5-MeO-MIPT report & 5-MeO-DMT synergistic potentiation

[baudmax]

My research associate, Dr. Delver, has reported the following results from his ongoing experiments conducted in a research clinic located in a small African nation which shall go unamed:

Test Subject "X"
222 lbs. (100.9 kg) body mass
~8 mg 5-MeO-MIPT hcl (1mg/ml distilled h20 soln);

9am 32oz coffee + prilosec + small piece of coffeecake
--
11:10 am * (T=0:00) Bitter taste

11:20 (T+0:10) feeling some as yet subtle energetic rising, like a slight dizziness, barely perceptible

11:35 (T+0:25) definitely noticing it, it is more there but not overpowering or anything. Feeling buzzy - bouncy energetic, easy to bounce along to music which sounds better than usual, definitely feeling turned on erotically

11:40 (T+0:30) feeling a little warm, familiar scent of tryptamine 'sweat'

11:50 (T+0:40) feeling warm, somewhat sweaty, sensing mental trippiness now nothing visual, cooling and a chill

12:00 (T+0:50) amorphous comfy head trip feeling very fluid and sexy

12:10 (T+1:00) more in the head, more mental depth coming yet to this trip, very familiar place, as-like 5-meo-dmt but slowed and stretched

12:20 (T+1:10) amazing orgasm on this stuff once push comes to shove tho no strong impetus to completion, another spontaneous wave of heat and sweat rising

12:25 music is amazing
12:32 bowl couple of hits o' weed
12:39 " seemed to 'dopey it up' a little bit, feel a little foggy at first
12:45 MIPT-THC seem to be settling into each other feels nice head trippyness growing, I feel good and at ease, extremely relaxed
12:54 music very cool atom smasher

1:10 pm (T+2:00) mellow... slow subsidence
1:44 pm (T+2:34) slight sprinkle of 5-meo-dmt mint (~1-2mg) good shot of zing body energy there, feeling of exhuberance
1:55 trip getting heavy
2:05 rapidly tapering back
2:15 pm (T+3:05) a touch mo' 5md-mint (~3-4mg)
2:28 about back to pre 2:15, kindof
2:45 pm (T+3:35) mellow subtle trippy; ate a triple fudge brownie and piece of coffee cake, with a large glass of water; taste exquisite, enhanced nicely as previously reported by others
3:15 feeling frazzled/toasty
3:30 hypervigilance, slightly wired feeling
4:17 pm (T+5:07) still buzzin' mildly
4:53 pm hit or so of weed
5:26 pm (T+6:16) slight buzz
7:10 pm (T:8:00) back down to baseline, very tired

--
Subject X reported overall effects to be threshold psychedelic at their height, Dr. Delver is considering future experiments targeting ~12mg for a dose response comparison.

*5-meo-dmt mint, 200mg/1g (20% active by weight), preparation previously described elsewhere in another post.

Dr. Delver reported that subject X followed up on the above experiment approximately 27 hours later, with an administration of ~10mg 5-MeO-DMT smoked, and commented upon a very noticeable potentiation over what test subject described as "normally expected" response to standardized ~10mg dosage 5-MeO-D, in the sense that every aspect of the experience was at least double normal duration, and intensity was increased over normal, although there was a slight headache (unusual for subject X), and reportedly increased "mental fogginess" especially in the comedown. Seems that recent 5-MeO-MIPT administration potentiated sensitivity to 5-MeO-DMT 27 hours later.

End report by Dr. Delver
--

Peace & Divinity
Baudeaux Machs

[Broshious]

Something SWIM noticed with Meo is very fast tolerance. SWIM was also using some Methylone at the time so he's sure that contributed but there was very little change in the effects of Methylone. SWIM only got really substantial effects from Meo twice.

His first time he took 2.5mg and then another 5mg dose and then was dumb enough to drive. That was the weirdest drive ever. Cars seemed like they were moving wrong but he couldn't describe exactly how sort of like they were too fluid or something. Anyways the good part was for some reason my car sounded like one being(words are so inadequate to describe drug experiences it's frustrating you always read things and say huh? And then when you feel that same thing ro something very similar you go OH that's what he meant). By that SWIM means that all the seperate sounds really came together and it felt as if it were all from the same source and individual parts were hard to distinguish. And SWIM has an extremely loud muffler(from his ricer days) and he couldn't really hear it atall. Music did sound pretty good. SWIM got to his friends apartment and SWIM was not very chatty at all. Very little euphoria other than random uncontrollable grins when SWIM didn't necessarily feel happy SWIM just couldn't control it. Again when SWIM got in her car it felt like all the sound was one unit. Went to Wegmans and SWIM was a little out of it and grinning like an idiot occassionally but unlike MDMA which it has been compared to he was self-conscious about it.

SWIM cannot see how 5-Meo is at all like MDMA(SWIM hasn't taken MDMA but Methylone seems a pretty good approximation). Very little empathic or entheogenic effects. Just a kinda of neat mood lifting trip. After that he took it a few times at 5-10mg and got really nothing. Slight speediness and mood lift but nothing really special.

Then one night SWIM decided to take 10mg and then for some reason another 10 awhile later and then 5mg more and then 5mg all about in an hour and a half to two hours or so. For awhile things were fine SWIM was hyper focused on this web comic and went through like 300 of them and couldn't stop. Then he went and laid down and he had a very severe body load comparable to being really hungover. That's when things got really weird he really wasn't feeling good and then he felt like he was going a bit crazy and he kept running his hands through his hair thinking OH SHIT OH SHIT OH SHIT.

It's really hard to describe especially since this was the first psychedelic substance SWIM had taken. He had some clear thoughts and he kinda felt that he was more in touch with his unconscious at some level or something like that. He felt that he would be more susceptible to changing bad patterns that he had seen but the feelings had kept returning despite his previous efforts. If this proved true or not is too hard to tell. Occassionally SWIM would get up and walk around and after he left the room he felt altered but much more normal. He called someone and could talk to them just fine but when he went back to his room he felt as if he were entering some other world which wasn't necessarily a bad place just a very strange feeling to be having.

At the time SWIM felt that it was a really bad idea but on further reflection it wasn't really that bad except for the stupid body load and was actually kinda cool. SWIM passed out while still very much in the experience much to his surprise. Next day SWIM felt just dandy and that was that.

[baudmax]

Originally Posted by Broshious

Something SWIM noticed with Meo is very fast tolerance. SWIM was also using some Methylone at the time so he's sure that contributed but there was very little change in the effects of Methylone. SWIM only got really substantial effects from Meo twice.

His first time he took 2.5mg and then another 5mg dose and then was dumb enough to drive. That was the weirdest drive ever. Cars seemed like they were moving wrong but he couldn't describe exactly how sort of like they were too fluid or something. Anyways the good part was for some reason my car sounded like one being(words are so inadequate to describe drug experiences it's frustrating you always read things and say huh? And then when you feel that same thing ro something very similar you go OH that's what he meant). By that SWIM means that all the seperate sounds really came together and it felt as if it were all from the same source and individual parts were hard to distinguish. And SWIM has an extremely loud muffler(from his ricer days) and he couldn't really hear it atall. Music did sound pretty good. SWIM got to his friends apartment and SWIM was not very chatty at all. Very little euphoria other than random uncontrollable grins when SWIM didn't necessarily feel happy SWIM just couldn't control it. Again when SWIM got in her car it felt like all the sound was one unit. Went to Wegmans and SWIM was a little out of it and grinning like an idiot occassionally but unlike MDMA which it has been compared to he was self-conscious about it.

SWIM cannot see how 5-Meo is at all like MDMA(SWIM hasn't taken MDMA but Methylone seems a pretty good approximation). Very little empathic or entheogenic effects. Just a kinda of neat mood lifting trip. After that he took it a few times at 5-10mg and got really nothing. Slight speediness and mood lift but nothing really special.

Then one night SWIM decided to take 10mg and then for some reason another 10 awhile later and then 5mg more and then 5mg all about in an hour and a half to two hours or so. For awhile things were fine SWIM was hyper focused on this web comic and went through like 300 of them and couldn't stop. Then he went and laid down and he had a very severe body load comparable to being really hungover. That's when things got really weird he really wasn't feeling good and then he felt like he was going a bit crazy and he kept running his hands through his hair thinking OH SHIT OH SHIT OH SHIT.

It's really hard to describe especially since this was the first psychedelic substance SWIM had taken. He had some clear thoughts and he kinda felt that he was more in touch with his unconscious at some level or something like that. He felt that he would be more susceptible to changing bad patterns that he had seen but the feelings had kept returning despite his previous efforts. If this proved true or not is too hard to tell. Occassionally SWIM would get up and walk around and after he left the room he felt altered but much more normal. He called someone and could talk to them just fine but when he went back to his room he felt as if he were entering some other world which wasn't necessarily a bad place just a very strange feeling to be having.

At the time SWIM felt that it was a really bad idea but on further reflection it wasn't really that bad except for the stupid body load and was actually kinda cool. SWIM passed out while still very much in the experience much to his surprise. Next day SWIM felt just dandy and that was that.

Total combined dose of 30mg sounds heavy, though a lot of that was bumped on after the fact, so hard to tell what that is really equivalent to. Subject X had reported 'very strong' urge to bump original 8mg dose, about 1.5-2 hrs in (but didn't). Dr. D'Elver reported that Subject X has been subjected to further experiments, with the following brief notes:

Subjext X, 12mg (first instance): More substantial than 8 mg, for sure, especially on the coming up into the peak, definitely a bit of a "woah, yeah!"; Extremely erotic

Subject X, 12mg (2nd instance): A week following first instance of 12mg, effects much more subdued, tho Subject X was noted to be experiencing abnormally high prolactin levels. Apparently elevated prolactin can cause reduction of dopaminergic/serotonergic effects, which is what Dr. D'Elver is guessing; Oddly, very subdued, more head-trippy and very little erotic quality to this session. Subject X also reported unusual tolerance to standardized 10mg administrations of 5-MeO-DMT within the days preceding this experiment, and mentioned that "usually 10mg effects me pretty good on the first administration, the last couple of days it just hasn't been the same as usual".

Subject X, 14mg: 1 week following 2nd 12mg instance. Subject X's prolactin levels were reduced considerably over prior experimentation, and the additional 2mgs definitely gave the headtrip greater "depth" and duration, although the coming up to peak didn't seem paricularly intense (perhaps subject becoming acclimatized/normalized to this 'state'). Subject X was still feeling rather affected at 6 hours, but had no trouble at all going to sleep.

Dr. D'Elver has expressed the same concerns re: rapid tolerance, esp. with the MIPT. D'Elver will send me further results, as they become available.

Peace and Divinity
Baudeaux Machs