Combinations - what drug combinations are absolute no-nos?

[gib]

SWIM is not talking about drug combos that result in a bad trip. SWIM is talking about drugs that, when mixed together in the same body, have some kind of adverse chemical or biological reaction (worse case scenario: drug A + drug B = acid that'll eat right through all your guts). SWIM would suspect that the body has a natural defense against any foreign agents coming together to form leathal compounds and such, but one never knows for sure. Anybody know of any for-sure no-nos?

[asdasdasd]

well, dxm+stimulants or mdma+other stimulants could result in strokes....

[Swimster]

various/multiple antidepressants, and mdma, etc. Anything that causes a lot of serotonin to flow. also, multiple/various downer, aswell as uppers. Or a single substnce: Datura!

[toe]

Lithium and, you know, pretty much anything.

[Orchid_Suspiria]

Corricidn Cough and Cold,it is actually a combination.Dxm and the antihistamine cpm.And swim knows from personal experience that combining this with a stimulant,namely cocaine is a very dagernous thing that should never be done.Triple c's shouldn't be done at all but to combine them with stimulants is even worse.

[tayo]

usually it is no downers + uppers, or no downers + downers, or no uppers +uppers... swim thinks its usually best to not mix different types of drugs anyway, although there are some exceptions made by swim to that.

[gib]

This is all good to know

[augentier]

Cocaine + Alcohol creates another chemical within the body (forgot its name exactly...ethylsomething? it's all over the Cocaine & Crack thread) and from what I understand, it puts enormous strain on the heart.

[Swimster]

Originally Posted by augentier

Cocaine + Alcohol creates another chemical within the body (forgot its name exactly...ethylsomething? it's all over the Cocaine & Crack thread) and from what I understand, it puts enormous strain on the heart.

cocaethylene

[asplinteredfawn]

Originally Posted by augentier

Cocaine + Alcohol creates another chemical within the body (forgot its name exactly...ethylsomething? it's all over the Cocaine & Crack thread) and from what I understand, it puts enormous strain on the heart.

SWIM says something that went alone the lines of:

Cocaethylene?!? Yes it does put strain on your circulatory system / cardiovascular. But unless you're like 8 years old, 50 and above or have a heart condition, your unlikely to die form this combination. It's actually a combination that should be under " best combos" along w/ d-amphetamine and scotch.

If you keep your body healthy; exercise, eat correctly and don't have any preexisting conditions, you will MOST LIKELY be fine mixing alcohol and cocaine. But SWIMS not saying there aren't risks. But your pretty much putting your self at risk by drinking alcohol or snorting or smoking cocaine/crack in the first place.

People can be so asinine about chemicals, it's like banning smoking in bars. Being safe is one thing and SWIM thinks people that post harm reduction literature are great ( including the person typing this ), but when bringing foreign toxic chemicals into your body you're always putting your self at risk. Your bartering or giving currency hoping to acquire a powder, pill, liquid, or whatever form it may be in; from usually a perfect stranger or one of your friends and if your friend is selling drugs he probably hasn't read up on much biology, Bio-chemistry or pharmacology...; let alone any Oscar Wilde or... hell even Chuck Palahniuk, who is quite popular these days.

What Swim is saying can be summed up by saying that " If you're putting your self at risk, by even accepting an 8 ball of cocaine or a 5th of Johnny Walker Red. Don't be afraid to mix stimulants with downers now and then in moderation if you're healthy and young. Especually cocaine and ethanol; ( Cocaethylene... SWIM wishes you could buy that straight up and slam that w/ some raw. ) So take a walk on the wild side babe."

Just SWIMS opinion if you choose to stop being a common cultural joke of the young generations then it is not anyones fault but your own.

Knowledge is a pathway to safety but pretending to be knowledgeable and really existing in this state of " reality " with pseudo-knowledgeable " pseudo-facts " , often leads to limited experience and generally silliness.

[JDreaming]

-Do not take LSD if using lithium unless you think "seizuring" is a good look and a cool style for the future.

-If you are on SSRI or MAOI medication, assume your meds will adversely cross-react with everything. Don't try a thing until you've read how your meds react and ruled out the possibility of a deadly cross-reaction.

-Do not drink alcohol or carbonated beverages with amanita muscaria mushrooms. Unless maybe you're bulimic and violent vomiting is your idea of a fun day.

-If you must use GHB, do not ever drink alcohol with it. Particularly nasty downer/downer combination with threat of death involved.

That's all I can think of off the top of my head.

Reputation Comments on this post:

best post of the thread

[Electric Wizard]

Originally Posted by JDreaming

-Do not take LSD if using lithium unless you think "seizuring" is a good look and a cool style for the future.

-If you are on SSRI or MAOI medication, assume your meds will adversely cross-react with everything. Don't try a thing until you've read how your meds react and ruled out the possibility of a deadly cross-reaction.

-Do not drink alcohol or carbonated beverages with amanita muscaria mushrooms. Unless maybe you're bulimic and violent vomiting is your idea of a fun day.

-If you must use GHB, do not ever drink alcohol with it. Particularly nasty downer/downer combination with threat of death involved.

That's all I can think of off the top of my head.

Ketamine and alcohol for the same reason. It can slow your heart to a stop.
The amount of people SWIM has seen violently throwing up on this combination is crazy.

[Twiglet]

swim thinks it should be pointed out, that, like mao medication, mao inhibitors is the active bit of ayahuasca brews, he's thinking of stuff like Banisteriopsis caapi , syrian rue. etc

• Foods High in Tyramine (to be avoided):
  • All aged/mature cheese (exception: cottage cheese, cream cheese)
  • Dry and fermented sausage (bologna, salami, pepperoni, corned beef, and liver)
  • Pickled herring and salted dried fish
  • Broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans)
  • Meat extracts
  • Yeast extracts/brewer's yeast
  • Beer and Ale
  • Red wine (chianti, burgundy, sherry, vermouth)
  • Sauerkraut
  • Banana Peel
• Foods Moderate to Low in Tyramine: (to be used in limited amounts, i.e., 1/2 cup, 4 oz. or less)
  • Fruits (bananas, avacados, canned figs, raisins, red plums, raspberries)
  • Cultured dairy products (buttermilk, yogurt, and sour cream)
  • Chocolate
  • Caffeine (coffee, tea, and cola drinks)
  • White wine, port wines
  • Distilled Spirits
  • Soy sauce
  • Peanuts
  so you don't want to be eating any of this stuff a good few days before ayahuasca (not sure how long) any ideas anyswim's?

[Pino]

Originally Posted by twiglet

• so you don't want to be eating any of this stuff a good few days before ayahuasca (not sure how long) any ideas anyswim's?

The plasma half-time should be really short, because the stuff is break down almost immediately. SWIM couldn't find the half-life in humans, but in dogs it is 4 minutes. So SWIM thinks a day should be fine, but the more days is better. Unless someone's labrat is accidentally a labdog.

PS: MDMA and cocaine together sucks. A really funny looking bird told me, it is a total waste of two fine products.

[sci]

viagra n poppers are a no no .just what i tread

[frankpikins]

Well swim should watch out when mixing maois and other substances together.

suprised no one said this earlier!

[Probing Tranquility]

SWIM has done the coke and mdma and doesn't recomend it. The coke seems to kill the mdma buzz, and all the dangers of taking a combination of stimulants, plus the variance in the content of E pills.

[Twiglet]

Originally Posted by frankpikins

Well swim should watch out when mixing maois and other substances together.

suprised no one said this earlier!

They did, but like all good info it's scatered randomly around the forums and net, and all seem to have different lists of things to avoid.
swim thinks this is why a lot of tribes fast (don't eat anything) days before ayahuasca.
before swiy takes anything new they should research it first. erowid has a site thats good or at the lyceaum.
read some trip reports.
this info will help a lot , although noone can't be sure what you got is genuine.

[Twiglet]

sorry , double post

[Twiglet]

Also swim knew someone who had a cocktail and died!
he had been drinking a lot, probably lager, he injected (I.V) a lot of amphetamine this was common for him. he then decided to I.V ketamine.
YOU DO NOT I.V KETAMINE, it is for I.M use.
he then had asthma attack , he used his ventalin inhaler, he turned blue in front of his girlfriend and died.
apparantly, according to inquest he died of a reaction between Ketamine+Ventalin.

[Twiglet]

If this is right and it was only those two (Ketamine + Ventalin) that killed him then swim thinks it should be thread starter. all K-heads should know

[gib]

All this stuff is really good to know. I recommend a sticky on this one.

So anyway, I really have my doubts that the following combination is at all leathal, but just for the sake of SWIM's own sense of security...

SWIM often does weed*, caffein, and alcohol in combination. SWIM has never had any adverse effects to this (except a bit of paranoia that it might be fucking with his system), but recently SWIM has got a sample of kratom. SWIM would like to try weed* and kratom in combo. Anyone know of any adverse reactions of these two. Again, I serious doubt there's any worry, but one can never be too cautious about one's health.

It's actually not weed that SWIM is smoking, but a combination of a whole bunch of things called "spice" (legal high sold out of the UK). It's got the same effects as weed.

[JDreaming]

There's a pretty significant difference between spice and weed, in my opinion. And spice contains so many different ingrediants it is almost impossible to predict the adverse effects it would have in combination with kratom, or anything else. You really can't just consider spice to be functionally the same as cannabis. It contains no cannabis and it's effects are distinctive and different to many of the people who use it.

[Bio-Cellular Enigma]

Two powerful stimulants, such as cocaine and methamphetamine, at the same time. As with two strong 'downers' such as benzodiazepines and alcohol, the effects of two uppers will potentiate each other, leaving the user highly vulnerable to stroke, heart attack, aneurisms, seizures, paranoia, panic attack, psychosis and all manner of nasty occurrences.

Of course things are occasionally mixed, but usually amounts are disproportionate (e.g. very small amount of amphetamine mixed with larger amounts of ecstasy or cocaine).

Luckily, people generally have the common sense not to mix two strong stimulants together. For example, SWIM has never heard of even the craziest "tweaker" attempting to inject methamphetamine and cocaine at the same time.

[Broshious]

Originally Posted by Bio-Cellular Enigma

For example, SWIM has never heard of even the craziest "tweaker" attempting to inject methamphetamine and cocaine at the same time.

That gives SWIM an idea...