Codeine's Synergy with Tramadol.

[Ethyl]

Swie is using opiates again in a daily basis for 3 weeks, and he's got now quite a small tolerance. I've seen him using mainly codeine and tramadol, and during that time he wanted to be on the nod at least everynight after a days work..
He was taking (cause he stopped/winned himself since yesterday) doses of 300/350mg tramadol with very little euphoria, but he didn't want to take doses of more than 400mg, so he started mixing the codeine. Here is what he found best:

He would take the dose of tramadol, then he would wait for the peak (around 2.5 to 3 hours later) and then he would boost his nod with a small dose of codeine.

This will add sedation to the tramadol nod and add other types of opiate effects that are not present in tramadol. It makes tramadol feels more of an opiate.

Swie is very happy with this combo.

[MrJim]

Would it really be called potentiation, though? Using two different opiates isn't really the same as tweaking one with a non-opiate.

[Paracelsus]

Errm, tramadol and codeine are both inactive by themselves. Both get active when metabolized through CYP2D6. If taken together, the result will probably be weaker than the expected sum. That's hardly potentiation.

Swiethyl might look into grapefruit juice potentiation for tramadol (it's in the tram forum). It works pretty good, SWIP tells me.

[Ethyl]

Tramadol does not seem to interfere much in codeine metabolism.
Codeine seems to interfere too much, that's why i said after the peak (that corresponds to peak values).

[Ethyl]

Originally Posted by MrJim

Would it really be called potentiation, though? Using two different opiates isn't really the same as tweaking one with a non-opiate.

That's a valid point of view.. But it increases the narcotic high of tramadol with other sensations.

[Paracelsus]

Originally Posted by Ethyl

Tramadol does not seem to interfere much in codeine metabolism.

Well, I've never tried a combination of tramadol and codeine, so I can only speak in theory. In theory, both substances are made active by CYP2D6. That means they are competitive on CYP2D6. That would mean less effects than the sum.

But your point about taking the codeine after the peak seems relevant, because at that time, most tramadol will have already been metabolized to O-desmethyltramadol. Who knows. Looks like a promising combination. Not potentiation, but a good synergy.

[delphinen]

SWIM have been taking Codeine and Tramadol since almost half a year ago. Dont mix them. Take more Tramadol or more Codeine, but dont mix them, its dangerous.

[Paracelsus]

What exact dangers are you talking about? Is it respiratory depression or something else? Please share SWID's experiences and knowledge on the topic.

[delphinen]

only time SWIM had a seizure was when he took 500mg Tramadol and 120mg Codeine in less than 2 hours.
Now SWIM is taking up to 700mg of Tramadol (heavy doses) but rationated through 6 hours and he never had any problem.
SWIM thinks that the Tramadol metabolite its safe to enjoy, problem is when Tramadol overflows the body and its not yet metabolized.
SWIM recommends taking Codeine after/during the trip has already peaked, but not ANY minute before.

[GrailKing]

Max tram dose per 24/7 is 400mg. anything over that can produce seizures.
Staying at this does and using the safe rec dose of codeine should be fine.

[Ale]

Originally Posted by waynemart

Max tram dose per 24/7 is 400mg. anything over that can produce seizures.
Staying at this does and using the safe rec dose of codeine should be fine.

That's exactly right if SWID's had seizures issues it's because of the whole 500mg at once ..Codeine has nothing to do with it

[Ale]

Originally Posted by Ethyl

Swie is using opiates again in a daily basis for 3 weeks, and he's got now quite a small tolerance. I've seen him using mainly codeine and tramadol, and during that time he wanted to be on the nod at least everynight after a days work..
He was taking (cause he stopped/winned himself since yesterday) doses of 300/350mg tramadol with very little euphoria, but he didn't want to take doses of more than 400mg, so he started mixing the codeine. Here is what he found best:

He would take the dose of tramadol, then he would wait for the peak (around 2.5 to 3 hours later) and then he would boost his nod with a small dose of codeine.

This will add sedation to the tramadol nod and add other types of opiate effects that are not present in tramadol. It makes tramadol feels more of an opiate.

Swie is very happy with this combo.

Faultless.SWIM's been told there's nothing finer than Tramadol&Codeine to enanche each other's effects

[Ale]

Originally Posted by Ethyl

He would take the dose of tramadol, then he would wait for the peak (around 2.5 to 3 hours later) and then he would boost his nod with a small dose of codeine.

Just a question...how much would that be?