90% muscimol powder vs actual amanita muscaria mushrooms

[Alfa]

I noticed 90% muscimol powder is available from a source. Has anyone tried this?

[jux]

haven't tried it personally, but here is information supplied straight from the vendor on another forum:


"hello all
as the purveyor of this extract I will explain its price,
the process of extraction ,isolation and purification of above said compounds is a long and extensive process using expensive solvents,
the reason for purification is to relieve a person from the effects/dangers of the other compound in the muscaria fungi wich is muscarine
muscarine is what causes the sickness, limbs going numb and other assorted physical uncomfortable feelings that occur when using the whole fresh or dried fungi.

...

large mammal experiments have shown the 5mg ibotenic acid/muscimol to be sufficient for GABA activation when vaporized"

i will supply a link to the thread if you like (i wasn't sure if links to other forums are allowed)

[Synchronium]

Originally Posted by jux

hello all
as the purveyor of this extract I will explain its price,
the process of extraction ,isolation and purification of above said compounds is a long and extensive process using expensive solvents,
the reason for purification is to relieve a person from the effects/dangers of the other compound in the muscaria fungi wich is muscarine
muscarine is what causes the sickness, limbs going numb and other assorted physical uncomfortable feelings that occur when using the whole fresh or dried fungi.

Seems said vendor mentions nothing about ibotenic acid. This is used in medical research to cause brain lesions. I'd be more worried about this than muscarine.

[Alfa]

Does anyone know what the dose of muscimol freebase is if AFOAF would smoke this? The above indicates 5mg for a mixture of ibotenic acid with muscimol. But what about muscimol freebase alone?

[Daniel Lioneye]

SWIM was also wondering about this,

Here is what SWIM found from his source

Derived from Amanita Pantherina mushrooms. Containing 90%+ muscimol and 5-10% Ibotenic acid. This material has serious research and clinical potential as it is a gaba receptor agonist and very unique in its actions. As this is refined to an absolutely impressive purity the negative alkaloids have been removed thus leaving only the alkaloids of interest.

It seems quite expensive.

[Swimster]

FROM WIKI:
The psychoactive dose of muscimol is 15-20mg [although this dosent specify route of administration]

LD50 mice: 3.8 mg/kg s.c, 2.5 mg/kg i.p.
LD50 rats: 4.5 mg/kg i.v, 45 mg/kg orally.

[snapper]

SWIM guesses that it will be a similar experience to baking normal amanitas to convert all the goodies. SWIM has found amanita unpleasant during SWIM's trials and dropped it. SWIM would love to hear about a trial with the pure alkaloid (were there to be some rich SWIM out there willing to part with the money to try it...). SWIM also wonders if there are any safety issues with this. SWIM's third trial was an OD and it was somewhat scary and very unpleasant. Perhaps this is due to other components of the mushroom, though..

[Swimster]

Originally Posted by snapper

SWIM guesses that it will be a similar experience to baking normal amanitas to convert all the goodies. SWIM has found amanita unpleasant during SWIM's trials and dropped it. SWIM would love to hear about a trial with the pure alkaloid (were there to be some rich SWIM out there willing to part with the money to try it...). SWIM also wonders if there are any safety issues with this. SWIM's third trial was an OD and it was somewhat scary and very unpleasant. Perhaps this is due to other components of the mushroom, though..

amanitas are said to cause delerium. perhaps this was the bad counterpart of the trip.

[snapper]

Not so much delerium as diarrhea, dizziness and nausea along with a sense of anxiety / panic waxing and waning thoughout the experience. No strong psychedelic or deleriant effects, but maybe the side effects distracted from that.

Reputation Comments on this post:

LOL-thanks for the aminitas experience input, swim will never experiment with it.

[Swimster]

what the hell? why do swiys bother? Thanks though snapper,
because swim loves to learn from other peoples experiences
bad or good.LOL. And Swim just learned one right now.

[jux]

yeah regular aminitas dont sound like to much fun, but i think that is the whole point of the isolate...no muscarine (which supposedly is responsible for giving lab rats the nasty body load)

[psyche]

This has crossed SWIMs mind too, smoking the actives of amanita. Would it be feasible to extract the muscimol & others after drying the mushrooms to eliminate most ibotenic acid? Would a simple water extraction yield smokable material? SWIM could give it a try, as it feels safer, cleaner and easier way to consume those unpredictable little fuckers. Smoking peels of the hat has produced some very mild, near placebo effects.

[genaro]

too bad, swim had 25mg 99.99% pure muscimol (from lab chemicals supplier) a while ago, which he finally didn't bothered trying, and as he couldn't think of anyone willing to try such an unusual stuff he just throwed it away...

[fluoroantimonic]

Would a simple water extraction yield smokable material?

Don't smoke it! If you really want do a water extraction then do it and drink the water, that should give a good effect.

[Bajeda]

Has anyone tried vaporization as a mode of ingestion, as opposed to outright smoking?

[Niasyn]

Originally Posted by Bajeda

Has anyone tried vaporization as a mode of ingestion, as opposed to outright smoking?

SWIM recently ordered 3 grams of a powdered 15x extract, I'll write up a report after he gets to sample it in his vapor genie, though he has no previous amanita experience to judge the effects by.

[Routemaster Flash]

Originally Posted by Bajeda

Has anyone tried vaporization as a mode of ingestion, as opposed to outright smoking?

SWIM tried heating some dried cap in a glass pipe with indirect heat - something close to vaporization, he supposes - and got nothing that could be clearly distinguished from placebo. Tried directly smoking them too, to no great effect. Hardly surprising, as SWIM ate 6+ caps from the same batch and got little/nothing.

Apparently there are reports of people getting a "mild, cannabis-like intoxication" from smoking the caps, with cannabis. Well no. Shit.

[CoryInJapan]

Originally Posted by Routemaster Flash

Apparently there are reports of people getting a "mild, cannabis-like intoxication" from smoking the caps, with cannabis. Well no. Shit.

I hate to go off tpoic but in my opinion its worth pointing out to ROute that

Cannabis isnt an Intoxicant.

its pretty non-toxic

Swim Smoked/Ate/Drank a batch and had little affect.

CoryInJapan added 0 Minutes and 24 Seconds later...

batch of amanita's

Reputation Comments on this post:

linguistic fallicy, word roots don't directly trasfer their definitions

[Routemaster Flash]

Originally Posted by CoryInJapan

I hate to go off tpoic but in my opinion its worth pointing out to ROute that

Cannabis isnt an Intoxicant.

its pretty non-toxic

Swim Smoked/Ate/Drank a batch and had little affect.

CoryInJapan added 0 Minutes and 24 Seconds later...

batch of amanita's

And I should point out to you that "intoxicated" does not mean "suffering the effects of a toxin". http://en.wiktionary.org/wiki/intoxicate

[Niasyn]

Well my friend tried vaporizing his 15x extract and got no effect, also capped two 1.6 g doses and ingested on separate occasions and received only slight nausea and a sweaty brow for 5 minutes so perhaps his batch was simply not extracted properly.

[chaosx]

evil got a 15x extract, one gram. he tried smoking it and it would not really burn. eating it produced no effects. evil is not sure how it was supposed to be used, how it was made, or if 1 gram is even enough.

[Routemaster Flash]

Originally Posted by chaosx

evil got a 15x extract, one gram. he tried smoking it and it would not really burn. eating it produced no effects. evil is not sure how it was supposed to be used, how it was made, or if 1 gram is even enough.

Well SWIM's eaten over 15 grams of dried cap before and got no appreciable effect, so it's certainly plausible that 1g of 15x extract is below threshold.

[Alfa]

Please keepthis thread on topic: what are the effects of pure muscimol and how do they compare to amanita muscaria mushrooms.
Please discus amanita 15x extracts in a thread dedicated to that. If there is none then please create one.