7-hydroxy-mitragynine vs. tetrahydropalmatine

[sam o]

Hello,
I'm looking for a natural alternative for sedatives or tranquilizers, the two that seemed very interesting were 7-hydroxy mitragynine and lower dosages of tetrahydropalmatine, at there corrective dosages are these two at all similar? if not, elaborate please

Thanks.

[Ontherooftops]

I've never heard of tetrahydropalmatine, now I'm curious.

SWIM tried 7-Hydroxy-mitragynine and said it was excellent. Each dose produced a warm rushing sensation, similar to hydrocodone but "cleaner" feeling, followed by a mild sedation. Successive dosing resulted in the return of the rushing sensation, followed by increasingly heavy sedation. There's more to be read about it on erowid if you look around a little in the experience reports.

SWIM once acquired a small vial of isolated kratom alkaloids as well that was excellent. SWIM noticed insuflating a tiny line produced pleasant opiate effects for about 2 hours, larger or successive doses resulted in a pretty full blown opiate high. Reminded SWIM of about 30mg Oxycodone.

Really the high grade extracts are a little unnecessary though IMO. A good kratom resin extract is really pleasant and relaxing.

But kratom is much more like an opiate than a sedative or tranquilizer, even if it can be rather sedating. SWIM would really like to find a good natural benzo sort of thing and valerian and kava really don't cut it. Recently SWIM heard some interesting things about high grade extracts of wild lettuce but isn't so ready to believe them.

[Bajeda]

7-hydroxy-mitragynine

7-Acetoxy mitragynine

Tetrahydropalmatine

[snapper]

7ho mitragynine is expensive and has stimulant effects for a lot of people. It has a strong high which is habit-forming. SWIM has not found it to be conducive to sleep.
However, THP is cheap, knocks swim out and does not have any high, compulsion for abuse or hangover. It is not recommended for everyday use, however since high dose regular use of corydalis and THP extract (THP is the active ingredient in corydalis) has been shown to cause liver damage in some...

[Bio-Cellular Enigma]

Originally Posted by snapper

7ho mitragynine is expensive and has stimulant effects for a lot of people. It has a strong high which is habit-forming. SWIM has not found it to be conducive to sleep.

However, THP is cheap, knocks swim out and does not have any high, compulsion for abuse or hangover. It is not recommended for everyday use, however since high dose regular use of corydalis and THP extract (THP is the active ingredient in corydalis) has been shown to cause liver damage in some...

Just out of curiosity, how does one determine a "proper" dose of corydalis? SWIM had acquired some cordydalis powder in the past, but could not figure out what sort of dose to take... so he was too nervous to try it, for the reasons SWIY mentions above.

[snapper]

SWIM will use anywhere from 100-400 mg of THP extract (80%). Corydalis root could start with 1-2 grams and work up. SWIM experimented to determine what the best dose for sleep is but did it mostly with the extract since it is easier to ingest. SWIM insufflates it so that it kicks in fast - it is crystalline and does not burn at all.

[sam o]

A bit confussed here What would happen if a SMALL dosage of Tetrahydropalmatine was injested ?,Would it just take the edge off(like a benzo)and act as a mild sedative? or doesn't it work in this manner?

Thanks.

[snapper]

It is a non-euphoric mild sedative and pain reliever. No high at all, no real anxiety relief, but does induce sleep and helps control pain. It is a strong sedative at higher doses, btw.

[sam o]

So, there would be no reason to take this during the day ,unless your looking to catch some ZZZZZZ's.I just thought the effects might not induce sleep, with a small dosage ,maybe just take the edge off.

[DeleteriousEffects]

Originally Posted by sam o

So, there would be no reason to take this during the day ,unless your looking to catch some ZZZZZZ's.I just thought the effects might not induce sleep, with a small dosage ,maybe just take the edge off.

From what I found on the web, it's utility in being used to 'take the edge off' probably depends on how sharp that edge is...

THP interferes with dopamine, possibly by in the same NT way that that antipsychotic drugs (thorazine, etc.) work. If that's correct then it's not only not a fun substance, it's anti-fun. Dopamine=good.

http://www.clinchem.org/cgi/content/full/45/2/229

[Handle]

Yes, but my swim just bought two large amounts of the stuff [corydalis], sadly they were not powdered, and had to crush the little slices in a mortar and pestle, took 12 grams minimum just to be sure, got no effects.

Now, I know it has not really worked for people in opiate w'drawal, but my swim wasn't in w'drawal, he was just on maintenance bupe, but there must be something going on. Just because it has cross tolerance with morphine doesn't explain how it could be blocked by bupe. And anyway, think about this, even people with a strong tolerance to morphine itself will still get an effect if they use enough, so what's going on here with my swim and his corydalis? Can anyone explain the mechanism of its action or blocking?