Combinations - what drug combinations are absolute no-nos?

[gib]

SWIM is not talking about drug combos that result in a bad trip. SWIM is talking about drugs that, when mixed together in the same body, have some kind of adverse chemical or biological reaction (worse case scenario: drug A + drug B = acid that'll eat right through all your guts). SWIM would suspect that the body has a natural defense against any foreign agents coming together to form leathal compounds and such, but one never knows for sure. Anybody know of any for-sure no-nos?

[asdasdasd]

well, dxm+stimulants or mdma+other stimulants could result in strokes....

[Swimster]

various/multiple antidepressants, and mdma, etc. Anything that causes a lot of serotonin to flow. also, multiple/various downer, aswell as uppers. Or a single substnce: Datura!

[toe]

Lithium and, you know, pretty much anything.

[Orchid_Suspiria]

Corricidn Cough and Cold,it is actually a combination.Dxm and the antihistamine cpm.And swim knows from personal experience that combining this with a stimulant,namely cocaine is a very dagernous thing that should never be done.Triple c's shouldn't be done at all but to combine them with stimulants is even worse.

[tayo]

usually it is no downers + uppers, or no downers + downers, or no uppers +uppers... swim thinks its usually best to not mix different types of drugs anyway, although there are some exceptions made by swim to that.

[gib]

This is all good to know

[augentier]

Cocaine + Alcohol creates another chemical within the body (forgot its name exactly...ethylsomething? it's all over the Cocaine & Crack thread) and from what I understand, it puts enormous strain on the heart.

[JDreaming]

-Do not take LSD if using lithium unless you think "seizuring" is a good look and a cool style for the future.

-If you are on SSRI or MAOI medication, assume your meds will adversely cross-react with everything. Don't try a thing until you've read how your meds react and ruled out the possibility of a deadly cross-reaction.

-Do not drink alcohol or carbonated beverages with amanita muscaria mushrooms. Unless maybe you're bulimic and violent vomiting is your idea of a fun day.

-If you must use GHB, do not ever drink alcohol with it. Particularly nasty downer/downer combination with threat of death involved.

That's all I can think of off the top of my head.

Reputation Comments on this post:

best post of the thread

[Swimster]

Originally Posted by augentier

Cocaine + Alcohol creates another chemical within the body (forgot its name exactly...ethylsomething? it's all over the Cocaine & Crack thread) and from what I understand, it puts enormous strain on the heart.

cocaethylene

[Twiglet]

swim thinks it should be pointed out, that, like mao medication, mao inhibitors is the active bit of ayahuasca brews, he's thinking of stuff like Banisteriopsis caapi , syrian rue. etc

• Foods High in Tyramine (to be avoided):
  • All aged/mature cheese (exception: cottage cheese, cream cheese)
  • Dry and fermented sausage (bologna, salami, pepperoni, corned beef, and liver)
  • Pickled herring and salted dried fish
  • Broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans)
  • Meat extracts
  • Yeast extracts/brewer's yeast
  • Beer and Ale
  • Red wine (chianti, burgundy, sherry, vermouth)
  • Sauerkraut
  • Banana Peel
• Foods Moderate to Low in Tyramine: (to be used in limited amounts, i.e., 1/2 cup, 4 oz. or less)
  • Fruits (bananas, avacados, canned figs, raisins, red plums, raspberries)
  • Cultured dairy products (buttermilk, yogurt, and sour cream)
  • Chocolate
  • Caffeine (coffee, tea, and cola drinks)
  • White wine, port wines
  • Distilled Spirits
  • Soy sauce
  • Peanuts
  so you don't want to be eating any of this stuff a good few days before ayahuasca (not sure how long) any ideas anyswim's?

[Twiglet]

Also swim knew someone who had a cocktail and died!
he had been drinking a lot, probably lager, he injected (I.V) a lot of amphetamine this was common for him. he then decided to I.V ketamine.
YOU DO NOT I.V KETAMINE, it is for I.M use.
he then had asthma attack , he used his ventalin inhaler, he turned blue in front of his girlfriend and died.
apparantly, according to inquest he died of a reaction between Ketamine+Ventalin.

[Twiglet]

If this is right and it was only those two (Ketamine + Ventalin) that killed him then swim thinks it should be thread starter. all K-heads should know

[gib]

All this stuff is really good to know. I recommend a sticky on this one.

So anyway, I really have my doubts that the following combination is at all leathal, but just for the sake of SWIM's own sense of security...

SWIM often does weed*, caffein, and alcohol in combination. SWIM has never had any adverse effects to this (except a bit of paranoia that it might be fucking with his system), but recently SWIM has got a sample of kratom. SWIM would like to try weed* and kratom in combo. Anyone know of any adverse reactions of these two. Again, I serious doubt there's any worry, but one can never be too cautious about one's health.

It's actually not weed that SWIM is smoking, but a combination of a whole bunch of things called "spice" (legal high sold out of the UK). It's got the same effects as weed.

[JDreaming]

There's a pretty significant difference between spice and weed, in my opinion. And spice contains so many different ingrediants it is almost impossible to predict the adverse effects it would have in combination with kratom, or anything else. You really can't just consider spice to be functionally the same as cannabis. It contains no cannabis and it's effects are distinctive and different to many of the people who use it.

[Bio-Cellular Enigma]

Two powerful stimulants, such as cocaine and methamphetamine, at the same time. As with two strong 'downers' such as benzodiazepines and alcohol, the effects of two uppers will potentiate each other, leaving the user highly vulnerable to stroke, heart attack, aneurisms, seizures, paranoia, panic attack, psychosis and all manner of nasty occurrences.

Of course things are occasionally mixed, but usually amounts are disproportionate (e.g. very small amount of amphetamine mixed with larger amounts of ecstasy or cocaine).

Luckily, people generally have the common sense not to mix two strong stimulants together. For example, SWIM has never heard of even the craziest "tweaker" attempting to inject methamphetamine and cocaine at the same time.

[Broshious]

Originally Posted by Bio-Cellular Enigma

For example, SWIM has never heard of even the craziest "tweaker" attempting to inject methamphetamine and cocaine at the same time.

That gives SWIM an idea...

[frenchywife]

MDMA and Meth - worst trip ever - thought SWIM was going to die and the ill after effects lasted for days (i.e., tingling in left arm and hand, dizzy, and extremely toxic!)

[Expat98]

Another one is Viagra and poppers (alkyl nitrates). The two of these together can cause blood pressure to drop to a dangerously low level or trigger a heart attack. A lot of guys use Viagra to offset the "lazy willy" effect of other drugs like MDMA or meth. Just remember not to throw poppers into the mix too.

Reputation Comments on this post:

nice addition; but it's alkyl nitrites, not nitrates.

[tayo]

yeah that's a good point, vasodilators should be taken into consideration. like the weightlifting supplement, NOXplode. which L-arginine increases NO levels and acts as a vasodilator.... and yeah that would suck to die while huffing a popper right as you had an orgasm... what a way to go out.

[Expat98]

That got me wondering about combining L-arginine with Viagra, since I may try L-arginine as a daily supplement in the near future. I found this about the subject:

Q. Can L-arginine and Viagra be taken together?

A. Though the sexual benefits of using Viagra and L-arginine are
similar, their mechanisms of action differ. Both Viagra and L-arginine
carry contraindications (cautions/warnings) for use. Improperly
formulated L-arginine formulas can cause mild to severe medical
problems. Viagra users are cautioned not to use nitrates and nitrites
in conjunction with Viagra. Nitrates are indiscriminate on venous
pooling and arterial compliance, but arginine is utilized where
its mechanism of action is required. Therefore, it is not likely
that arginine would cause hypotension when taken with Viagra,
but not totally impossible, particularly when other medications
(such as nitroglycerin) are used which disrupt homeostatic blood
pressure mechanisms and when there is pre-existing severe coronary
and/or cardiovascular disease.

The current published DRUG INTERACTIONS state "At this time,
there are no well-known drug interactions with arginine."

Bottom Line:
Until further data is available, it is best to avoid taking Viagra
at the same time as L-arginine. Caution would dictate taking L-arginine
at least 2 hours apart from ingesting Viagra. Consult with your
physician for further instruction.

(See http://www.anndeweesallen.com/L-ARGI...0Article-2.htm )

Reputation Comments on this post:

nice, good post

[Pino]

Originally Posted by twiglet

• so you don't want to be eating any of this stuff a good few days before ayahuasca (not sure how long) any ideas anyswim's?

The plasma half-time should be really short, because the stuff is break down almost immediately. SWIM couldn't find the half-life in humans, but in dogs it is 4 minutes. So SWIM thinks a day should be fine, but the more days is better. Unless someone's labrat is accidentally a labdog.

PS: MDMA and cocaine together sucks. A really funny looking bird told me, it is a total waste of two fine products.

[sci]

viagra n poppers are a no no .just what i tread

[frankpikins]

Well swim should watch out when mixing maois and other substances together.

suprised no one said this earlier!

[Probing Tranquility]

SWIM has done the coke and mdma and doesn't recomend it. The coke seems to kill the mdma buzz, and all the dangers of taking a combination of stimulants, plus the variance in the content of E pills.