Combinations - GHB and stimulants info needed - Reward offered

[MrG]

Ok I am reading through that article (props to Tryp) but, whilst it discusses *probable* interaction regarding 5-HT, NE and DA it doesn't really cover the physiological issues relating to BP or HR other than to mention the increase created by MDMA. Let me get back to you on that.

[Pino]

Swim isn't in for the big price here. He just has some anecdotecal information to share. Swim has developed a tic to measure his blood pressure (and heart rate) when using drugs. He noticed GBL + stimulant results in a lower blood pressure and lower heart rate than stimulant without GBL. The difference is roughly 10 points. So when he used to have a bp of 150/90 with the stimulant, he would have with the gbl added in the mix 140/80. It seems to affect the diastolic pressure more than the systolic pressure.

Swim is used to the blood pressure measurement thing of his, so his blood pressure won't go up anymore, when he is performing a measurement. He adjusted the amount of stimulant taken at once a while ago, when he started this habit to keep his blood pressure in safe limits.

This is hardly science, so if you have different experiences please share it.

[westmeetseast]

Mr. Not-me find that when takes GHB (with doses varying from 1.5 to 3 grams) within 4 hours of taking his prescribed 10mg Ritalin, the euphoria-inducing powers of the GHB is greatly decreased. He has observed approximately the same results on over 10 different occasions. Now he always waits at least 4.5 hours after his last daily dose of R before taking G.

Strangely enough, the Ritalin gives him a great buzz when he takes it with alcohol or xanax!

[Pino]

Swim'snt a pharmacist, but could someone point out what the effect of the GHB on the stimulant is. What are the dangers? I would like to understand the article is saying.

Swim never found a problem with mild stimulants. GBL dropped it here. With harder stimulants, he never tried.

[Benga]

a very good post on the subject here in this "mephedrone" thread :

http://www.drugs-forum.com/forum/sho...hp?p=693830#74

[Synesthesiac]

On a purely personal anecdotal level; GHB and GBL are wonderful to combine with stimulants. They are not too far off having a few beers (or other similar CNS depressants) with your stimulant of choice, and tend to give a more calming effect to the experience. Swim has never noticed a bad reaction between GBL/GHB and any of the stimulants he has mixed it with (Cocaine, Mephedrone, Methylone, MDPV, etc) and it was a very worthwhile combination in swims opinion. Takes the "jitters" away from many stimulants and helps avoid overstimulation.

However the one thing swim has noticed is that (if you use very large amounts of both GHB and the stimulant) when the GBL/GHB wears off and the stimulant has also worn off, the combination of a dopamine rebound from the GHB and the residual stimulantion (stimulant anxiety) can be a very rough mental journey. And not one that many would want to repeat I would wager.

EDIT: One time Swim had been awake for two days and had been continually redosing with MDPV and GBL in very irresponsible amounts. In total about 100mg of MDPV was consumed along with about 30ml of GBL. The comedown off the MDPV combined with the dopamine rebound from the GBL was absolute hell; easily Swims worst drug experience. His resting BPM went right down to 50-60, and he felt very lightheaded and kept getting continual mini 'blackout' type flutters as his heart palpitated and skipped beats. His muscles were also very tense the whole time, this seemed most prominent around his heart area and especially effected his left shoulder muscles. This lasted about six hours then he started to feel better very slowly, but could not sleep for a further three days! So ended up awake for five days in total. Two days of euphoria, followed by three of absolute hell. Definately not worth it.

Synesthesiac added 264 Minutes and 34 Seconds later...

So to have a bash at actually answering the OP I dont think that the combination of GHB with stimulants is dangerous as such, but since the GHB cancels some of the stimulation people will tend to do a lot more of the stimulant in question than they would without it. So the combination in itself is not dangerous, its what people decide to do when combining that matters.

Reputation Comments on this post:

Interesting experience

[Shuras_Lab_assistant]

As I stated here: http://www.drugs-forum.com/forum/sho...7&postcount=38 SWIM loved taking amphetamine together with g. From memory SWIM can tell that, combining these, no negative effects on SWIM's body were noticed but it promoted sweating, especially if he took high doses of g - Sometimes the sweat was dripping from his face, SWIM told me.

[10outof10]

Hello,

Having a read over Mr G's post a thematic paper by the EMCDDA, (was going to post it up myself but then found it!!) there's quite a few interesting thoughts..here's the link

http://www.drugs-forum.com/forum/loc...28&linkid=5036

From combined studies from all over Europe, EMCDAA state "Pharmacologically, GHB is believed ultimately to increase the levels of dopamine in the brain with relatively little effect on other neurotransmitter systems. GHB appears to induce some bradycardia (heart rate below 60 BPM) but no effect on blood pressure. An increase in prolactin and growth hormone secretion has also been observed in humans. "

They also mention a rather interesting sounding study..
I quote "An unpublished UK study — using data from the General Register, the Birmingham Regional Laboratory for Toxicology and the National Programme on Substance Abuse Deaths at St George's, University of London — recorded a total of 44 GHB/GBL-related death cases in the period 1995 to 2006. The number of cases appears to have first peaked in 2001–2 and then risen to higher levels in 2005–6. Of the total 44 cases, 4 involved GBL, mostly in 2005–6, including one case where GBL was the only substance used. The majority of cases involved the ingestion of at least two other substances, typically alcohol and/or stimulants. It should be noted there is considerable variability in the range of GHB/GBL levels at post mortem. Several cases with low levels are being closely examined to determine if the GHB detected is endogenous in origin. Where the circumstances were known, the majority of deaths (22 of 38) followed recreational use, often by individuals with a history of substance use."

SWIM has some contacts where SWIM may be able to get this study, SWIM will certainly post if SWIM does..

Some other interesting parts..

" In the UK, one London hospital emergency department — with a catchment area that includes local club venues which typically, but not exclusively cater for the gay club scene — recorded a total of 158 GHB and GBL presentations in 2006. The vast majority of cases related to self-reported recreational use of GHB, with five cases of accidental misadventure or deliberate self-poisoning. 34% of patients reported that they had ingested GHB or GBL alone, but there were no reports of 1,4-BD ingestion. 34% of patients reported combinations with alcohol, 32% with MDMA, 22% with ketamine, 14% with cocaine and 14% with amphetamines. It should be noted that whilst most self- reports referred to consumption of GHB, chemical analysis of samples collected from night clubs in the same catchment area during the same time period found that over half of the samples contained GBL rather than GHB. Most of the individuals presenting to the emergency department were males aged 20 to 34 years. (Wood et al., 2008). Reports from an Edinburgh hospital show that GHB- related admissions have increased from only 3 in 2000 to 39 in 2006."

Now I'm no chemist or Doctor and like laymans terms but mixing stimulants and depressants isn't uncommon..take buckfast and vodka redbull for example. Whilst they might not be the best mixes, many live to tell the tale )

[BoyInTheCountry]

SWIM knows he is not going to be adding anything to the thread but he would feel silly starting a new thread as he was going to before seeing this as his question has to do with using GBL with a stimulant, maybe someone can just answer quickly while posting there message.

SWIM used to use GBL and Mephedrone quite a lot but rarely together, SWIM used to use the GBL as he loved how easy it was to get to sleep but normally the Mephedrone had worn off anyway. SWIM used no drugs for 4 months but has taken MDPV recently and find the 12 hour after all effects have worn off insomnia horrible as well as the nasty nasty come downs. Would GBL be effective in helping him get to sleep or would it only cause more adverse effects? 3ml used to be enough to help SWIM sleep like a baby. He would try himself but has no GBL at the current.

Thanks.

[10outof10]

Someone's already started a post here..

http://www.drugs-forum.com/forum/sho...light=MDPV+GBL

Not knowing enough of MDPV, I can't help responsibly, maybe try asking there..