Methadone question

[maximumquake]

A friend of mine took 40mg of methadose(oral methadone). My freind came across an oc 80 today and he was wondering if he did the oc 80 would he feel it. My freind's question is how long does methadone opite blocking qualities last and how long does methadone last in general. My friend was also wondering if my friend was to do the oc 80 tonight and not feel it, how long should he wait until he should do the oc 80 so he can feel it. My friend would appreciate any responses. Thank you

[Orchid_Suspiria]

This would be extremely dangerous,40 mg of methadone along with an 80 mg oc is a huge does of opiates even for a regular user.If swiy's friend took it he might not feel it but it's other effects would come on and might just put swiy's friend six feet under.It sounds like some people really shouldn't be playing with very grownup substances.

[MrJim]

Methadones half-life in the body is 24-36 hours. That means 24hrs later about 20mg of methadone would still be active in the body. Doing opiates night after night isn`t really a good idea anyways.
So yeah, your friend should not do it. And 80 is a large dose if naive t opiates.

Reputation Comments on this post:

well said

[beentheredonethatagain]

MrJim is exactly correct. Methadone is very dangerous due to its long half life. many of overdose was caused by a build up of Methadone in the users system. After the feeling of the drug has worn off , there is still the toxicity if you will remaining in the blood.
This fact of half life is the reason nobody ever stops or are unable to quit the methadone program. They get trapped.
Methadone is also used in pain managment , but should be avoided . MS is a much better option.

[asplinteredfawn]

Taking opiates while on methadone is a waste and methadone for most people is a hellish existance that is very hard to escape. Honestly stick to heroin or try suboxone.

[Wflash]

This question was a posted some time ago, but in case it's relevant to anyone else - not all methadone contains ingredients to block the action of other opiates. At least I don't think it does. SWIM has never been told that his should do that and it certainly doesn't appear to. If your friend was to take that much of SWIM's meth the additional drugs would be an additional opiate effect over and above that of the meth.

[SpaceCadetGlow]

If nitro's friend only took methadone one time, he should probably wait 3-4 before taking any other opiate with hopes of feeling the opiate's effects. However, if nitro's friend was taking methadone on a regular basis, a full ten days of abstinence from methadone is usually required before other opiates can be felt.

In response to Flash - methadone is methadone. Any compound containing methadone will have an opiate blockade effect. Nothing is added to methadone preparations to achieve this blockade. It's the methadone itself that causes this.

Therefore, oxycodone on top of methadone will not add to the methadone's effect. It will only be a waste of oxycodone. In addition, if the dosages were to be 40 mg methadone and 80 mg oxycodone, combining these drugs in such large amounts could be dangerous.

[tayo]

So in other words, what you're saying is that methadone is a competitive agonist and has a higher affinity for opiate receptors than (most) other opiates. Is that what you meant by "opiate blockade effect"? Because if the receptors are all full, then there's no room left.



a skit!
"You can't come in Mr. Morphine, this is my receptor!" said Mr. Methadone.
Mr. Morphine responded with "aw fuck man!"
*sneaks hand in opiate doorway... *SLAM
"Ouch!" cried Mr. Morphine.
"Serves you right, I told you this is my receptor... bioootch! It's just going to have to stay there now, I feel bad for you so I'm going to let a little part of you stick around." Mr. Methadone chuckles... knowing he is superior.



Other little facts..
It's half life is typically 15-60 hours and up to 190 hours (rare).

It does have a certain affinity for antagonizing NMDA receptors, and other NMDA antagonists are known to have certain anti-addictive properties.

[Orchid_Suspiria]

Swim isn't so sure about all this.Swim remembers taking methadone and later afternoon taking 60mg's of morphine sulphate and he did feel the morphine aswell as the methadone.He also remembers taking methadone one day and the very next doing two bags of h.He didn't feel the h as strongly as he might have usually but he certainly felt the effects.

[tayo]

Yeah, I wouldn't say there are no effects if methadone is taken and x opiate is added. My friend said there were, it may have some blocking effect though, just because it's taking up space in the opiate receptors, the blocking is probably more noticeable at higher doses too. My friend imagines that 80mg of morphine added to 80mg of methadone would have little bonus morphine effect.

[Orchid_Suspiria]

Swim knows methadone has a blocking effect.Swim has discovered that for some individuals it might not be as extreme as many believe it is.Swim can attest to this because he has been a longtime methadone user and has combined methadone with many other substances both opiate and non opiate.

[SpaceCadetGlow]

Swim apologizes for making the generalization that he did regarding methadone. Swim was surprised to hear about SWIorchid's experience with morphine sulfate after methadone; until now he's only heard of methadone nullifying all other opiates. Swim is glad to have learned this and is reminded that everyone's body reacts differently to substances.

Also, when swim had his experience with methadone's blocking effect, he had just ended a week of daily methadone use. Obviously, the drug would have been much more concentrated in swim's body and likewise the half-life much longer.

Orchid - I would love to rate your post, but even after reading up on it in the FAQ, I can't figure out how to rate posts/threads. Help me help you help us both?

[tayo]

As a newbie I believe you are not allowed to rate posts, but once you make silver member there will be an icon like this next to the . Clickt the scales icon.

[SpaceCadetGlow]

Ah. Thanks Tayo. I guess what's I'm looking for is that upgrade to silver.

[Wflash]

Methadone may indeed be methadone, but I'm increasingly convinced that what is prescribed in the UK is different in a number of ways to that which is prescribed in the US. Even SWIM's doctor doesn't reckon that the liquid 1mg to 1ml methadone prescribed to him has any opiate blocking effect. He warns him that taking additional opiates on his meth script would be very dangerous etc. etc. (as he is bound to do) as it would have an effect over and above.

Is there anyone on here who has experience of methadone use on both sides of the Atlantic I wonder?