Herbs as Enzyme Inducers.

[Ethyl]

As you can see acording to this study taking valerian induces more CYP2D6 activity from 123.6%(+-4.4) up to 141.1%(+-3.2). 100% is normal CYP2D6 activity

Ginkgo biloba in low doses decrease CYP2D6 activity but in high doses it increases up to 143.4%(+-6).

So valerian would increase swiy's lab rats livers codeine to morphine conversion by up to 43%... Swie lab rat is going to be tested by swim with valerian in his next codeine experience.

Full article: hxxp://www.blackwell-synergy.com/doi/pdf/10.1111/j.1742-7843.2007.00011.x



EDIT: although CYP3A4 is more increased...
Gingko biloba in high doses decreaces CYP3A4 to less than half (less than half norcodeine) and increases CYP2D6 activity to 143% (up to 43% more morphine).

[Ethyl]

However this study is in vitro, not in vivo, and...

To our knowledge, this is the
first study to assess the inductive properties of common
valerian on CYP enzymes in vitro. Two recent reports have
investigated the effects of common valerian in humans and
found no effect on either CYP3A4 or CYP2D6. Donovan
et al. [50] say that common valerian is unlikely to produce
interactions with CYP2D6, but they draw no categorical
conclusion. The study focused on inhibition, but should also
observe induction, if any. CYP3A4 activity is also unaffected
in the study, using alprazolam as substrate. Gurley et al. [21]
seem to have used a product lacking the marker compound
valerenic acid in the study and suggest that their result might
not be representative for other valerian products.

[Jatelka]

SWIY may find this article from the archive interesting:

http://www.drugs-forum.com/forum/loc...d=2106&catid=8

[Ethyl]

That is the Donovan study/report that i mentioned in my second post.

[Ethyl]

Swie just got some valerian extract (pharmaceutical quality), he also has a pack of gingko biloba tea at home. He will try see if any effects happens next time he is doing codeine for fun, today he his weaning himself with help from tramadol/bromazepam. next week he told he would probably be fine to experiment and then i will report in here.

[Paracelsus]

Maybe daily intake of Ginkgo biloba extract (sold in pharmacies for cognitive enhancement) with occasional use of codeine would be even better than codeine and ginkgo tea. There's a big Ginkgo biloba growing near my house, but I read somewhere that properly made extract is healthier than plant material (a certain toxin present in the leaves). So SWIP would stick to pharmaceutical Ginkgo.