serotonergic) receptors. This accounts (along with chronology and any other mechanism of action such as monoamine release) for their different character.

There will be a diminished second experience. Part of the usage of an HT agonist entails a necessary short term receptor downregulation (think the receptors shrink up into the membrane wall). Excessive abuse leads to a longer term downregulation.

I would suggest tripping once and using the subsequent day to integrate the experience. If SWIY's camping there will hopefully be enough wonderful and amazing nature to occupy SWIY and keep your thoughts focused where the trip took place.

Trying to adjust dosage (ie increase) for tolerance has never resulted in a satisfying trip for SWIM and friends.

PS DPT combines fantastically with the 4-sub-Ts SWIM has tried (4acoDMT and 4HODMT).

[Silverbackman]

So I guess DPT is inferior to DMT since it has a short period of tolerence. DMT seems almost like the perfect psychedelic........the only problem is its short duration.

[TMM]

Originally Posted by Silverbackman

So I guess DPT is inferior to DMT since it has a short period of tolerence. DMT seems almost like the perfect psychedelic........the only problem is its short duration.

Well, that's where Ayahuasca comes in, although I suppose MAOI interactions might be less 'convenient' than tolerance.

[Nagognog2]

It is generally accepted that DMT is not cross-tolerant with LSD, Mescaile, Psilocybin, etc. But I've yet to read any studies regarding DPT and such. SWIM make be in new territory.

[Fantasian]

SWIF has a couple of answers to his own questions.
1) Redosing is possible on DPT and does recreate a peak effect however the duration is significantly reduced possibly even halved at the same dosage.

2) an Increase of dosage the following day increases the intensity of effects as though no previous tolerance was existant but the duration is still shorter like with redosing.

3) Mixing 5-Meo-MIPT and DPT makes for a very intense peak if taking simultaniously however if one is taken after the other the second tryptamine has very little effect and also reduces the effects of the other.

SWIF will be doing more research between these 3 and will add it when found.

[samadhi_smiles]

Be careful about increasing dosages to combat short term tolerance. This is subjecting already sensitive receptors to more 'trauma' which will result in longer downregulation.

My best advice is to go slow with it.

[UberDouche]

SWIM has found that 50mg DPT HCl mixed with MET freebase and insufflated at the same time produced quite a nice experience. SWIM will be attempting the 2nd day in a row with this today. SWIM will keep you posted as to any tolerance.

[EDIT]: And yes, SWIM found the experience essentially the same 24hours later with all parameters being the same (10mg MET, 50mg DPT)

SWIM also wanted to add that an experiment was performed whereby 10mg MET was gently sprinkled on bowl of mj and smoked in that manner. Definately had an effect. Not like smoking DMT, but very definatlely more going on there than mj. Will require further assays, says SWIM.