Health - The pineal gland and DMT

[flipthecandy]

Does the pineal gland produce DMT? I have heard some reports say it does, and some say it doesn't, does anybody know the truth? If so, is it possible that when you die you release an extremely large amount of DMT, and are transported to DMT land? I have read many trip reports about elves, and specifically elves noticing the tripper there, and communicating with them as to say 'i am surprised you are here'. mayeb because you are still alive? What are your thoughts?

[tayo]

it is found there, no doubt. it would seem as though it is produced there and what you are saying sounds possible. maybe you've read this already? http://sprott.physics.wisc.edu/Pickover/pc/dmt.html

[flipthecandy]

I've read that but still am not sure. what i'm saying is like our minds leaves the physical realm. DMT is a naturally occuring chemical, after all

[tayo]

yes, like an out of body experience. maybe it's the brain's last attempt to save the body with happiness and growth hormone for repair, since growth hormone levels rose equally in response to IM injections of DMT. or the body's biological method of dying happy

[BackToBasics]

The pineal gland, as Budgie believes (could be slightly wrong), does not directly create DMT..it's a series of conversions in the brain that actually produce the DMT...

Tryptophan - Serotonin - Melatonin - Pinoline - 5MeoDMT - DMT

The Pineal gland releases MAOI inhibitors in the sleeping hours to enable this conversion to 5-meo-DMT and DMT to take place.
Budgie's always thought that ingesting DMT was a shortcut to the dream experience, directly to the subconscious, but that doesnt explain the many common elements to peoples trip reports, such as meeting other beings.

A good place to start if swiy is interested in the 'Elves' and such, is the writings of a certain Terence McKenna.

[Lehendakari]

I don't think there is scientific proof of DMT being secreted by pineal gland. I think only a hypothesis, pineal gland is known to produce melatonin and other tryptamines, so it may have traces of DMT as a byproduct, but I don't think DMT presence in the body has been proved, neither disproved..

Many drugs provide similar effects and are not related to DMT pharmacologically sp? so IMO it is a bit unwise to call dmt spitit molecule.

Even the biggest expert in neurology and neurophamacology is still far way from understanding brain functioning and brain bio-chemistry

[BackToBasics]

Originally Posted by Lehendakari

Many drugs provide similar effects and are not related to DMT pharmacologically sp? so IMO it is a bit unwise to call dmt spitit molecule.

Well, Psilocybin (4-ho-DMT) is related, which other drugs did swiy mean? Plus, it is possible for chemically unrelated drugs to have the same pharmacological action, so maybe it's just that DMT isnt the only 'Spirit Molecule'.

[Lehendakari]

Originally Posted by BackToBasics

Well, Psilocybin (4-ho-DMT) is related, which other drugs did swiy mean? Plus, it is possible for chemically unrelated drugs to have the same pharmacological action, so maybe it's just that DMT isnt the only 'Spirit Molecule'.

No. Ketamine, PCP, DXM, Salvinorin-a they all have different pharmacology and different chemistry yet induce similar states.

Of course, every drug is unique in it's effects and subjective for every user.

[Yukio Mishima]

Originally Posted by Lehendakari

but I don't think DMT presence in the body has been proved, neither disproved..

The excretion of the hallucinogen dimethyltryptamine (DMT) and its precursor N-methyltryptamine (NMT) was studied among 74 recently admitted psychiatric patients and 19 normal persons. Both compounds were detected in 24-hour urine samples from all subjects. Dimethyltryptamine excretion was greatest in schizophrenia, mania, and "other psychosis" and tended to decline as clinical state improved. Psychotic depressives excreted smaller amounts of DMT more akin to those excreted by neurotic and normal subjects. Urinary NMT excretion was unrelated to psychiatric diagnosis. Ratings on the Present State Examination (PSE) also indicated that increased excretion of DMT was associated with psychotic rather than neurotic psychopathology. Forty-three percent of the variance in urinary DMT levels could be explained in terms of six of the 38 PSE syndromes. Syndromes suggesting elation, perceptual abnormalities, and difficulty in thinking and communicating were most correlated with raised urinary DMT excretion.

http://archpsyc.ama-assn.org/cgi/con...tract/36/6/644

Reputation Comments on this post:

Good find! Please add more

[Heretic.Ape.]

Most thought on this stems from Strassman's theory which was verrrry tenous. Not a convincing argument if you read it, but very interesting. Many people have latched on to this idea and given it undo validity because an MD came up with it. Strassman never claims that it is a fact or even that there is overwhelming evidence pointing toward this, only a somewhat convoluted conjecture.

[Lehendakari]

^^ Interesting, however it'd be good to find information about presence of DMT within the brain and even better in the pineal gland.

I only could find this about 5-meo-dmt in sheep's pineal gland:

Article
Analysis of 5-methoxytryptamine in brain by gas chromatography mass spectrometry

Olof Beck, Talmage R. BosinDepartment of Toxicology, Swedish Medical Research Council, Karolinska Institule, S-104 01 Stockholm, Sweden
5MT = 5-methoxytryptamine; 5MeO-DMT = 5-methoxy-N,N-dimethyltryptamine; HIOMT = hydroxyindole-O-methyltransferase; PFPA = pentafluoropropionic anhydride; PFP = pentafluoropropionyl.
setDOI("ADOI=10.1002/bms.1200060105")
AbstractA quantitative gas chromatographic mass spectrometric method using a deuterated analogue as internal standard was developed for the analysis of 5-methoxytryptamine in brain. The internal standard was synthesized in two steps and possessed high isotopic purity. The analytical procedure involves the addition of the internal standard to the homogenizing medium containing the tissue, followed by homogenization, extraction with chloroform and derivatization with pentafluoropropionic anhydride. The identification and quantitation of 5-methoxytryptamine is based on monitoring the ions at m/z 306, 319 and 482 for the pentafluoropropionyl derivative of 5-methoxytryptamine and m/z 308, 322 and 486 for the internal standard. Using this procedure 5-methoxytryptamine was identified and quantitated in the sheep pineal gland. The mean 5-methoxytryptamine level (N=12) was 545±180 pmol g-1.

http://www3.interscience.wiley.com/c...63867/ABSTRACT


If anybody can find more information post it here.

Reputation Comments on this post:

interesting find. thanks for sharing

[sunyata]

I don't have time to look for it myself right now, but you want this:
N,N-Dimethyltryptamine: An endogenous hallucinogen. by Barker SA, Monti JA, Christian ST.
Int Rev Neurobiol 1981;22:83-110

[Swimster]

check this out: http://www.drugs-forum.com/forum/sho...&highlight=dmt

also, dmt is theorized to be secreted naturally durring nde's(neer death experiences), in which one's "life flashes before them", and they "see the light". also believed to be secreted durring heavy rem sleep.

[Nagognog2]

Put down your scalplel and and your capsules of Harmaline. The brain produces VERY small amounts of n,n-Dimethyltryptamine. No - squeezing your head in a vice won't make more. Nor will tossing your Breville Juicer full of fresh pineal glands. Even if you attempt to picrate the juices of same them afterwards.

SWIM wants DMT? Look into MHRB Tek extraction. That's likely the easiest way to go. Now shush! Before Bush sends his Republikan Guards racing across the land conducting Patriotic Surgery on people they think have Big Heads.

[Tryptamine]

Even without sufficient scientific evidence, SWIM is certainly convinced that N,N-DMT is produced naturally in the human. The fact that meeting intelligent entities during the experience is a recurring, universal motif further convinces SWIM, since during SWIM's own night-time dreams this occurs very strongly quite often. Also, upon rising from a deep, pre-sleep consciousness at night, SWIM experiences colorful tryptamin-esque visual distortions for up to a minute before fully regaining consciousness. These two bits of experiences are enough to be convincing. And supposing that the chemical's presence is fully validated someday...I think the notion that it plays a crucial role in deep-sleep and dreaming cognitive processes and that it plays a role in the enlightening pre-death state make it deserving of some scientific and religious attention from society. Who knows, maybe it is possible that N,N-DMT was an intentional means of communication between real existing entities and humans for guiding purposes and such.

[flipthecandy]

Originally Posted by Tryptamine

Who knows, maybe it is possible that N,N-DMT was an intentional means of communication between real existing entities and humans for guiding purposes and such.

That is my theory. A hard one to prove at that! Further exploration and experimentation will occur when SWIM either gets his hands on some DMT or moves out and makes his own!

[Swimster]

Before Bush sends his Republikan Guards racing across the land conducting Patriotic Surgery on people they think have Big Heads.

LOL.

Yea, becarefull, our pennial glands may become scedule 1!

-everyone would do time!