Valium detoxification (& grapefruit juice potentiation)

[~lostgurl~]

A new entry has been added to Drugs Archive

Valium detoxification (& grapefruit juice potentiation)
20 seconds

valdetoxt.jpg

The molecule shown here is CYP3A4 (the cytochrome p450 that plays the major role in drug detoxification in your body. It has been estimated that this enzyme acts on about half of known drugs. For instance, it modifies the antibiotic erythromycin, shown at the bottom in blue. It also detoxifies such diverse drugs as codeine, diazepam (Valium), paclitaxel (Taxol), and several anti-HIV drugs.

Prescriptions and p450 Doctors must be careful to keep the cytochrome p450 enzymes in mind when they prescribe medications. For instance, you may have seen warnings on prescriptions, telling you not to drink grapefruit juice when taking a medication. Grapefruits contain a flavinol molecule that inhibits cytochrome p450 enzymes. This will slow down the detoxification of drugs, which may cause them to have stronger effects than expected by the doctor.

The clip is just a preview and doesn't show anything too interesting, the statement above says it all really.

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Valium detoxification (& grapefruit juice potentiation)
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