Inhibition of Cytochrome P450 2D6 Metabolism of Hydrocodone to Hydromorphone Does Not Importantly Affect Abuse Liability (Kaplan et al, 1996)

[Jatelka]

A new entry has been added to Drugs Archive

Description: Originally published in JPET

More on the role of the cytochrome system in the metabolism of Hydrocodone

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[Bajeda]

Comment:

Was going to up this but looks like you already got it. Concise well-written paper that clearly elucidates the hydrocodone O-demethylation process and the role of hydromorphone in producing overall effects; raises some good questions.

To check this out, and rate it or add your own comments, visit Inhibition of Cytochrome P450 2D6 Metabolism of Hydrocodone to Hydromorphone Does Not Importantly Affect Abuse Liability (Kaplan et al, 1996).
The comments you make there will appear in the posts below.