Extraction - exposing vendor secrets... how to isolate 7-Hydroxy-Mitragynine?

[tayo]

If anyone has any info or experience on creating an ethanol based isolate of mitragynine, or 7-hydroxy-mitragynine, please post here. some vendor out there is isolating it why can't the people who aren't us isolate it?

[snapper]

Mitragynine is isolated via fractional distillation, but to isolate 7HO, it needs to be synthesized from mitragynine. This is why 7aco exists - it is an intermediate in the process...

[tayo]

hmm okay, but just curious... since mitragynine could be isolate why couldn't 7-ho-mitragynine be isolated since it also naturally occurs in the plant. and this fractional distillation, does anyone have a procedure to follow to do this?

[snapper]

Because they are nearly impossible to separate due to similar distillation temps and the small ration of 7HO relative to mitragynine. SWIM does not have the details, but looking up melting and vapor points of the two compounds as well as their relative proportions in the plant should reveal the reason. SWIM discovered this when inquiring as to the origins of the 7ACO and subsequently found it it was synthesized - why ? to make 7HO. However, there may be other ways to separate these two, but it is probably easier to convert it.

[Alfa]

This topic is intriguing as this may shed some light on why most Kratom extracts are so shitty.

[neonfyr]

Most extracts are so shitty, because they are not standardized, and many of them are waterbased ( water is a poor solvent for the actives )

=)

[snapper]

Not the one SWIM tried. Grain alcohol based and very standardized. SWIM found it highly effective. SWIM is sure there are lots of inferior products out there since it is not a trivial process to ectract and purify / synth the actives. Most used to come from one source and are resold / repackaged - maybe now there are more labs producing in. SWIM has not looked into it for a while since SWIM stopped using the plant.

[realfolkblues]

This whole bit about freebasing with Isop, Naptha and Sodium bicarb. Is this a viable way to extract alkies?

[ajm48786]

Swim really hopes the vendors do not isolate it; and sell the alkaloid by itself, it will become illegal very fast

[neonfyr]

Yes it is sold. However it's too expensive to isolate, so chemists actually create the compound from the far more plentiful compound mitragynine.

Thanks,
Matthew

[AceOvArts]

SWIM tried 7-ho-m and 7-aco-m

SWIM thought they were both rubbish and a waste of money.

[jux]

this was taken from another forum...i think it is relevant to the topic at hand...

Originally Posted by Nalim

I actually talked with some people on the ***** about this.
This is what I gathered from a bit of serching online articles and papers:

Here is something of great interest:
http://www.jstage.jst.go.jp/article/cpb/52/8/916/_pdf
p. 924

Mitragynine + PIFA (phenyliodine bis(trifluoroacetate)) in aqueous CH3CN --> 7-Hydroxymitragynine

It says they where expecting 50% yields, but then they stray, they don't state the actual yields but I assume they got the expected.

And here is an article that has an isolation technique.
http://mitizane.ll.chiba-u.jp/metadb...1/Y2006-17.pdf
It uses a chromatography column to separate the different alkaloids.


Here's some other close relatives and how to make them, take a close look at the synths here as they are really close to what will be used for making 7-Hydroxymitragynine

http://pubs.acs.org/subscribe/journa...?sessid=6006l3

7-hydroxy-10-fluoromitragynine
7-hydroxy-10-chloromitragynine
7-hydroxy-10-bromomitragynine
7-hydroxy-10-methoxymitragynine