Chamomile's GABA receptor affinity

[Ontherooftops]

SWIM has read that chamomile binds to GABA receptors at some level. It seems this aspect of chamomile is not very thoroughly researched. Do any SWIYs out there think that possibly there could be a way to identify what part of the chamomile flower has this affinity and to isolate it, possibly creating some kind of a weak GABA-ergic anxiolitic? Or possibly this substance, when isolated, could act as a precursor to a stronger anxiolitic?

SWIM has noticed in the past that chamomile potentiates benzodiazapines for him slightly, but its possible this is psychosomatic.

Should swim maybe perform some kind of testing with extract of chamomile? It seems to him that further research is necessary, any SWIYs know anything to the contrary?

[tayo]

it's possible, search for "compounds found in chamomile" on the internet and then go from there and search what each one does. if it has any affinity for GABA receptors it is probably weak, and if true and isolated some chemist out there might be able to attach a few fragments of molecules to make it have a higher affinity for GABA. if swiy thinks it potentiating benzos then its also possible that it is inhibiting a liver enzyme involved in elimination of benzos. utfse for more info on that. interesting idea though.

[Alfa]

Drinking large amounts of chamomille tea makes you feel quite sedated.

[Orchid_Suspiria]

Ah this is pretty interesting,swim discovered recently that chamomille is very synergistic with alprazolam.

[tayo]

based on o.s.'s discovery that would imply that it isnt doing anything with liver enzymes but has an affinity for the receptor itself, since alprazolam and GFJ has no effects on bioavailability because alprazolam's is so high already. so if greater effects from chamomile and xanax its like adding more of something similar.

[tayo]

Here's what's in it...


Alpha-bisabolol, Choline, Eo, Galacturonic-acid, Glucose, 2,4-dihydroxybenzoic -acid, 2,5-dihydroxybenzoic-acid, 3,4-dihydroxycinnamic-acid, 3-carene, 3- hydroxy -2-methylidene-butyric-acid-angelate, 4-hydroxy-3-methoxy-be nzoic-acid, 4-methoxybenzoic-acid, 6-3-dimethoxyquercetin, 6,7-dimethoxyquercetin, 6-hydroxy-luteolin-7-glucoside, 6-methoxykaempferol, Alpha-bisabololoxide-a, Alpha-bisabololoxide-b, Alpha-bisabololoxide-c, Alpha-bisaboloneoxide-a, Alpha- muurolene, Ap igenin Glucosides, Ascorbic-acid, Axillarin, Azulene, Betacaryo-phyllene, Beta-damascenone, Bisabolene, Borneol, Bornyl-acetate, Caffeic-acid, Calamene, Capric-acid, Caprylic-acid, Caryophyllenepoxide, Catechin-tannins, Chamazulene, Chamomilla-esters, Chamomillol, Chlorogenic-acid, Chrysoeriol, Chrysoeriol-7-glucoside, Chrysosplenol, Chrysosplentin, Cis-caryophyllene, Cis-en-yn-dicycloether, Epsilon-1-(2,6-dimethylphenyl) -2-buten-1-one, Ethyl- benzoate, Ethyl-decanoate, Ethyl-palmitate, Ethyl-phenyl acetate, Eupaletin, Farnesene, Farnesol, Furfural, Galactose, Gallic-acid-tannin, Gentisic-acid, Geraniol, Herniarin, Hyperoside, Isoferulic-acid, Isorhamnetin, Isorhamnetin -7-glucoside, Jaceidin, Kaempferol, Linoleic-acid, Luteolin, Luteolin glucosides , Matricarin, Matricin, Niacin, O-coumaric-acid, P-coumaric-acid, Palmitic-acid, Patuletin, Pectic-acid, Perillyl-alcohol, Polyacetylene, Quercetagetin-3,5, 6,7, 3',4'-hexamethylether, Quercetagetin-3,6,7,3',4'-pentamethylether, Querce-tagetin, tetrameth ylether, Quercetin, Quercetin-3-galactoside, Quercetin -7-glucoside, Quercetrin, Quercimeritrin, Rhamnose, Rutin, Salicylic-acid, Sinapic-acid, Spathulenol, Spinacetin, Tannin, Thiamin, Thujone, Trans-alpha- farnesene, Trans-en-yn-dicycloether, Triaconta ne, Umbelliferone, Xanthoxylin, Xylose


if any of those things are structurally related to benzos or even thujone, swim would guess that is a likely candidate for our culprit.

someone should look in to 3- hydroxy -2-methylidene-butyric-acid-angelate

[Orchid_Suspiria]

Swim was very surprised to learn this himself,he discovered it quite by accident really.Now he has facts to back up experience

[Ontherooftops]

Some sources to back up the theory...

http://ci.nii.ac.jp/naid/10016663096/en/

http://www.uspharmacist.com/oldforma...article_id=100

There are way more but they all say the same thing more or less. Suggesting that apigenin could be responsible for this action... but the molecule isn't too close to any benzo.
Also... swim just noticed that thujone is in that list of constituents.

There's lots and lots to look through there, its no wonder scientists haven't figured out the exact compound.