Combinations - Possible problems and interaction between cocaine use and SSRIs ?

[Kolon]

Are there any associated problems using coke when on SSRIs?

[tayo]

i dont think so. look it up though. cocaine's primary neurotransmitter target is dopamine, and SSRIs are for serotonin... possible mood lift? if it were something like a wellbutrin that works on dopamine it could be different

[CocaineCrazy]

I'm in for some scientific information on it.

[Benga]

will look into it. In the meantime, since swim is really not reference on SSRIs, will try forwarding this thread to the SSRI forum.

[Abrad]

Here's a couple of abstracts which may be of interest.

Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine

Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbens.

Molecular Mechanism of Citalopram and Cocaine Interactions with Neurotransmitter Transporters

[Kolon]

Originally Posted by Abrad

Here's a couple of abstracts which may be of interest.

Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine

Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbens.

Molecular Mechanism of Citalopram and Cocaine Interactions with Neurotransmitter Transporters

Thanks buddy but is that a yes or a no?

[Raw edge]

Swim has reported no problems.

[Practical_Toker]

sounds like no, no problems, it just makes it even better

[Paracelsus]

Cocaine is a potent reuptake inhibitor of dopamine, norepinephrine and serotonin (mainly dopamine though). While SSRIs would most likely increase serotonin-related euphoria from cocaine (although the euphoria is mainly caused by dopamine reuptake inhibition), caution should be advised with large amounts of cocaine, binges or (worse) addiction with chronic use, as thes could cause serotonin syndrome (through significant serotonin reuptake inhibition).

[Jay Lith]

SWIM tried cocaine 4 times, 2 of which whilst taking an SSRI as well. Had no problems with it - they didn't appear to interact - also no come down. Swim took a little line each time. Bear in mind drug effects can vary a lot from person to person though!

I'm v. interested in getting info on interactions between prescription mood drugs and recreational drugs. can't find much info even on erowid. Anyone know where to look?

[toe]

They both lower the seizure threshold, which increases the risk exponentially rather than additively. Prior experience not required- the vast majority of grand mal seizures in adults are experienced by tonic clonic virgins.