Combinations - has anyone combined lsd with maois, tricyclics or lithium?

[The Wizard]

Does anyone have experience combining LSD with MAOI's (such as Syrian Rue, Deprenyl, etc), Tricyclics or Lithium? If so I'd like to hear about your experiences. SWIM once combined a high dose of Lithium with a tenstrip and had a nightmarish trip that lasted days and days and resulted in a 2 week stay in the mental ward. SWIM also on another occasion combined 4 or 5 grams of Syrian Rue with a few blotter squares and had a pleasant, mellow trip.

[tayo]

this post contains errors, read a couple posts down for clarification.... bold [bracketted] are additions to original
just a note, tricyclics are [not] MAOI's. [some MAOIs are] pharmaceutical grade and some are suicide inhibitors [an inhibitor that permanently deactivates an enzyme and is therefore eliminated from the body because it has been rendered useless], which supress activity for sometimes two weeks. swim hasn't tried mixing it with LSD though.

Reputation Comments on this post:

thanks for clearing up your post

[Micklemouse]

Originally Posted by tayo

just a note, tricyclics are MAOI's, pharmaceutical grade and some are suicide inhibitors, which supress activity for sometimes two weeks. swim hasn't tried it though.

What? That makes no sense whatsoever Tayo. Firstly Tricyclics are not MAOI's - they are 2 seperate classes of antidepressant.

Secondly

some are suicide inhibitors, which supress activity for sometimes two weeks.

sounds like they can suppress suicide for 2 weeks!

[eltimmy]

MAO-B doses of Selegiline did not significantly alter SWIM's response to LSD. SWIM would caution strongly against taking any MAOIs with the more sympathomimetic research chemical psychedelics ... (mostly phenethylamines)

Lithium has been reported on erowid to strongly increase the effect of psychedelic drugs (as opposed to SSRIs, which seem to attenuate them), and also to provoke seizures when taken in combination with them: check the experience reports for the combination.

[tayo]

sorry was mixed up with info on tryciclics and MAOIs, but there are mao inhibitors that last like 2 weeks, and thats why up to ~two weeks after the last dose people are told not to have tyramine. yeah its not daily dosed, pretty sure.

and "suicide inhibitor" means that it deactivates the enzyme permanently and subsequently, it leaves the body, should have clarified a bit for thos unfamiliar with term. haha not that it inhibits you and makes you commit suicide...no no no

[tayo]

here this is from wikipedia....

so some....

The early MAOIs inhibited monoamine oxidase irreversibly. When they react with monoamine oxidase, they permanently deactivate it, and the enzyme cannot function until it has been replaced by the body, which can take about two weeks. A few newer MAOIs, notably moclobemide, are reversible, meaning that they are able to detach from the enzyme to facilitate usual anabolism of the substrate. The level of inhibition in this way is governed by the respective concentrations of the substrate and the MAOI.

[Jatelka]

There is an article in the archive here...

http://www.drugs-forum.com/forum/loc...d=343&catid=32

On this exact same topic

"Chronic tricyclic administration was associated with subjective increases in physical, hallucinatory and psychological responses to LSD. Subjects taking Lithium also reported increased effects. Subjects chronically taking an MAOI reported subjective decreases in the effects of LSD"

[little carrot]

Mao, sure,(always been a bit of a communist sympathiser) tricycles, why not, it's been a while, Lithium, no way, sister was on that stuff in highschool and it made her spend thousands of dollars on pet fish and she also adopted a paraplegic guinea pig. And yes, perhaps acid had something to do with it all. perhaps not.

[Nagognog2]

Another thread touches on this quite strongly:

http://www.drugs-forum.com/forum/sho...247#post277247

[toe]

Danger, Will Robinson! Grand Mal Seizure Ahead!

[MADali]

Hi folks, first post here,

So this is about my cousin's friend's brother's boss' sister's boyfriend, who I think is called Eel Adam.

Anyway, Adam, from what I heard, lives in a place where LSD is very difficult to get by, so when he got a supply of them, he trips once a week only. Because he doesn't want them to get over so fast, he has looked into any interesting combinations, but it seems almost everything reduces the effect.

Except it seems Lithium, according to this forum, the usenet posts, and erowid. From what Adam read, this combo can be anything from double the acid effect to seizures. But Adam decided to try it anyway. Rumor has it that Adam is in a safe enviroment, at home, surrounded by people, and so on. Adam took tab of acid, and also one lithium pill (400 mg, Camcolit). After an hour, the effect did seem more pronounced, but it could also just have been placebo effect. After an hour, he took another pill, but no seizures or manic atacks yet.
Now, let me mention that Adam is not ON these pills. He got them several months back for a case of depression, but he stopped taking them after a week.
I thought maybe you guy's can find the above useful, as there seems to be a lot of strange stories regarding this combination. From what I know, Adam is at home now, listening to music, and drinking red wine, so if I hear anything new and interesting about his night, I'll be sure to inform you.

[smiz]

I've never heard anything about doubling the effect of the acid. I always thought the two combined (acid and lithium) only had potential of being fatal? Maybe you have to be a regular user of lithium. Maybe I just don't know enough about it. Anything new from your night?

[MADali]

You can find some info anecdotes here:

http://www.erowid.org/chemicals/lsd/lsd_health3.shtml

I think it depends on if you take it daily, not just with the LSD.

[Jatelka]

There is some evidence that lithium enhances the subjective effects of LSD, although, as already pointed out, this is only in chronic users of Lithium

Bear in mind though, that noone actually knows Lithium's mode of action, and it is a remarkably toxic drug, even on it's own, with a hefty adverse effects profile:

gastro-intestinal disturbances, fine tremor, renal impairment (particularly impaired urinary concentration and polyuria), polydipsia, leucocytosis; also weight gain and oedema (may respond to dose reduction); hyperparathyroidism and hypercalcaemia reported; signs of intoxication are blurred vision, increasing gastro-intestinal disturbances (anorexia, vomiting, diarrhoea), muscle weakness, increased CNS disturbances (mild drowsiness and sluggishness increasing to giddiness with ataxia, coarse tremor, lack of co-ordination, dysarthria), and require withdrawal of treatment; with severe overdosage (serum-lithium concentration above 2 mmol/litre) hyperreflexia and hyperextension of limbs, convulsions, toxic psychoses, syncope, renal failure, circulatory failure, coma, and death; goitre, raised antidiuretic hormone concentration, hypothyroidism, hypokalaemia, ECG changes, and kidney changes may also occur.

(Shamelessly copy n pasted from the BNF)

Unless one has to take Lithium (and it does seem to suit some people well) this really isn't something that should be pissed around with

Reputation Comments on this post:

Good information concerning lithium

[Zaprenz]

Originally Posted by Jatelka

Lithium (and it does seem to suit some people well) this really isn't something that should be pissed around with

SWIM would second that point.

Lithium is not a drug to be taken lightly & it seems a rather bad choice for extending ones possibilities with a given amount of LSD.

[Ezy Ryder]

SWIM have combined 30mg mirtazapina and 100mg nortriptyline with lsd with no problems, maybe too agitation. But with shrooms have become very paranoid and weird and no "triping".