Anticonvulsant for opiates

[delphinen]

SWIM was wondering if anticonvulsants such as Neurontin would help against possible seizures with Opiates (Tramadol, Codeine, etc.)

Reputation Comments on this post:

Great Question

[Jatelka]

Opiates are well recognised to cause seizures (independant of withdrawal)

SWIJ has uploaded some stuff to the archive

http://www.drugs-forum.com/forum/loc...=1858&catid=24

http://www.drugs-forum.com/forum/loc...=1859&catid=24

Please do NOT self-medicate where seizures are concerned. Please see a physician.

[delphinen]

actually, SWIM is using 0.25mg Clonazepam every time SWIM takes large amounts of opiates to feel himself at least a little more secure, SWIM already had a seizure because of 500mg Tramadol and 120mg Codeine, and even if SWIM knows that was a lot, SWIM wants to be sure now, even when taking lower doses ; problem is Clonazepam its not really easily available for SWIM, thats the reason because SWIM was thinking in another GABA drug that would be useful

[Fantasian]

Someone at risk of seizures should not really be on any strong opiates especially in the doses your talking about. Seizure and convulsions can be exceptionally dangerous and unless SWIyou have a medical reason to take them (which im guessing SWIY doesnt as he doesnt have access to anti-convulsants) they're best avoided.

[delphinen]

did you read the part where SWIM says SWIM knows that was a lot, SWIM wants to be sure now, even when taking lower doses
SWIM is doing 250-350mg doses now, without Codeine, and with the Clonazepam

[Fantasian]

Originally Posted by delphinen

did you read the part where SWIM says SWIM knows that was a lot, SWIM wants to be sure now, even when taking lower doses
SWIM is doing 250-350mg doses now, without Codeine, and with the Clonazepam

Yeh, the dosages SWIY were talking about SWIF would say were extreme.
In SWIF's experience anything above 200mg was a high dosage. From what i know 50-100mg is medical dosages. SWIF found a ceiling effect in euphoric and analgesic effects at about 200mg. Tramadol however isnt really a good euphoric substance especially for someone who suffers from convulsions from opiates. The pleasure in SWIF's oppinions really isnt worth the risks.

[delphinen]

I dont want to convert this thread into a Tramadol discussion, but I dont agree with you:

[xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxTramadol's cis analog is a VERY WEAK analgesic, if at all, and all non-phenolic analogs of tramadol reported thus far have been inactive. The importance of the phenolic function suggests that tramadol type is closely related to morphine, and orientation of their basic group aromatic features mimics that of the alkaloid. Concerning M-1 (0-desmethyl), if you transposition the aryl and one of the alpha hydrogens of the aminomethyl side chain with each other, you get quite an active compound (ciramadol). It is about 2X morphine in standard rat tail flick test, but is partial agonist/antagonistic. Even though it is more potent than tramadol, it produces very little euphoria. For those who properly metabolise tramadol, psychic effects can be the pinnacle of the opioid experience (even rivaling ketibemidone).[/quote]


NEXT TIME REMOVE THE LINK TO OTHER FORUM(S).

[Female]

Eh, sorry about resurfacing this thread, but SWIM has a question that wasn't easily resolved by reading up on what was already available. SWIM understands that Tramadol can and does lower the seizure threshold. As far as SWIM goes, she has never EVER exceeded the 400mg maximum dose of Tramadol and has never gotten any seizures from Tramadol, or any other opiates. SWIM has no predisposition to seizures and has never experienced one.

However, SWIM is now on a low dose of an SSRI (celexa) 10mgs a day. She has only been on this medication for around 3 weeks. SWIM KNOWS the risks involved with taking Tramadol (especially) and an SSRI, which is why she has been completely abstaining from Tramadol (the only opiate-type drug she has readily avaliable). Swim is not saying she will do the following; swim merely wants to know if it is possible. Swim values her health much more than to risk seizures if tramadol + ssri would equal this.
SWIM also knows about the risks of serotonin syndrome, and would like to add that she has mixed DXM (doses lower than 250mgs) with her 10mgs Celexa daily and has received no ill effects from the combination. SWIM is more worried about risking seizures as she wouldn't be taking large amounts of tramadol (exceeding 250mgs) to begin with while on 10mgs, so she believes, due to her research, that the serotonin syndrome would be a lesser problem than the seizures respectively, on these lower doses.

Swim also has readily avaliable several anti-convulsants, such as Zonigran/Zonisamide (believe that's the proper spelling), Keppra, and Potassium Bromide. Would taking a small dose of one of these medicines raise the seizure threshhold effectively enough to be able to take a smaller dose of tramadol while still taking the 10mg celexa? Any and all information would be appreciated. Again, Swim is NOT saying she will do this, nor is she saying it is a good idea or a healthy one, swim understands the risks involved, but merely wants to know if this combination would be helpful.