Drug info - The Analgesic in Leech Oil, (the secretions of medicinal leeches)

[tayo]

definitely good points and understandable that this is not for everyone to research, and tayo's robot is going to try smoking an alcohol based extract. and see what the robot can't remove from before moving on to different species, dried, anticoagulated blood that has been cleansed with alcohol could make for a smokeable dose, and it's not like the robot is going to share its robot blood with other robots, nor let it sit around for more than 2 days time, all the while refrigerated. and nagognog is gonna sue the partnership for a drug free america and bring in peta, since this might catch on? we'll see. they truly is alot of potential here still, whether swim reaches goals depends on availability to some lab time, so time will tell. and the centrifuge is a good idea if not only for the fact that it would not be red anymore.

yes indeed mad scientist here.

[snapper]

SWIM thinks the centrifuge would be an excellent cleaning step. If none is available, leaving the bloody fluid in a tapered test tube or funnel will allow the solids to settle to the bottom, and the liquid fraction can gently be removed with a pipette. This first step would best be done with some saline solution so that the blood cells do not rupture, otherwise the hemoglobin will stay in solution and make it stay pink.

[Krisco]

How can we stop the DEA from reading this and treating them like restricted chemicals only available to hospitals?

Reputation Comments on this post:

I know!!!

[tayo]

Originally Posted by Krisco

How can we stop the DEA from reading this and treating them like restricted chemicals only available to hospitals?

I don't know. it will take them a while even if they want to.

About the blood... the robot's are going to move leeches to one container that has significantly less water and no blood, leave them for a couple days, see if the leeches leave anything behind, hoping that they have the compound in their saliva at all times rather than just when attached. then transfer them back into water and extract whatever robot can from drying the container that had less water and now hopefully saliva in it too. that would be an ideal harvest rather than anything with blood in it. then let it sit in some alcohol and evaporate.

[tayo]

Alright! ... so the robot harvested saliva, mixed with alcohol, evaporated and was left with probably 0.1 grams of goop. Goop was then scraped together and rolled in a small bowl of damiana and smoked. The bowl took a long time to smoke and sizzled, probably half of the smoke was vapors. Robot is now very relaxed and vision has changed slightly with a general feeling of well-being, robot's a little slowed down and robot says there is definitely something going on here, but it will likely take alot to achieve desired effect.
Now robot will be brainstorming for ways to increase salivation of leeches and will possibly put goop in capsules and ingest for second experiment. It would make sense that the leech would provide more of a rush when attached because it is going right into the blood stream, and it is likely producing much more saliva than when trekking around in a container. There is work to be done!

hopefully "goop" adds to the cringe effect this thread already has.

Reputation Comments on this post:

good work. you've got dedication. don't stop now, we're counting on ya!

[rxbandit]

Damiana might not be the best choice if you are trying to isolate or notice an effect. Damiana on its own when smoked promotes relaxation and a strange euporia that could easily cloud any real evidence of an effect. Damiana also has the nasty habit of inducing obnoxious smiling which could also make this practice look more fun then it actually is. My suggestion would be for swiy to use a non pyschoactive medium for smoking to isolate the effect of the leach oil alone. otherwise swiy runs the risk of reporting the effect of the damiana or the placebo rather then the actual compounds swiy is trying to investigate.

[grandbaby]

Reading this thread for the first time, I was all, "Oh, that Tayo, he's such a nutter! Lah dee dum..."

Given, however, that it appears there's at least one other person following in your bloody, goopy footprints, the thread has turned quickly from "amusingly disturbing" to plain "disturbing." I guess the drug-propaganda people are right after all. If someone's buddies are sticking leeches on themselves, then that someone is going to do it too...

... and then on the other hand one has to kind of admire the intrepidness (albeit somewhat half-cocked intrepidness) of the Original Leecher. While at the same time blinking repeatedly and saying, "I didn't just read that, really, did I?" ...

Reputation Comments on this post:

haha so true

[tayo]

Yeah, damiana has never provided noticeable effects for the robot, but I do understand that this is possible. It was probably 50% leech goop and 50% damiana, very little but any suggestions for a medium?... even tobacco would not be a good idea because of the nicotine, and damiana just happened to be around.

Reputation Comments on this post:

Very informative and leeches are one subject that you wont see many topics about on df.

[Swing]

Just curious, but has swim thought about what the organism does with its waste (assuming some kind of urinary and/or fecal matter) when it's in the container... I'm just hoping robot isn't rolling up globs of gooey excrement to injest in robot's body.

Reputation Comments on this post:

good point

[neuroplastic]

Intriguing robotic research, SWIM would bet something useful would come out of this research if the proper techniques are used. As far as invertebrates producing morphine-like substances, how about them just straight up producing morphine, as does Ascaris suum:

http://opioids.com/abstract/wormmorph.html

Other interesting species:

Epibpedobates tricolor (Amazonian frog, warning TOXIC)
Phyllomedusa sauvagii and P. bicolor (Waxy Monkey Tree frogs, TOXIC)

SWIM would really like to keep a coupla Waxy M.T.F.'s on hand based on reports :

http://www.erowid.org/archive/sonora...ad/bicolor.htm

Props to the dedicated robots devoting their time to science .

Reputation Comments on this post:

good link! the research continues!

[neuroplastic]

Oh yeah, one more thing. SWIM suggests not using a substrate to smoke "goop", in order to isolate any psychoactive properties. Generally, the freebase of compounds can be made by subjecting them to a basic solution (baking soda and water, etc.). Freebases are (SWIM believes) generally less likely to degrade before vaporization as temps. rise. So, SWIM suggests the robot could add baking soda to "goop solution" until pH is good and basic, and then evaporate solution to form residue. The robot might then go ahead and vaporize this residue, using methods commonly known. No need for substrates. Opium pipes are probably the oldest freebase pipes...the base of pipe is heated but substance is not subjected to direct flame. Good luck...

-SWIM

[tayo]

Originally Posted by neuroplastic

http://www.erowid.org/archive/sonora...ad/bicolor.htm

Props to the dedicated robots devoting their time to science .

Okay however cool this may be...
"
applied to self inflicted skin burns to produce an agonizing attack of diarrhea, vomiting, tachycardia and systemic collapse, that is followed by a state of hyper-acuity of the senses attended by abundant energy and stamina without need for food or drink. Among other components, it contains dermorphin and deltorphin, peptides with analgesic properties 2000 times more potent than morphine at the cerebral level.
"
I don't think anyone wants those side effects, if someone could isolate... that would be cool. How would one collect from the worm?

[neuroplastic]

Hey,

Oh come on, does simultaneous involuntary defecation, vomiting, loss of motor control etc. sound all that bad . Obviously, pretty much the worst side effects SWIM has ever heard of from any compound intentionally taken to not commit suicide or anything like that. Certainly a poisonous compound to be avoided. Isolation of Waxy frog dermorphin from Phyllomedusa sauvaei (and a few other species) dermal secretions is key. Check out dermorphin.

As for the worm, A. Suum, SWIM would think it simple (though illegal and possibly not worth the effort) to grow them in an easily filterable media and simply do a water wash of the whole lot (assuming hundreds/thousands of worms) every so often. A fictional robot might try culturing them, procuring their viable eggs through a source such as this:

http://www.excelsior-sentinel.com/ascaris.html

SWIM is too preoccupied at the moment to personally research subject but is interested and willing to give advice . Keep on truckin', soldier...

[Metalcore322]

This is really damn interesting....
Swim has to hear how it ends!

[snapper]

Hey Tayo, that reference is verbatim about a treefrog (not a worm) Phyllomedusa bicolor, or the giant waxy tree frog of SA. They burn themselves and rub the secretions of the frog into their skin, then cunvulse with bloody diarrhea for a few days, and if they survive it can hunt for 2 weeks with night vision, superhuman strength and no sleep or food. The active ingredients are peptides (ie-small proteins) which are not as stable or extracted in the same way as small organic molecules. SWIM does not know that this would apply to leaches. Dart frogs (epibates, dendrobates, etc) need to eat certain insects to be toxic. however the Phyllomedusa produce these toxins with only endogenous precursors. Frogs are indeed an excellent source for novel psychoactives, but aside from Bufo alvarius, they are mostly peptides (which, BTW, could easily be made in a properly equipped molecular biology lab).

[hoodabudda]

steve-o put a leech on his eyeball in jackass 2. omg that must have sucked.

[entheo]

Originally Posted by hoodabudda

steve-o put a leech on his eyeball in jackass 2. omg that must have sucked.

As long as the leech didn't swallow!