Info on oripavine?

[Ontherooftops]

Octopus is quite curious about the action of oripavine on its own. He is aware it is a step in making some stronger opiates, and is the basis for buprenorphine, but has read some interesting things about the action of oripavine on its own.

Octopus found something stating 4mg/kg had similar analgesic action to .5mg/kg morphine. He wishes his understanding of organic chemistry and pharmacology were better. He has also read some things saying that oripavine has some antagonistic action on opiod receptors...

It seems there is some addiction potential as well, demonstrated by self admin in monkeys.

Would oripavine be safe to assay, would it make swim's octopus unhappy?

Do any SWIYs know about this substance?

[Pino]

Originally Posted by Ontherooftops

Octopus is quite curious about the action of oripavine on its own. He is aware it is a step in making some stronger opiates, and is the basis for buprenorphine, but has read some interesting things about the action of oripavine on its own.

Octopus found something stating 4mg/kg had similar analgesic action to .5mg/kg morphine. He wishes his understanding of organic chemistry and pharmacology were better. He has also read some things saying that oripavine has some antagonistic action on opiod receptors...

It seems there is some addiction potential as well, demonstrated by self admin in monkeys.

Would oripavine be safe to assay, would it make swim's octopus unhappy?

Do any SWIYs know about this substance?

My cat wasn't sure about octopuses, he likes to eat them. Never asks questions, but he told me that rats died by convulsions when they were giving 5mg/kg and rhesus monkeys survived 5.6mg/kg, but were also convulsing. It stopped, when they were injected with morphine. It sounds a lot like thebaine to my cat. So it seems to be a no-go area. Source

Specific quote from source:

Gross behavioural observation

Rat
The gross behavioural effects of intravenous single doses of oripavine were observed in normal rats. The minimal effective dose was 0.24 mg/kg; the spontaneous motor activities were lost immediately after administration. The maximal tolerable dose was 4 mg/kg, at which dose the animals showed pre-convulsive disorders such as hyperirritability, tremor, muscle rigidity, motor impairment and transient muscle contraction. These signs lasted more than one hour after administration but the rats survived. At 5 mg/kg, however, the rats died immediately after administration in a persistent tonic seizure [ 2] .
Rhesus monkey
Yanagita conducted a gross behavioural observation of the acute effects of oripavine in rhesus monkeys by subcutaneous administration of the drug at single doses of 0.06, 0.25, 1 and 4 mg/kg, using saline as the control agent under a blind procedure. The mininal effective dose was 1 mg/kg, and at this dose the monkeys manifested a decrease in spontaneous motor activity, occasional eye-closing, vomiting and tremor. These effects lasted for less than two hours. At 4 mg/kg, vomiting and tremor were exaggerated, and hyperirritability to sound stimuli, motor impairment and pre-convulsive disorders were observed for about 1.5 hours after administration [ 2] . Harris administered oripavine to a rhesus monkey at a cumulative subcutaneous dose of 5.6 mg/kg over 45 minutes (0.8, 1.6 and 3.2 mg/kg at 15-minute intervals) and observed severe tremors which were terminated with pentobarbital and morphine [ 3] .

It is not strange it is similar to thebaine, because -another quote- the dependence potential of thebaine is at least partially attributed to oripavine which is one of the principal metabolites of thebaine.