Opiate Tolerance Question

[Corksil]

SWIM has searched, and he cannot find this. It seems to be a very simple question -- How rapidly does an opiate tolerance build?

SWIM knows that everyone's body is different, but is there a ballpark guess or an equation involving BMI, bodyweight, etc? Does tolerance build at different speeds to different opiates?

How about cross tolerance between opiates? If anyone could shine a light into this dark corner, SWIM would be very grateful.

SWIM understands it's a good idea to wait 7 days between psychedelic experiences, so the brain can replenish seratonin levels sufficiently for a strong trip. Are opiates similar?

[Orchid_Suspiria]

There just really isn't much of a ballpark estimate.And what opiate is swiy reffering to?How frequent is the use and how is it used?

[weekender2]

As SWIOrchid says, it's kind of all over the map, depending on body size, personality, and opiate type - but consider this: if SWIY is high every day for a week on the dope of his preference, he's either a good way down the road to addiction, or he's already there.

SWIM forgets who said it first here on this forum, but it's absolutely true: opiates make a wonderful lover but a terrible mistress. Do SWIY'self a favor and keep her at arm's length. Play with 'em too much and SWIY're the one to get played.

Pax,
Weekender

Reputation Comments on this post:

very helpful post

[Orchid_Suspiria]

It sounds like swimystereo2099 might be a beginner to the opiate world,and take it from swim who is far past beginner that swiy might be getting in over their head.

[Corksil]

SWIM has dabbled in several different opiate substances. SWIM is currently referring to his turtle's morphine sulfate oral solution. The turtle tried 20mg today, about 1.5hrs ago, and notices little but noticeable effects. The turtle ate 10mg of Methadone on Wednesday the 4th, today is the 8th. He consumed food 40 minutes prior to ingestion of the 20mg, and about 10fl oz of a beverage containing citric acid. (He thinks this might have affected the pH in his stomach, which would break down the morphine sulfate quicker and produce less of an effect.) He consumed carisoprodol 2 nights ago, but only 350mg and he drinks lots of water to help flush the chemicals out of his turtle body.

SWIM's turtle is 140lbs, about 6foot tall when he stands on his hind legs. Does the aforementioned make sense? Thanks for prompt replies

[Orchid_Suspiria]

Morphine tolerance develops pretty quickly,it will vary from person to person ofcourse but daily morphine use for a week would result in tolerance.

[Corksil]

This would be the first time the turtle has tried morphine. Would the turtle using methadone 4 days prior have to do with the tolerance? The turtle's friend did 20mg of morphine sulfate, and he was glued to the couch drooling for 7 hrs. Why does the turtle notice barely any effect? The turtle also ingested a multi-vitamin 16 hrs prior, which he thinks may have some inhibiting chemicals in it.

For turtle's next experience, he will wait until next weekend to rule out tolerance (he is skinny and has decently fast metabolism and drinks lots of water.) He will try the same dosage, possibly rectally, though if oral with the addition of tums. Turtle does not want to OD, but he wants strong effects.

The turtle told SWIM to tell SWIY that he appreciates the opiate advice. No one is above the influence. SWIM will tell the turtle to be very careful. Thanks for info!

[tayo]

Methadone can have an extremely long terminal half-life, up to 190 hours. It likely had something to do with it, and also the fact that different turtles respond differently to different drugs. With morphine, for potentiation... it might be beneficial to UTFSE to research grapefruit juice. It could increase bioavailability about 3x the amount considering morphine's ~32%(ish) bioavailability. Obviously it would be best to familiarize the turtle with the compounds before potentiation. Also remember that it would be like 60mg, so tolerance will increase accordingly to bioavailability.

[SpaceCadetGlow]

Swim was faced with the same problem SWIstereo's turtle is having. Methadone has a terrible and lesser-known side effect. While one is taking sufficient amounts of methadone (>10 mg) , one cannot experience the euphoric effects of any other opiate. It took swim a full ten days of abstinence from methadone before other opiates could even begin to be felt.

[Psych0naut]

Fentanyl raises ones tolerance much, much faster than normal opiates and opioids. The stronger semi-synthetic also raises tolerance quicker. SWIM read that the strongest fentanyl derivatives actually destroy mu-opioid receptors, they pull the receptors through the endoplasmatic reticullum, destroying them. SWIM has read this about carfentanyl and ohmefentanyl, but he doesn't know if the lower potency fentanyl derivatives like a-methylfentanyl and fentanyl itself do alot or even any damage to the mu-opioid receptors.

[Corksil]

Very interesting to read, Cadet. SWIM now understands more fully why it is given to those trying to quit. Long tolerance = more one has to spend on other things etc, less chance of relapse due to tolerance etc... interesting.

Thanks Psych0naut for the information, it was very helpful.