Indopan in USSR

[Rush]

Just searched for AMT use in the USSR as an anti-depressant.
Here are some abstracts of researches conducted in Russia.
An interesting point is that most of those researches arent headed towards demonization of the drug or trying to find all reasons to ban it(like what happened to MDMA), like most of the western research is(USA & Japan), but searches the true benefits of the chemical.
Unfortunatly many of those articles(the most interesting ones..) don't even have an abstract avaible, or needs some subscriptions.

[Acute and latent influenzal infection in mice with altered endogenous serotonin metabolism]

--Notes: here AMT is used in "nontoxic" doses(i think it means below 15-10mg) to raise serotonin demonstrating that high levels of serotonin causes decrease of resistance to influenza virus---
[Article in Russian]
Popenenkova ZA,
Zuev VA,
Romanovskaia MG,
Maslennikov GA.
A steady and long-term increase of the endogenous serotonine concentration in the lungs, spleen, and brain achieved by administration of nontoxic doses of indopan, an inhibitor of monoamineoxidase, caused a significant decrease of resistance of animals to influenza virus in acute infection. After natural route of inoculation with 20 LD50 of the allantoic influenza A3/WSN (HON1) virus strain in the animals treated with indopan the area of lung affection with specific influenza pneumonia increased, the virus concentration in the lungs and spleen rose sharply, the titre of IgM antibody in the blood decreased; the animal mortality in this group also increased. The level of serotonin in the blood and organs of latently infected animals became normal 6 weeks after virus inoculation. In some of these animals, however, indopan caused a greater increase of serotonin level in the lungs than in intact mice of the same weight and age. Without changing the amine levels in the spleen and the brain, indopan caused 4-16-fold increase in the titer of specific antihemagglutinins in the blood, mostly of IgM fraction, as compared with the controls. In latent influenza infection the balance of serotonin metabolism in the lungs in unstable.
PMID: 919502 [PubMed - indexed for MEDLINE]

[The effect of several psychotropic substances on brain structure]

[Article in Russian]
Popova EN,
Krivitskaia GN.
The authors have shown similarities of structural changes in the neuron and interneuronal relations found in the brains of rats under indopan and LSD stimulation of the CNS with certain differences in the localization of the changes in the functionally different brain systems. A high sensitivity of the sensory-motor cortex and the subcortical formations of the brain, rich in dopamine and serotonin, to indopan has been marked. LSD central effects were conditioned by the influence of the drug not only on the synapsis, but on the cell body components of the different brain systems, especially in the visual. The observed changes were allocated to categories of functional disturbances.
PMID: 1210984 [PubMed - indexed for MEDLINE]

[Effect of monoamine oxidase inhibitors on the phagocytic activity of macrophages]

[Article in Russian]
Maslova TN,
Dunaeva VV.
Preparations studied in this work with the properties of monoaminoxidase (MAO) inhibitors caused a reduction of the phagocytic activity of cells and degeneration of the cell culture. By the extent of the toxic action on the macrophage culture the preparations could be distributed in the following order: chloracizine, chlorpromazine, vetrazine, indopan; biogenic amine serotonin influenced the phagocytic activity of cells only in very high concentrations. Macrophage cultivation in a medium containing MAO inhibitors led to quantitative and qualitative changes in the acid phosphatase granules. Reduction of the phagocytic capacity of macrophages and the changes in the lysosomal apparatus of the cells proved to depend on the increase in the concentration of the inhibitors in the culture medium and the duration of their action on the macrophage cells.
PMID: 1124612 [PubMed - indexed for MEDLINE]


Other interesting stuff, but with no abstract avaible:

[EFFECT OF INDOPAN ON THE BIO-ELECTRIC ACTIVITY OF THE BRAIN.]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1963;63:1679-87. Russian. No abstract available.
PMID: 14211279 [PubMed - indexed for MEDLINE]

[APROPOS OF THE USE OF INDOPAN IN CLINICAL PSYCHIATRY.]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1964;64:768-70. Russian. No abstract available.
PMID: 14138128 [PubMed - indexed for MEDLINE]

[Group toxicity of indopan and its reaction to various neurotropic drugs]
Farmakol Toksikol. 1965 Jan-Feb;28(1):23-7. Russian. No abstract available.
PMID: 4378916 [PubMed - indexed for MEDLINE]

[Influence exerted by indopan on conditioned reflexes in rabbits]
Farmakol Toksikol. 1965 Aug-Sep;28(4):394-8. Russian. No abstract available.
PMID: 5868398 [PubMed - indexed for MEDLINE]

This is also interesting but needs access:
Search for new antidepressant preparations and study of the mechanism of their actions JournalPharmaceutical Chemistry JournalPublisherSpringer New YorkISSN0091-150X (Print) 1573-9031 (Online)IssueVolume 12, Number 2 / February, 1978CategorySearch for New DrugsDOI10.1007/BF00778359Pages182-193Subject CollectionMedicine SpringerLink DateMonday, December 13, 2004
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Nobody knows anything about Indopan when was avaible in Russia?

Reputation Comments on this post:

good research

[nanobrain]

Indopan aka IT-290 was prescribed as an antidepressant in the 1960's-70's and phased out completely by mid-1980s due to an, ahem, interesting side effects profile.

[Rush]

Originally Posted by nanobrain

Indopan aka IT-290 was prescribed as an antidepressant in the 1960's-70's and phased out completely by mid-1980s due to an, ahem, interesting side effects profile.

because it was also a psychedelich drug, that's what you mean?

[nanobrain]

yes, the grannies were getting 'super-antidepressed' for hours on end...

[rikki_tikki]

Nobody knows anything about Indopan when was avaible in Russia?

SWIM is currently in Moscow, and he sees Indopan as being available in a number of online pharmacies in Moscow. The description mentioned above doesn't make a whole lot of sense to SWIM, at least right now, it being 5 in the monring. Do you think it would be worth his while and money to buy some and test it out? What would you expect as the predominant effect after taking some?

[rikki_tikki]

I mean... someone who totally isn't me might be currently in Moscow, and he may likely have seen Indopan available in an online pharmacy... and he was
hypothetically wondering of the possible effects of accidentally ingesting said substance after mistaking it for Aspirin.

[Nagognog2]

If what SWIM sees is actually Indopan - a-Methyltryptamine - then some research of a-MT or AMT in the forums will show one that in dosages ranging from 30mg to around 50mg (some people do more, but should always start low for safety's sake) will produce a psychedelic journey lasting upwards of 24 hours.

As this substance is a MAOI (monoamine oxidase inhibitor), it is mandatory to read up on the pre-cautions to take to avoid a toxic reaction.

[Rush]

you probably found this:
Indometacin(trade name indopan)
here is why:
http://translate.google.com/translat...%3Den%26sa%3DG

Or if you can read russian:

http://www.webapteka.ru/drugbase/name2601.html

Indometacin info:

http://en.wikipedia.org/wiki/Indometacin

its a FANS like aspirin

i know this cause when i was searching for infos about indopan in russia i found out that there was another drug called in the same way but that was a completely different thing.
BTW shares the indole skeleton with AMT...probaly that's why they have the same name.

also there is this conflicting page:
(english)
http://translate.google.com/translat...%3Den%26sa%3DG

(russian)
http://www.medtrust.ru/pls/farmsprav...ObjectId=16538

what i found conflictual here is:
Фармакологическое действие : Антидепрессивное, психостимулирующее
(google translated..)
The drugs act : Antidepressivnoe, psihostimuliruyuschee
That means Antidepressant , psichostimulant

and that seems more AMT than a FANS...!


However if SWIY could test this it would be better.
i think that indopan/indometacin you found is even OTC


and also if you could find more info about AMT(real indopan) as an antidepressant i would be very glad

like some research or articles or something which found some side effects that pulled it out of the market...i mean...what they found to be so bad that made them stop!

Reputation Comments on this post:

good post

[nanobrain]

its not the same indopan if ya look closely. the one avail now has zero psychoactive fx, it is an Indian product i forget what for.