Drug info - Cross Tolerance: LSD and Other Stuff

[Curtains]

Jatelka EDIT: This is a combined thread and the earlier posts are from before the "No Self Incrimination" rule came into play

I did acid for the first time not to long ago and i was wondering if DXM tolerance is someway related to LSD tolerance
becuase when my two friends took 2 hits and i took 3 they fucking tripped hard as shit mad visions and shit. I on the otherhand barely tripped no visions at all just that sorta tripping feel
Our doses were exactly the same watched the guy but it on the paper and i took and extra

Now my DXM tolerance is though the roof 400mg barely fucks me up now...ANy chance these are related

[serotonin]

i have never heard of anything like this, but now that you mention i think it is entirely possible. i also have an extremely high dxm tolerance, and just two days ago something similar happend to me. i took two hits of what was supposed to be very good acid. while my friends tripped their asses off all i got was about the same thing as a 3 gram mushroom trip.


it's certain that mushrooms and other pyschedelics cause a cross-tolerance with eachother. there is no doubt that dxm has some psychedelic effects. it brings up an interesting point.

[Curtains]

i thought i remeber reading something about how DXM and LSD use the same brain receptors just in different ways...wish i could find that again

[Bodhisattva500]

Is lsd tolerance true, how strong is it? Do you have do take almost twice as much if you trip two days ina row?

[RoboCop]

That seems very possible Curtains, for me tripping on dxm so much at such high plateus all the time, makes every other drug I do seem so much weaker than it used to. Im used to that STRONG dissociative buzz, nothing can meet my expectations anymore, I have to take high doses on any drug to feel satisfied and at my body weight I really shouldn't have to (135LBs, 6ft)
Of course salvia D. is an exception, nothing overpowers that shit.
However if I mix drugs with dxm I seem to always have a satisfieng trip, for example, dxm+lsa (was powerful) dxm+shrooms (powerful), If I had some lsd i'd do that with dxm. DXM potentiates every hallucinogen I have ever tried to mix it with.
(anyways my problem is different than yours but similiar so I figured I'd post it here)

[RoboCop]

Well this is what I foudn on the subject through erowid.
"Regular use of DXM may alter the effects of LSD due to overall increase in 5HT binding and decreased 5HT2 receptor binding."
Looks like regular use of DXM does alter the LSD experience.

[Ziro]

Don't forget the placebo effect.. you're friends could very well have been exaggerating, and you're just being honest.

[Henfer]

Hi everyone..

do you think LSD has some kind of cross tolerance, affecting other drugs as well for 1-2 weeks after tripping?

SWIM had sime 8g of good shit and smoked some of it and got very high, and smoked on with same effects for 3 days. then he took ~200 micrograms LSD, nice trip etc. as usual. But since that day (5 days ago) even smoking 2-3 grams of this weed does not really kick in good.

SWIM has heard of LSD also raising tolerance for shrooms and mescaline.. but weed?

What does SWIY think?

[Solidly-here]

Swi-Solidly-here has no tolerance issue with Pot.
Any time, before (or after) anything else . . . It works just fine.
Usually, the day after a Trip, some Pot is ingested, but that's just for Afterglow.
It helps to bring-back a taste of Trippin. Mmm.

[chAos]

Swim thinks it has noting to do with the lsd. He thinks that swiy just has been smoking much the last days. If he wasn't smoking daily untill he bought the 8 g, tolerance might have started to bould up after 3 days. Smoking daily gets swiys tolerance up rather fast (certainly if swiy already smoked much in the past).

[Henfer]

SWIM's been smoking almost daily for months before as well. But the days before the trip SWIM also smoked a lot, thats right.

really not fair, having to wait weeks for a new acid trip and even smoking weed doesnt kick in. SWIM doesnt do other things anymore and won't do (mostly due to a single horrifing meth experience).

Does SWIM really need to wait 3 weeks to get the same hit from 200 micrograms again...?

[fnord]

my friends been doing ALOT of trippy things this month pretty much every other day,mushrooms 2ce 5-meo-amt lsd dmt 5-meo-dmt DOx mdma mda etc etc etc among 8-12mg 5-meo-amt gave nothing besides a speedy effect and everything just looked a lil bit different,how long untill my friends body goes back to normal?does tolerence build up for all trips,or just whatever substance that was used?like if my friend used a chem he hadent done in the past month would this effect him as hard as it should or would it be effected by some sort of cross tolerence?

[tayo]

there's cross tolerance, usually two weeks is okay to get over that. but there can also be a tolerance to the thought patterns and type of thinking, just like if swif starts to think like that all the time and it won't be as pleasing or will take more substance to reach a different mind state.

[podge]

Some drugs do have cross over tolerance, eg.... taking LSD, mescaline, or mushrooms will create tolerence to the other's. Swim presume's that 2ce would give tolerence to other phenethylamine's but isnt sure.

[Benzeneringz]

I'll just add really quickly that serotonin agents like LSD and psilocybin cause a significant (albeit temporary) downgrade in the number of 5-HTP2A receptors. Coupled with the temporary depletion of serotonin, this produces a type of tolerance. This is why there's a reduction in qualitative effect when a serotonin agent is used repeatedly over a short peroid of time. It's always a good idea to wait 48+ hours before taking a serotonin agent again if you want to get the same effect as the initial dose. There's also the added benefit of returning to a psychological base-line when the doses are spaced out in this manner. Repeated use of serotonin agents over a short peroid of time greatly increases the risk of psychological side-effects that comprise a 'bad trip'.

[LEC]

Originally Posted by Benzeneringz

It's always a good idea to wait 48+ hours before taking a serotonin agent again if you want to get the same effect as the initial dose...Repeated use of serotonin agents over a short peroid of time greatly increases the risk of psychological side-effects that comprise a 'bad trip'.

Would acid and X both count as serotonin agents? My friend had a question similar to this awhile ago because she had gotten 4 hits of acid and an ecstacy pill and was planning on doing them a day apart but worried that it would be a waste. Would she be correct in spacing them out more than one day even though she isn't a frequent user (and doesn't plan on doing anything else until Sept?) or will it not matter because they are different?

LEC

[fnord]

thread derailed...

regardless of how much she uses she should wait at least a few days,or do them all at once,if she likes mixing such things.

[ima-do-proprio-ser]

well,if my llama takes a xtc pill,and two days later an acid,will the acid effect be smaller ?

[Nagognog2]

Possibly. Your llama should wait at least a week between excursions induced by serotonergic molecules.

[shroomer1186]

Recently SWIM took high does of DXM 3 times over a week. Then a day after the final DXM trip took LSD and nothing happened. This person tried taking a higher dose of LSD the next day but only felt light 'tracer' effects. SWIM wanted to know if the use of so much DXM prevented him from having a true LSD trip and if waiting several more days before taking another dose of LSD would actually bring forth Acid's true effects. Depleted serotonin levels perhaps? SWIM would appreciate any help on this matter.

[psychedelicstan]

Not sure how DXM interacts with LSD, but never heard of problems before... did you take a lot of acid or just a small dose? And have you dosed from the same batch before (to have an idea of the potency)?

One thing to bear in mind: the body has a very strong LSD tolerance for a few days after you take it - three blotters can get you high on monday, but three on tuesday will probably not affect you much at all. From personal experience I'd say wait at least a week before taking more acid - the only way I know of to trip on consecutive days is to keep increasing the dosage each time, which is a waste of acid IMO.

So either way, don't take any drugs for a week or so and the acid should work. Unless it's low-potency acid, which is a bummer. Or unless someone who knows more about it than me can explain the weird DXM interaction anyway.

[shroomer1186]

SWIM also took Amanita muscaria caps, 12g for 2 days, before taking the LSD, could that have been a factor?

[shroomer1186]

Sorry to double-post, dont know how to edit. SWIM had also taken promethazine 100mg same day of first acid dose.

[Desertfox]

swim should consider slowing down and spacing his drug journeys farther apart.

[podge]

DXM and LSD and Amanaita Muscaria do NOT share any cross over tolerence.

The likely solution is that the LSD isnt very strong. And swim agree's with some of the above posters, swiy needs to space out their drug use, dropping different chemicals every second day isnt healthy and it guarantee's swiy wont get the optimal effects. Even though they dont share cross over tolerence .....the body still needs time to recover after drug use to be able to feel the full effects. Have at LEAST a week between uses.

Also the promethazine shouldnt have diminished the LSD effects.