Drug info - Propylhexedrine Basics, Part 2...

[EuPhOrIa89]

Swim takes Propyl about once a month. Swim takes about half of the cotton to feel stimulated. Its been a month now and swim still has the remaining half. The other half is still in its plastic tube and was closed tightly. If swim takes the other half will it be ok?? Can it lose its potency?? Swim doesnt feel like going out to get another one if swim doesnt have to. Thanks for your replies and insight!! Peace
Also swim noticed that the cotton(new/old) the cotton(about 80%of it) has a yellowish - brownish color. Also the center of it has a yellowish color too. What makes it that color?? Is it the Propl, Lavender Oil or menthol? Or all the above?? Thanks again!!

[Ranke]

Swiy should be fine with it. As long as it's kept in a closed container the propylhexedrine shouldn't have evaporated. As for the yellowish brown color, it is probably a mix of lavender oil and propylhexedrine. If I remember correctly amphetamine freebase is yellowish brown as is methamphetamine freebase, so it's likely that propylhexedrine freebase is as well.

[Nacumen]

Sometimes SWIM finds no brown spots in his propylhexedrine cotton, sometimes they're scattered faintly, and sometimes there's a huge brown coloring surrounding about a third of the cotton in the middle.

SWIM still hasn't slept since his last propylhexedrine experience starting 2 hours after the cotton's ingestion (1.3 cotton rods ingested at +00:00, 0.7 rods ingested at +06:00).

For SWIM, it takes about 1.5-2 hours to begin coming up on 250mg in the cotton rods, and at 3-4 hours he's plateaued. The euphoric effects last about 5 hours total for SWIM, but he isn't able to sleep for at least 10 hours after ingestion, usually 12, actually.

[melt_000]

SWIM's used this a few times. always good results, (it's the only real stimulant he's ever tried). He's not a big fan of stimulants overall, doesn't really like the feeling of being an insane overpowered machine, but sometimes in this life you have to do boring shit, and it's easier to take drug than to have willpower (for shame)

The only thing that makes him a little worried is the cotton thing. People always say it can cause an obstruction, but SWIM has never seen anybody on any forum claiming they've had such results. Even with eating the cotton whole, or even multiple whole cottons.

It would seem, though SWIM is no doctor, that cotton is a fiber, and theoretically it should be good for digestion in small amounts as it would sort of go through like a pipe cleaner... that's what dietary fiber is for right?

SWIM method is to pull apart (usually can't find scissors) about 15 pieces and eat it with something, like cotton / bite of sandwich / cotton / bite of sandwich, so it will mix with the food as it expands. That seems the best option for eating, no?

has anybody heard experience reports of people needing medical attention for intestinal problems related to this? I mean i've heard of vomiting but that's stomach not intestine blockage related.

alright SWIM starting to feel something must go do the studying for which he justified doing this again. or maybe (oh shit) he will end up posting for hours on various message boards and looking at porn oh well

[seanman05]

Would taking propylhexedrine along with some kind of pain killer and some kind of sleep aid at night work to prevent head pain and allow sleep? Also to prevent or lessen the crash? Please answer. Thank you.

[Ranke]

Originally Posted by seanman05

Would taking propylhexedrine along with some kind of pain killer and some kind of sleep aid at night work to prevent head pain and allow sleep? Also to prevent or lessen the crash? Please answer. Thank you.

If swiy is having head aches from propylhexedrine then STOP. That is a sign of increased blood pressure and swiy is risking serious health problems. Propylhexedrine is a very strong vasoconstricter and puts a lot of strain on swiy's circulatory system.

[Zarbot7]

SWM extracted 2 cotton rod's worth of propl using the miriatic acid and microwave method. Then dissolved the crystals in a shot of vodka and downed it on a semi-empty stomach. SWIM felt the effects MUCH faster than swallowing the cotton, this is probably the most effective way of doing it as snorting it is impossibly painful and injecting it is possibly fatal. SWIM does wonder if anybody has tried smoking it...

Reputation Comments on this post:

Good first post and nice use of swim

[Paracelsus]

what would be the chemical basis for this?

DXM is a sympathomimetic. SWIP personally can confirm that it significantly raises blood pressure (from 125/65 to 155/95 in about two hours).

While most people won't have problems with low doses of stimulants with DXM, high doses can be dangerous and so can be DXM+stims in people with heart problems and such.
Gravol, the editor of the DXM Zine reported he almost died from DXM + large amounts of dexedrine (snorted). Look it up.

Back on topic.

[Spelvin]

I'd like to ask people about this whole using glucose thing for an easy comedown. Swim really likes propylhexidrine but that numb, dumb, empty feeling swim gets later on makes swim not want to mess with the crap anymore. Does eating a lot of glucose-rich foods really work, and if so, what kinds of foods? Pastas, breads, fruits? Swim has no glucose supplements to try

[Ranke]

Generally the nasty feelings on comedown can be avoided for the most part by eating healthy food, drinking water, and taking vitamins. Swim usually takes piracetam,
(increases glucose uptake in the brain), selenium, N-acetyl-cysteine, and a multi vitamin. Although he still has minor crash symptoms, most are eliminated by this combo. But the most important thing of all those is water and if you're not taking a multi vitamin, replace water with a sports drink.

[Lucid_Dreamer]

Just a heads up on Propylhexadrine usage:

SWIM reports that he ingested one cotton rod of Propylhexadrine and later failed a drug test (13 hours later) for methadone, oxycontin, and barbituates.

So be safe when using. Make sure you don't have any drug tests coming up in the near future.

[Drakzon]

Abour your failed drug test, did they do a confirmation test. My company does a confirmation (at least swim thinks swim heard that they did swim definilty hope they do) test if you fail, at least swims pretty sure they do, swim is assuming though swim don't know if they use a gas chromatigraph which can identify the individual molequels (at least thats what swim heard) and is thus pretty much infallible. Does anyone have any information on wether or not you could fail both the initial drug test and also fail the much more sophisticated confirmation test. swim had never imagined that propylhexadrine could cause a drug test failure. Were you really not using any other drugs at the time, and had you not used any in say the past month cause swims heard of drugs being detected up to 10 (maybe even longer) days later, and swim thinks it's possible to detect drugs after even a longer period of absitence. So any information on possible drug use before you failed this drug test, and any information you have on the type of drug test that was given i.e Gas Chromatigraph which is the high end one, or just the drug test where you pee in a cub and they stick a paper in it which is much less accurate. Finally are you on any medicines for mental illness ie. antidepressants, mood stabilizers, antipsychotics, or anything similar. Both swim and Swims sister (she has never used a drug in her life) have had false positives, and these were at a time that I hadn't used drugs in over a year, and my sister has never used any drug. For somereason psychiatric medicines seem to cause false positives sometimes, but other times on them you'l test clean it's scary cause i'm on psychiatric medicine and my job does random drug tests. Any further information you could give swim would be a big help if it's bad news it may cause me alot of worry but i'd rather know and deal with the anxiety than not know.

[profaneprimate]

Is it known if the effects are actually increased by extraction, or is it basically the same as just mixing up the cotton in a glass of sprite or something?

[Spelvin]

Some things Swim does to avoid crappy comedown from Propylhexedrine:
taking some advice from Ranke (thanks buddy!) and doing a few other things swim now makes sure he has some glucose in his body by eating bagels or bread, takes multivitamin, 5-htp, rhodiola, ginger for stomach, drinks plenty of water and does not take the propyl on an empty stomach. Swim hasnt tested this at all, by isolating different factors or anything, but it does seem to help out a lot swim hasnt crashed badly since going this route.

[tillicollpase]

SWIM is also a big fan of benzedrex, and mainly uses them as study aids. SWIM's method of preparation is to simply cut into 9-10 small peices and parachute in two attempts. SWIM makes sure to eat something before taking the benzedrex, as this helps with the lavender burps and slows absorption. He also drinks plently of WATER before and after dosing. SWIM's usage of benzedrex is mainly for studying. SWIM has focus like none other, and by slowing absorption he staves off the feelings of euphoria (which just cause him to want to be social and actually lose focus) but promotes the feelings of focus for probably a good 8 hours. The cotton also helps with this time release, since the propylhexedrine must be leached out from a definitive source, allowing for diffusion laws to drag out the dose, while an extract would hit the stomach and disperse much faster, allowing for faster absorption. SWIM usually takes his on a saturday morning, to help with "Super Saturdays", in which he gets all his course-work done for the following week.

A note on the cotton debate. Cotton is effectively 90% cellulose, and humans can't digest the beta(1,4) glycosidic linkages. However, the hydrogen bonds holding the "sheets" of cellulose of cotton together can be easily cleaved by the acidic conditions of the stomach (ph ~ 1-4). Assuming a retention time in the stomach at thesecoditions for about 2 hours, at least, this would serve to greatly reduce the firmness of the origional structure, creating less of plug and more of a "mash". Try it with a solution of dilute HCl, with a pH of 2-3. THe cotton will obviously balloon, given cellulose is hydrophillic, but after the expiration of 2-3 hours, it might still look very much the same, but it you pull it out and play with it, you can see the difference in how the fibers hold together, compared to just leaving it a glass of water for 2-3, in which it will only balloon up, and still hold together well. Further, plant cotton is contaminated with hemicellulose, which further allows the for the cotton to be weakened. Just be sure to cut the peices sufficiently small, and SWIY should be fine.

SWIM also uses an antacid (4 extra stength tums, immediately prior to ingestion of parachutes) to help with the absorption of the propylhexedrine. Once in the stomach, the compound, which its freebase form (a weak base), will inevitably form salts because of the acidic conditions. The freebase is the only way the compound will be absorbed through the membranes of the gastrointestinal system. By taking the antacid, stomach pH is increases, shifting the equilibrium towards the desired freebase form. Yes, this does increase the rate of absorption (which is contrary to SWIM's goal of slowing it), but it also increases the bioavailability. The effect is small, maybe only a few percentage points, but still, once the threshold dosage for the effects has been reached, using this method for greater absorption serves to extend the effective half-life of the drug. In pharmacology, half-lives, are not absolute: they are dose dependant, with higher doeses resulting in effectively longer half lives. And this is a longer half-life of a bigger whole (dose is bigger), so the time spent above the threshold is increased. Urine pH affects it half-life too; acidic urine means shorter half life. The antacid SWIM have heard can help with alkalizing the urine, and even redosing with 2-3 more tums like 3 hours after the inital dose is something to look into. SWIM's been working on trying to find good journal articles on how much urine pH actually has an impact on half life, and concurently, how much asorbic acid (vitamin C, found in a lot of beverages) effects urine pH.

Btw, this digestive/excretion pharmacokinetics is based on amphetamine and methamphetamine studies. But, clearly based on the amazing structural-similarity and anecdotal evidence of similar pharmacodynamics, SWIM thinks the assumptions are valid.

[pipolito]

Is Propylhexedrine available in Canada ? If so, is it OTC ? What are the available brand names ? I found that is was Schedule V..... What exactly does Schedule V mean ?

Thanks

Reputation Comments on this post:

Stop cross-posting!

[HighParadise]

Originally Posted by pipolito

Is Propylhexedrine available in Canada ? If so, is it OTC ? What are the available brand names ? I found that is was Schedule V..... What exactly does Schedule V mean ?

Thanks

Schedule V means it's termed the least abusable by the US government (besides non-scheduled chemicals). There's a thread right next to this one called "Is propylhexedrine legal in Canada?" that should help you...

[fiveleggedrat]

So. Swim has been holding onto a handfull of inhalers he picked up last month.

Stimulants are NOT Swim's forte. However, Swim's drug rotation is suffering at the moment. "Pot today, Benzo day after, Opiate day after, repeat" is getting boring. Swim does not want to take his opiate use to the next level (IV) either.

Anyways, like Swim said, he is not big on Stimulants of any type. He has done coke probably 100-200 times from when he used to sell and test it always. He's had pure and he's had amphetamine that shoulda been coke. He's also had BZP, his first ever stim. Swim wants something euphoric, and has had a hunger for coke lately, but he thinks coke is insanely overpriced, and would only buy if rich.

Swim hears such nice things he got the inhalers a few months ago. After reading the chem extraction basics on this, Swim decides to do the following:

1 Inhaler, cut into 7 pieces. That is 250mg. Swim dumped pieces into HOT almost boiling water, Swim stirs till most cotton starts to break down/dissolve/fall apart or whatever you could call it. Swim dumps eyeballed, large amount of powder citric acid (from grocery store) into solution. Swim stirs for 10 minutes, grabs the floaty cotton mess and squeezes it all dry, and tosses it.

So solution is currently drying in a pyrex pot under a lamp. Swim can see white stuff floating around the bottom of the pot. Swim'll dry this out hopefully today (heat lamp maybe?) and try it, and post yields as well.

Edit: Swim's experience with above is posted in the "Propylhexedrine Experiences" thread.

[Psychoactive Lab Rat]

SWIM thought it'd give it's 2 cents to the subject, as it's an avid propylhexedrine user. SWIM has experience with a lot of the amphetamines, dextro and meth, as well as experience with quasi-stimulants like methylphenidate.

SWIM has spent hours writing in it's usage journal about the effects of this chemical. Propylhexedrine by it's self it is a pleasant euphoriant, able to alter perception and give the user a short-lived amphetamine like high. Concentration is notably increased, as is motivation. SWIM has also found that a 250mg dose of propylhexedrine is probably a very high starting dose for the avid experimentalist. Seeing how the inhalers are impossible to dose correctly, there is really no way to solve this problem, unless you take the extraction route. The extraction route is pretty pointless too because the yields are so low, and it's time consuming.

Advice for new users:

Take a whole cotton, 250mg of propylhexedrine will not hurt you on it's own if taken orally, but it will give you a pretty good idea as to what this substance can do. Expect to be "high" with a 250mg dose of propylhexedrine. If your young, it's not advised to be around your parents (pupils have been known to dilate whilst taking propylhexedrine) this could cause obvious problems. Otherwise, SWIM has found most activities pleasant while on propylhexedrine, gaming, reading, studying, listening to music.. hell, even yard work. SWIM once spent 8 hours laying grass seed and raking it in to a baron dirt lawn, smiling the whole time, enjoying SWIM's self.

As with any psychoactive substance, be mindful of your body. If you feel as if your loosing control of the subtle things your body controls, such as heart rate, breathing or anything else equally scary, go get yourself checked out. You never know what kind of dormant issues lay underneath your gene pool. Stay away from all other stimulants, and MAOI, you know... the usual stuff. SWIM won't insult your intelligence and if you don't know what I'm speaking of, maybe you should do some research of your own?



Advice for experienced users of Propylhexedrine:

There are a couple of theories SWIM knows as truth from it's experience and trials with this substance.

1.)Propylhexedrine is most likely metabolized by the CYP2D6 enzyme, proof of this is when taking Cimetidine (Tagament) and Bupropion (Wellbutrin) in combination with Propylhexedrine the duration of the substance is increased/amplified. Cimetidine and Bupropion (when broken down into Hydroxybupropion by the CYP2B6 enzyme) are both CYP2D6 inhibitors, (Hydroxy)-Bupropion potentially being the stronger of the two.

SWIM noticed a 3-5 hour increase of positive (wanted) effects from Propylhexedrine when used in combination 150-300mg Bupropion and 5-10mg dosing of Cimetidine.

HOWEVER...

SWIM has read other experience reports that the combination of Bupropion and Propylhexedrine can lead to adverse side effects, so SWIM is in no way condoning the use of these two substances together, use at your own risk.

SWIM will only state that this combination has been taken well over 100 times during the time frame of 1-2 years. Sometimes using both Bupropion and Cimetidine, and sometimes using only one. SWIM states that once he has had experience with Propylhexedrine + Bupropion he will never do Propylhexedrine without Bupropion ever again, "It's just not the same."

2.)The best way to take the inhalers is as follows: Go to your local pharmacy or health store and find gel capsules, 1000mg gel capsules. If SWIY cannot find capsules, buy suppliments that can be easily taken apart, and emptied to be able to use the capsules (Lipozene works wonders, easiest capsule SWIM ever "unscrewed" and emptied). Cut the cotton rod into 7-8 triangle shaped peices (by cutting at an angle on the rod) and stuff the cotton pieces into the capsules on at a time, using the end of the scissors to push the cotton into, packing, the capsule. Close the capsules and then ingest. No taste, no swallowing horrible textured cotton rods.

3.)Propylhexedrine shouldn't be used daily. It just doesn't work, period. The side-effects/rapid tolerance to the substance make it impossible to enjoy on an every-day basis. Limit yourself to every other day if your using this substance to battle depression, lack of concentration/motivation. SWIM would also suggest adding Bupropion to your medications as it will help the positive effects of the Propylhexedrine, one by inhibiting the CYP2D6 enzyme from breaking down Propylhexedrine so fast, and two Bupropion is used to treat various forms of depression because of it being a dopamine and noradrenaline re-uptake inhibitor, this action could potentially enhance positive effects of Propylhexedrine in some circumstances/environments.

4.)Alcohol in SWIM's experience enhances Propylhexedrine's euphoria, in the same way as it would other amphetamines. SWIM has not researched significantly to provide a theory as to why this is, but there are plenty of psychopharmacologists out there that have made connections between stimulants and alcohol. I would suggest you read their work if a answer is needed.



Hope this helps someone, SWIM has always wanted to do a Propylhexedrine FAQ, but it has never got around to it. Perhaps one day SWIM will take the time to properly hook this unique substance up.

Reputation Comments on this post:

great first post! keep it up

[justgotmessup]

FYI

If your going to go out and buy some Benzedrex, rethink this, that cotton inside is going to taste like lavender oil, try to consider cutting the cotton in small peaces and find a old herb or medician bottle in your bathroom mirror that has capsules in the bottle. empty the capsules out and put the small peaces of cotton in them. Then just swallow the capsules. Trust me, it works awesome.

[nick760]

Would propylhexedrine be detectable in hair drug tests?

SWIM heard that it can cause a false positive on urine tests, but wanted to know about hair tests. The reason he explores these 'legal' alternatives in the first place is that he doesn't want to have to worry about potential drug tests in the future. He knows hair tests can go back quite far.

[Ranke]

Yes propylhexedrine would show up in a hair test. Propylhexedrine should show up regardless of the testing method used. However if swiy fails a drug test due to propylhexedrine he can challenge the test and pay small fee to have to sent to a lab for GC/MS confirmation. The GS/MS will show up negative for amphetamine or methamphetamine and swiy will pass.

Good luck

[Lady Codone]

I disagree with the whole "take the whole cotton at once" thing. Propylhexedrine was once prescribed as a diet aid, and only in doses of 25 mg! Considering that one inhaler contains 250 mg., it doesn't seem too wise to suggest that it won't hurt anyone. People have different reactions to different drugs, unknown health conditions that randomly surface, not to mention the inhalers themselves seem to vary in potency from one to the next, so my suggestion is to take absolutely no more than HALF an inhaler cotton, but even that is pushing it for a first-timer.

I also don't understand the logic behind eating the cotton when the active ingredient can be quickly, easily and effectively extracted by soaking the cotton in lemon juice/hot water. It takes no more than 30 minutes, but you can also soak it overnight while drinking it at the same time...not exactly labor-intensive. What's the point of eating cotton anyway? Even if it doesn't cause blockages, it greatly increases discomfort (indigestion, heartburn, "lavender burps", stomach pain) for many people. Most who have tried it both ways prefer the soaking method.

Not trying to be preachy/critical here, but propyl is one of the few easily obtained, legal highs out there that works, so harm reduction is a must if it's to stay legal. We don't need anyone dying or publicly denouncing it because they failed to do everything they could to reduce the risks, which are still not fully understood with this drug.

SAFE DOSING!!

Reputation Comments on this post:

	some great harm reduction here
	Good post; this and others lately have been well-informed and helpful

[Hollow Hippie]

Originally Posted by Lady Codone

I also don't understand the logic behind eating the cotton when the active ingredient can be quickly, easily and effectively extracted by soaking the cotton in lemon juice/hot water. It takes no more than 30 minutes, but you can also soak it overnight while drinking it at the same time...not exactly labor-intensive. What's the point of eating cotton anyway? Even if it doesn't cause blockages, it greatly increases discomfort (indigestion, heartburn, "lavender burps", stomach pain) for many people. Most who have tried it both ways prefer the soaking method.

First, hot water would not work as the PPX is in a freebase form. Second many people do not try extractions because they are time consuming and/or provide low yields. Also placing a cotton rod in a capsule and swallowing is quite easy and personally SWIM has found no discomfort that is different from any other amphetamine present.

[guntroll]

SWIM have access to a lemon bush, but would rather not take the time to press them. Would putting it and squeezing contents out after soaking in Coca Cola have a similar effect?