Snorting - Everything SWIY Needs to Know About Snorting Benzodiazepines

[moda00]

Anyone have any either firsthand experience, or factual knowledge backed up by research, regarding the different modes of benzo administration? Swim's always taken orally and had the desired effects.. but she wonders about sublingual vs. oral, and how the actual dosage/absorption differs.. as well as if crushing/parachuting pills orally as opposed to swallowing them in tablet form is more effective.. She recently underwent "conscious sedation" procedure for some dental work, took 10mg diazepam the night before, .25 mg midazolam orally/swallowed at 6am, plus a 0.5 clonazepam for good measure. arrived at dentist at 7am, hooked up to nitrous, and was then given another .25 midazolam within the half hour, only this time they crushed it and had her take sublingualy. These were the same pills- not two different versions for different methods of ingestion.. so how would this compare? Swim was apparently conscious and fine during the procedure, but remembers hardly anything, so she can't really shed much light on the comparison between the two different routes.. thanks for any input..

[Donmeka]

SWIM has snorted xanax on many occasions just because he enjoys snorting tings lol he has felt rushes when insufflated but also tells others it is almosst if not 100% worthless and SWIM also prefers popping his bars

[Solinari]

As far as i know, midazolam is the only water soluble benzodiazepine that exists (there may be one or two other obscure ones i don't know about), so i imagine sublingually would be similar to snorting.

Personally i don't think snorting would work very well for most benzodiazepines, but if some people think they get instant effects then who i am to say they don't. Never the less, i think the majority of the effects come from it eventually being swallowed and the faster onset could be a result of the pill being crushed up.

[jj_redick_stud4]

Originally Posted by Herbal Healer 019

If SWIy is looking 4 a better "buzz" or what hav u, cut the bar into 4 peices & snort 1 square & titrate dose from there. Insufflation will work better bcuz it increases bioavailability (amount able 2 reach the blood stream), but has its downsides. Snorting pills can damage the nasal cavity because most pills contain fillers (waxes, etc..), & aren't freebase. Most pharmaceutical pills are x_substance HCL (hydroclhoride), meaning it is acidic (i.e bad as hell 4 the nasal cavity). If SWIy chooses 2 snort, make sure the outer coating has been removed.

SWIM is assuming the zanny bars are 2mg. Cutting the bar into 4 peices will increase the absorption rate simularly to chewing the pills & will hit faster most likely.

Snorting xanax like most benzos barely do anything if not nothing at all when snorted except the drip that goes to your stomach, which would be like just taking it orally. Most benzos are not water soluble or barely water soluble which means that it won't absorb well in your mucas membrane that are in your nose. If you want more absorbtion of the drug plugging it is the best way and it absorbs very well orally to. BTW SWIM took 3 bars, 1 30 mg temazie,and has been smokin weed so he said he's really fucked and is sorry if grammar and puntuation is off.

Reputation Comments on this post:

very true... thats what I was thinking

[gmeziscool2354]

yeah, This class of drug usually is not in the HCL salt form. and it is also not soluble in water. the liver hydroxylates them, at least in the case of alprazolam (xanax). Interestingly Alprazolams hydroxylized component is also psychoactive, which is very interesting.

snorting xanax would actually be less efficient than oral administration.

[fiveleggedrat]

Originally Posted by jj_redick_stud4

Snorting xanax like most benzos barely do anything if not nothing at all when snorted except the drip that goes to your stomach, which would be like just taking it orally. Most benzos are not water soluble or barely water soluble which means that it won't absorb well in your mucas membrane that are in your nose. If you want more absorbtion of the drug plugging it is the best way and it absorbs very well orally to. BTW SWIM took 3 bars, 1 30 mg temazie,and has been smokin weed so he said he's really fucked and is sorry if grammar and puntuation is off.

Snorting benzos works. Snorting not working is a myth. And no, it's not like taking it orally. Ground pills go into the sinus cavity and absorb through veins there. It hits quicker, lasts shorter, and avoids first pass metabolism. It is not the mucus membrane in the nose that absorbs drugs. And plugging is not effective for all benzos, and this is experience talking. It's usually weaker than oral.

fiveleggedrat added 1 Minutes and 3 Seconds later...

Originally Posted by 90%.

take on an empty stomach!

And yes, benzos seem much more potent on an empty stomach, and definitely take effect much quicker.

[Herbal Healer 019]

Originally Posted by fiveleggedrat

Snorting benzos works. Snorting not working is a myth. And no, it's not like taking it orally. Ground pills go into the sinus cavity and absorb through veins there. It hits quicker, lasts shorter, and avoids first pass metabolism. It is not the mucus membrane in the nose that absorbs drugs. And plugging is not effective for all benzos, and this is experience talking. It's usually weaker than oral.

I thought so, AFOAF has snorted diazepam & he reported it to have worked well. He says it was a long time ago but thinks it was weaker than oral an oral dose but isn't sure.

Can't seem to find the bioavailabilty of the various routes of administrations with alprazolam, other than a simple 80-90% which I assume to be oral.

It would help if some1 posted the bioavailability of various benzos with the various routes of administration.

[chronman]

swim has a couple questiong about klonopin and soma.

is it possible to make either of the drugs snortable/smokeable by boiling/soaking in something acidic, like lemon juice or vinigar? can they be reduced in pill size by letting them sit in isopropyl alcohol or acetone? is that more snortable/smokeable? and will the result be more effective than standard oral dose?

also, can swiy effectively vaporize the active chemical in soma or klonopin? how many mgs are needed to catch a "rush" from inhaling?

[jj_redick_stud4]

"A drug that is snorted or snuffed is taken in through the nose, where it is absorbed through the mucous membranes lining the nasal passages." (National Institute of Health; http://science.education.nih.gov/sup.../lesson3-1.htm; in section titled Drugs Enter the Body in Different Ways. So yes when SWIY snorts something it is absorbed through the mucous membranes and SWIY might be right about it absorbing in your throat for SWIM hasn't any knowledge in that area. When someone snorts something the drip that's swallowed is absorbed in their stomach. http://www.drugs-forum.com/forum/showthread.php?t=3372 here's a thread for SWIY where it explains that because xanax isn't water soluble when snorted it is POORLY absorbed. SWIM never said it wouldn't do anything he just said pretty much that it's a waste of a bar, burns the nose really bad, and is the worst tasting pill. So it's dumb to SWIM however this is just SWIM's opinion and SWIY could disagree even some of SWIM's friends are addicted to snorting and will snort just about anything which there's nothing wrong with it SWIM guesses if SWIY likes it but it's scientifically proven that snorting xanax and most benzo is an ineffective administration of the drug compared to other methods. When taken orally it's the slowest method for it to absorb in the bloodstream and sometimes so long that the enzymes in your digestive system start breaking down the drug so it can be cleared from the body however the absorption rate in xanax is from 94-100%, so taking it orally SWIY will absorb almost all of the drug. As for plugging, SWIM never said that plugging would work for every benzo but it will for xanax. Plugging allows a drug to be absorbed more effectively in the bloodstream at a pretty fast rate. SWIY says they have experience but SWIM doesn't know SWIY has experience because SWIY hasn't shown anything that can validate his credibility. BTW if SWIAnyone would like SWIM to cite a source of anything he said in this post for validation then SWIM would be more than gladly to do so he's just way to lazy to cite every single thing lol. In SWIM's opinion he is very experienced in xanax and restoril but thats as far as it goes for benzos. he's takin k-pins, valium, restoril, xanax, and ativan but other than the bars and temazies listed ahead its only been a single use. SWIM's town is very big into xanax and dope(meth). SWIM is scared shitless to ever try dope and xanax easily found its way to his DOC fast when a couple of his friends found a guy that knew a crooked pharmacist that SWIMyFriends were getting a 100 pack of em, so at first SWIM was just taking a bar or two, and when he would go above that he'd black out well finally SWIM got to where he could take as many bars as he wanted and would get more fucked up but wouldn't black out. So SWIM got to where he was taking 6 and a half bars at a time cause pretty much whenever SWIU needed them they could get them, except they used their connect in some moderation because when actual bottles,not prescription bottles that they give normal people but the bottle shaped like a square that come with 100 and says 2mg alprazolam and has that tin foil seal in the top of the bottle that they recieve from the company starts to "magically vanish" it raises eyebrows so after about 3 months of them having this connect it finally ended and SWIM's guess would be for the above reason. So SWIM went through the withdrawls of xanax which at the time he didn't realize how bad withdrawals from benzos actually were. he experienced terrible tremors, high anxiety, depression, paranoia, and agrophobia(afraid to leave his house). He said everything but the depression was gone in a week or so but the depression stuck for atleast a month. So yes SWIM has experience which experience is a good thing but knowledge about the topic is more important than experience although knowledge without any experience isn't good either because everyones body reacts differently than others so SWIY has to know their mind and body and to really find that is by having experience

jj_redick_stud4 added 12 Minutes and 10 Seconds later...

Also SWIM forgot to say that even with his experience with xanax he also cannot validate his claim even though SWIM is being completely how can SWIY prove that. When in a thread and the topic is asking for experiences or SWIY's opinion that's fine but when it comes down the scientific aspect of a subject SWIM's belief is that SWIY needs to be able to have scientific evidence to back it up by a reliable source

jj_redick_stud4 added 95 Minutes and 29 Seconds later...

Oh and oddly enough yesterday SWIM got his sleeping pill changed from 30mg of restoril to xanax 2 mg. Swim didn't even go in there trying to get prescribed xanax swim jus needed something different cause restoril 30 mg wasn't doing anything for him at all except relax him and if he took more than his prescribed dose then the days at the end of the month when he had none he'll go two different days without any sleep the previous night. So when she told him she was gonna give him xanax the maximum dose she could give swim. Swim prob shoulda said no but swim loves them so much it was like now swim can use them and not have to worry about the law but swims going to get addicted to them again but swim really cant help that he cant sleep and these help

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[claroscura]

contrary to popular belief, benzos are slightly water soluble. snorting is an option; their effects do hit you much faster this way (from what i've heard), but probably not all of the drug is getting used.

it's more effective to take them sublingually. some of it is immediately dissolved into the bloodstream via the vessels under the tongue, and the rest you wind up swallowing. a waste-free, nasty-tasting solution (depends on the brand, though; swim has tried teva 1mg and they're sort of sugary-tasting).

[phatassone]

snorting benzos is pointless, they have a far higher BA orrally...

[tyranny4u]

now that we know that most benzos won't be absorbed very good through
the membranes, let's think further: a xanax pill might weight 100 mg approxi-
mated. let it be 90 mg or 120, the tyrant has no scale as he doesn't sell
stuff.

so the substance is 1 % of the total weight.
you crush it and snort it and expect it to come in strong.

and now let's change the scene: the tyrant meets you in a club or at your
mates house.
he says to you: "hey, i've got some nice speed. it is ONE PERCENT! wanna
try a line? you only have to snort a 3 meters long street within a minute to
get some effects!"

got the idea?

[youandmeandrainbows]

Ok here goes...

SWIM's only experience with snorting benzos was quite a long time ago. Years ago SWIM found some 10mg diazepam and decided to snort them and then go see a movie with her friend. SWIM snorted 5 of the 10mg pills.

SWIM doesn't recall much burning after snorting them, but her experience didn't really differ much from taking diazepam orally.

Honestly, SWIM has never had much success with using diazepam recreationally. The few times she has taken it she either didn't take enough and felt nothing or she took too much and woke up not remembering much of anything. For her finding a happy medium never happened and she doesn't really find diazepam to be "fun" in any way (not being able to remeber feeling buzzed or having a good time kind of defeats the purpose to her).

Sooooooo, I don't know if this has been any more enlightening than any of these other posts but SWIM feels that snorting the diazepam was relatively the same as just taking it orally. BLACKOUT. So where's the fun in that?

SWIM prefers alprozolam or temazepam over diazepam, but has never snorted either. In her opionion snorting diazepam was truely unnesessary!!!!

Please be safe!
Snorting pills is NOT advisable!

[Venusia]

SWIM once snorted Xanax, and it was horrid. Yeah SWIM felt a little loopy and drunk for a short bit, but the burn was just not worth it. Worst. Burn. Evar. And this is coming form a person who chooses to snort pills regularly. SWIM is slowly getting off the toot toot train though. SWIM would hate to have an ENT look up their nose one day only have the their opioid contract shredded to bits.

Back on topic: SWIM does snort benzos, and just (like 10 minutes or so ago) took a 15 mg Temazepam up the nose to see if SWIM can finally catch a decent benzo buzz. It's a new scrip and it's in capsule form with very fine, fluffy powder inside. Little burn, no real taste, feeling sorta groggy...but not too groggy to communicate via speech nor the written word thus far. SWIM's brain may just not play well with benzos, even via oral administration. Maybe SWIMs brain is an opiate snob. *shrug* Maybe they'll synergize nicely with SWIMs 60 mg MSContin (taken via mouth only, as SWIM hates waxy globs in SWIMs throat).

venusia added 27 Minutes and 54 Seconds later...

Originally Posted by XanderCrews

SWIM likes snorting clonazepams, especially the green, disolvable ones. Minty fresh!

SWIM also enjoys the minty goodness of a clonazepam. It's a breath mint AND a medication in one. One thing SWIM has found is that the Mylan clonazepams do not have that minty fresh drip, just the nasty ol' pharmie drip and burn. Yuck. Caraco brand, so far in SWIM's experience, is the minty one.

Reputation Comments on this post:

lots of double posting and swearing but every post of this user appears to be directly ontopic and concisely full of fac...

[baron samedi]

SWIM has never tried snorting benzos before. He's tried Diazepam and Lorazepam by swallowing whole, plus one experience of chewing some Temazepam.
Going off track slightly, is chewing or swallowing benzos more effective? And is sublingual admin more effective than oral anyway?

[claroscura]

advantages of sublingual administration do mean that, yes, the drug is not subject to first-pass metabolism. (however, not that much of the drug is even lost in first-pass metabolism in the case of benzodiazepines.) in some sense, then, it is more effective this way. however, benzos are not fully miscible in water - which means that not all of the drug can be administered this way. swim theorizes (NOTE: "theorizes") that this may be the most effective mode of administration, assuming that whatever is not absorbed directly through the mucous membrane is later swallowed. swim also theorizes that there is a higher probability of increased mucousal absorption in this route than through insufflation, because of the increased moisture in the mouth relative to the nasal passages.

chewing before swallowing generally means that absorption will take place faster/sooner. obviously whatever stays stuck to one's teeth would be a waste.

parachuting is the slang for another oral method of administration, in which the user crushes the pill before placing it in something like a piece of tissue. this speeds up absorption and minimizes loss.

[flashcash]

swim knows benzos have lower bioavailability in the mucus membranes and are not completely water soluble. that's why swim always does 0.5 oral (chewed) and 0.5 snorted.
0.5 is the maximum dose swim can snort, if he snorts 1mg he feels it exactly the same like 0.5 and its indeed a waste. but eating 0.5 and snorting the other 0.5 he feels the incredibly fast and intense kick from the insufflated part and the eaten part keeps him high after that initial kick. ( when snorted xanax last shorter for swim )

flashcash added 10 Minutes and 23 Seconds later...

Oh and BTW, Alprazolam, Bromazepam and Diazepam are the snortable benzos in swim's experience; when crushed they go into a soft, light powder that can easily be absorbed in the sinuses or under the tongue.
Swim has also snorted Clonazepam and Lorazepam but it depends on the brand, some brands of these come in a hard form and are difficult to crush and the powder is hard even after being proper crushed, but again, it depends on the brand, swim has had clonazepam and lorazepam that were very soluble as well.

[Piglet]

If your dealing with a drug that is virtually insoluable in water then snorting really is not a good idea. I suppose that a FEW benzodiazipines form water soluable salts so thats a maybe. I think it's important to point out that sudden intake of benzos can be vey dangerous. The BNF specifically says with 'Diazemuls', an injectable diazepam suspension, that resuscitation equipement should be on hand when using this medication!

For those of you with a death wish, why not simply order Hemineverin (clomethiazole) off the internet? It's as potent & as dangerous as barbiturates and it feels like you took a lot of alcohol. Of course, it killed Keith Moon...

[missparkles]

Gotta disagree, chlormethiazole is nowhere near as dangerous as barbiturates, of course that depends on dose.
But the usual barbs, Tuinal, Nembutal and Seconal, are definitely more dangerous than chlormethiazole.
Chlormethiazole doesn't knock you out cold, as barbs do. The effect is more sedating, it's actually been used for insomnia. In the BNF it's listed as a sleeping tablet. The first 2-3 doses of chlormethiazole will give you a burning sensation near the sinuses in your nose, they do that to 90% of everyone that takes it, don't know why.
It's nothing like alcohol, although people believe it mimics the effects of alcohol, as it was used (mainly in the 70-80s) as an alcohol W/D meds.
W/D from barbs and chlormethiazole are different too.
Barbs produce seizures, chlormethiazole, while it can cause seizures, usually produces psychosis, if withdrawn abruptly. Seizures are rare.
Reason?
Barb fits (seizures) come on extremely quickly, and are seen. Psychosis is the first symptom to manifest after Heminevrin is stopped abruptly, usually the odd behaviour that accompanies this is noticed and a replacement schedule is put in place.
Result? No fits.
The psychosis that accompanies overdose (not a large overdose, not enough to kill) cannot be reversed by Heminevrin. Although chlormethiazole it is given on a reducing schedule to anyone exhibiting symptoms of psychosis from this medication, the psychotic episode doesn't disappear when the drug is re-introduced, as usually happens with many other drugs. You just have to wait.
And yes, Keith Moon did die from a Heminevrin O/D, but he'd taken a load of other drugs, and booze.
Sparkles.