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Various drugs not covered by other forums Discussion of Psychoactive drugs that do not have a specific forum

 
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  #1  
Old 22-03-2007, 20:44
deekyleeky deekyleeky is offline
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Ropinirole? Just wondering if this new drug has any recreational value.

The drug is called requip or ropinirole. A friend of swim acquired some of these pills and is wondering if they have any recreational value. Here is a short description of the drug.

Mechanism of Action: REQUIP is a non-ergoline dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.
Ropinirole has moderate in vitro affinity for opioid receptors. Ropinirole and its metabolites have negligible in vitro affinity for dopamine D1, 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, alpha1-, alpha2-, and beta-adrenoreceptors.

What does all this mean? I saw alot of familiar drug groups in there.

Thanks

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  #2  
Old 22-03-2007, 21:49
Nagognog2 Nagognog2 is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

It means it's action is dissimilar to such as valium or other common sedatives. It is being touted as a safe, non-addictive sleeping pill that can be used indefinitely with no problems at all...

Until they find dreadful problems with it next year after everyone gtrows an extra sex-organ on their chin and develops brain-cancer.
  #3  
Old 22-03-2007, 22:07
deekyleeky deekyleeky is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Well thanks for clarifying this, swim thanks you. However I dont think it is being advertised as a sleeping pill. It is for "restless leg syndrome" and/or parkinsons disease. But that is neither here nor there, you answered my question and therefore I have concluded this drug has no recreational value at all. Thanks again
  #4  
Old 22-03-2007, 22:11
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Re: New downer? Just wondering if this new drug has any recreational value.

Restless leg syndrome is a sleep disorder.
  #5  
Old 23-03-2007, 04:45
deekyleeky deekyleeky is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

thanks for that. I know i sound stupid, but swim is a newbie. swim is not a newbie in the sense that he is not an experienced drug user. Swim is very experienced. Swims only question was if this had recreational value, not if the pill was a sleeping pill. Thanks for the input anyways
  #6  
Old 23-03-2007, 05:34
Nagognog2 Nagognog2 is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

It's too new for many reports regards it's abuse-potential, but the drug company would likely keep such quiet if possible. They're spending millions on TV ads. If a monkey were to find out, give it a banana to write a report.
  #7  
Old 23-03-2007, 05:37
Nicaine Nicaine is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Dopamine agonists do have potential recreational uses (and it also has opiate receptor affinity, very interesting), but until someone experiments it's only a theory. If it's unscheduled, chances are whatever recreational value it has will not be terribly high.
  #8  
Old 23-03-2007, 06:24
snapper Gold member snapper is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Probably like L-dopa or wellbutrin.
  #9  
Old 23-03-2007, 14:14
Jatelka Jatelka is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Mmmmm... Acute dystonia.
  #10  
Old 23-03-2007, 18:23
Alicia Gold member Alicia is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Quote:
Originally Posted by Jatelka View Post
Mmmmm... Acute dystonia.
^^
Swia being the curious peep that she was had a look 4 info on it out of curiosity and found this. and came across Benztropine, which she reading about.

http://www.cmdg.org/Movement_/drug/acute2/acute2.htm

Quote:
Acute Dystonic Reactions

Clinical

An acute dystonic reaction consists of sustained, often painful muscular spasms, producing twisting abnormal postures. 50% occur within 48 hours of initiation of the neuroleptic. 90% occur within 5* days. These reactions are more common with parental then oral medications. They're more common in the younger patients, and more common in males than females in the young age group.

Approximately 3 to 10% of patients exposed to neuroleptics will experience an acute dystonic reaction. Haldol and the long acting. injected fluphenazines have the highest incidence of these reactions.* The risk is higher in patients with a prior history of a similar reaction or a family history of dystonia. The order of the most frequent types include neck dystonia 30%, tongue dystonia 17%, jaw dystonia 15%,* oculorgyric crisis (eyes rolling back, and neck arching) 6%, and opisthotonus (body arching) 3.5%. The movements than may fluctuate over hours and temporarily abate in response to reassurance. This can* cause an inappropriate diagnosis of hysteria. They typically last minutes to hours without treatment. Occasionally the movements are more choreiform. They are more typically generalized in young patients* and more focal in the older patients.

Pathophysiology

The pathophysiology of acute dystonic reaction secondary to* neuroleptics remains unknown. The movements typically occur at a time when the blood level of medication is dropping.* Patients with liver dysfunction are more prone to these reactions. There is a higher* incidence in patients with a prior history of a similar reaction or family history of dystonia.

Treatment

The treatment is to discontinue the offending agent. Intr-muscular anticholinergics (e.g. Benztropine 2 mg IV) should be used and should be continued orally for 24 - 48 hours depending on the ˝ life of the* neuroleptic used. If the neuroleptic treatment is to be continued, usually the anticholinergic can be safely tapered over 2 - 3 weeks. Some evidence suggests that long-term concomitant anticholinergics may* predispose to tardive dyskinesia.

Amantadine is a preferred treatment option by some due to a better side effect profile. Routine prophylaxis with these medications would* be appropriate in patients with a previous proven risk for dystonic reactions.
  #11  
Old 23-03-2007, 19:18
Zaprenz Zaprenz is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

I always found it amusing methylphenidate has "may cause drowsiness" as a warning label.

Having never tried it I always assumed it was stimulating( Da Reuptake I). Anyone know if it is certain Dopamine receptors which (can) cause drowsiness or a general affect that sometimes occurs with Dopaminergics?

Certain nootropics which affect dopamine caused drowsiness in SWIM.
  #12  
Old 23-03-2007, 22:15
Psych0nautPlatinum member Psych0naut is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Quote:
Originally Posted by Zaprenz View Post
I always found it amusing methylphenidate has "may cause drowsiness" as a warning label.

Having never tried it I always assumed it was stimulating( Da Reuptake I). Anyone know if it is certain Dopamine receptors which (can) cause drowsiness or a general affect that sometimes occurs with Dopaminergics?

Certain nootropics which affect dopamine caused drowsiness in SWIM.
SWIMs boxes of methylphenidate always caried a label saying:"Do not partake in traffic, may slow down reaction" Yeah right, an upper slows down your reaction time
  #13  
Old 24-03-2007, 01:38
Nagognog2 Nagognog2 is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Ritalin and amphetamines are SUPPOSED to make people with ADD & ADHD calm and mellow. "Normal" people are the ones it gives a boost in energy levels to. Kid I knew was given Seconal to wake him up, and Ritalin to knock him out in school. Instead it just fucked him up so badly that he never learned how to read or write. When his mother complained to the school-board, they threatened to have the kid committed to a state mental hospital if she didn't shut up about their utter failure.
  #14  
Old 25-03-2007, 17:42
Zaprenz Zaprenz is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Quote:
Originally Posted by Nagognog2 View Post
Ritalin and amphetamines are SUPPOSED to make people with ADD & ADHD calm and mellow. "Normal" people are the ones it gives a boost in energy levels to. Kid I knew was given Seconal to wake him up, and Ritalin to knock him out in school. Instead it just fucked him up so badly that he never learned how to read or write. When his mother complained to the school-board, they threatened to have the kid committed to a state mental hospital if she didn't shut up about their utter failure.
Do kids/adults with ADD find benzos/barbs wake them up?(in general) ^Its very sad when psychoactive drugs mess a child up.

Last edited by Zaprenz; 25-03-2007 at 18:50.
  #15  
Old 26-03-2007, 15:04
Psych0nautPlatinum member Psych0naut is offline
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Re: New downer? Just wondering if this new drug has any recreational value.

Nope, au contrair mon frair. SWIM has ADD and benzo's only make him sleepy, stimulants in small doses do make him calm though.
  #16  
Old 31-03-2007, 15:42
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Re: New downer? Just wondering if this new drug has any recreational value.

what about stimulants in large doses?
  #17  
Old 15-04-2008, 01:57
Dole654 Dole654 is offline
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Re: Ropinirole? Just wondering if this new drug has any recreational value.

hmmm... I've been looking through DA receptor subtype distinctive effects etc.

A pretty interesting link about the D3 receptor's role in cocaine abuse -
http://www.jneurosci.org/cgi/content/full/16/19/6100

Anyway, SWIM's lab rat may be testing the compound this evening, depending on his further research. If the experiment is undertaken, a full report will be posted.
  #18  
Old 27-04-2008, 09:17
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Re: Ropinirole? Just wondering if this new drug has any recreational value.

Tablet was pentagonal bipyramidal with a second smaller similar pentagon

inlaid, before coming to a dull point.Yellow in color. .5 mg dosage.




<from drugs.com/pdr>



0.00 - .5 mg ropinirole hcl insufflated (1:09)

0.01 - rapid onset

0.03 - continuing to come up

0.05 - distinct calmness, opiate-like worthlessness

0.10 - slight trails; limbs feel heavy; strongly enhanced after images

0.15 - visual static; high gravity

0.30 - subject passes out


Interesting to say the least... Baboon could only feel his core beginning from the abdomen up.
Not necessarily in a good way, however. At times, Baboon indicated that it felt like his limbs had completely disappeared.

Interesting. Baboon isn't sure whether or not he enjoyed it. Definitely merits more testing, however.

Baboon just now upon me finding the above picture realized it was prescribed in quite a higher dose than he had thought. .5 mg insufflated had a pretty pronounced effect. He says he can't even imagine insufflating 3, let alone 5 mgs!


**sorry it turned out a bit short...
  #19  
Old 17-05-2008, 19:17
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Re: Ropinirole? Just wondering if this new drug has any recreational value.

Quote:
Originally Posted by deekyleeky View Post
The drug is called requip or ropinirole. A friend of swim acquired some of these pills and is wondering if they have any recreational value. Here is a short description of the drug.

Mechanism of Action: REQUIP is a non-ergoline dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4 receptor subtypes.
Ropinirole has moderate in vitro affinity for opioid receptors. Ropinirole and its metabolites have negligible in vitro affinity for dopamine D1, 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, alpha1-, alpha2-, and beta-adrenoreceptors.

What does all this mean? I saw alot of familiar drug groups in there.

Thanks
I don't give a fuck what anyone says, but that stuff is like 5 drugs in one. The main actions are dopamine and opioid agonist. It also has SOME (notice it says negligible, not none) affinity for a shitload of other receptors that get you high, including 5-HT2 (acid anyone?). Just try a few of those man.
  #20  
Old 17-07-2008, 14:13
paranoid_android paranoid_android is offline
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Re: Ropinirole? Just wondering if this new drug has any recreational value.

This drug directly affects the dopamine system. And it may trigger the opioid receptors. The real question is, considering the beauty of it on paper, is why the hell aren't people scrambling to try this thing out? Could be the sleepiness (requip doesn't affect D1 receptors, the stimulating ones) that deters people from it, or it could just be a general lack of euphoric properties.

SwiPA has ready access to these and will start trying them in oral and insufflated doses. A thread with his reports will be made as soon as the first trial is completed.

EDIT: This drug may benefit from combination with another substance that has effects on the D1 receptors. That combo also might be very bad for an unfortunate lab rat's health. There could be an alcohol/benzo type reaction here, in that small doses of both synergize nicely, but anything over the threshold dose is hazardous.

Last edited by paranoid_android; 17-07-2008 at 14:19.
  #21  
Old 27-10-2009, 16:01
Frogster Frogster is offline
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Subjective effects of Ropinirole (2 mg daily)

Swim has a prescription for Ropinirole for his Restless-Legs-Syndrome. Swim found that Ropinirole is moderately effective to that extend.

When it comes to the recreational value of ropinirole, there is none, or just a hint of it. Stragely, Swim find his mind altered whilst on Ropinirole in a way that is not dissimilar to good cocaine. Not meaning that Swiy can expect a high though. The altered state of mind consists in some strange antidepressant effect. Rather then enhacing the mood, it seems that Swims desire or passion is upped. While his mood remains unchanged, he is very confident about what he is going to do. Smell seems more intense. Swim enjoys smelling the rotting leaves that just fell from the trees now in autumn. Smoke (especially Tabac) smells nice. Swim remembers doing tasks in his childhood that gave him a similar feeling, like firing rockets on NYE or playing that brand new Videogame... Quite a lot of self-confidence is noted but due to the lack of D1-Stimulation, this isn't seen as arrogance. Swim tends to look and smile to girl strangers a lot more. Embarassment disappears completely even though Swim doesn't feel the need for exessive talking. Paying attention seems to cost Swim less effort.

This effects were subtle, but present none the less. There is definately some "cocaine-flavour" to it...

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  #22  
Old 13-12-2009, 11:06
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Re: Ropinirole? Just wondering if this new drug has any recreational value.

Anyone tried mixing methylphenidate with ropinirole? I'm cursed with ADHD and methylphenidate alone is not working for me very well. One dosage (5mg, 10mg) is effective for approximately 2h, then after next two dosages methylphenidate stops working and it doesn't matter how much I'll take next - it doesn't kill the very bad comedown. It's like after 6 hours I'm developing some kind of tolerance and I have to endure the urge to destroy the world till next day. My theory is that I have really messed up D-receptors, that's why I'm interested in ropinirole.
Anyone?
  #23  
Old 14-12-2009, 09:28
Frogster Frogster is offline
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Re: Ropinirole? Just wondering if this new drug has any recreational value.

Dopamine agonists Ropinirole can alleviate some of the symptoms of Dopamine depletion. It can, for instance help with Restless-Legs-Syndrome, which is associated with Dopamine insufficiency. Swiy could give it a try...
  #24  
Old 16-12-2009, 17:26
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Re: Subjective effects of Ropinirole (2 mg daily)

Thank You for the reply.


Quote:
Originally Posted by Frogster View Post
Swim has a prescription for Ropinirole for his Restless-Legs-Syndrome. Swim found that Ropinirole is moderately effective to that extend.

When it comes to the recreational value of ropinirole, there is none, or just a hint of it. Stragely, Swim find his mind altered whilst on Ropinirole in a way that is not dissimilar to good cocaine. Not meaning that Swiy can expect a high though. The altered state of mind consists in some strange antidepressant effect. Rather then enhacing the mood, it seems that Swims desire or passion is upped. While his mood remains unchanged, he is very confident about what he is going to do. Smell seems more intense. Swim enjoys smelling the rotting leaves that just fell from the trees now in autumn. Smoke (especially Tabac) smells nice. Swim remembers doing tasks in his childhood that gave him a similar feeling, like firing rockets on NYE or playing that brand new Videogame... Quite a lot of self-confidence is noted but due to the lack of D1-Stimulation, this isn't seen as arrogance. Swim tends to look and smile to girl strangers a lot more. Embarassment disappears completely even though Swim doesn't feel the need for exessive talking. Paying attention seems to cost Swim less effort.

This effects were subtle, but present none the less. There is definately some "cocaine-flavour" to it...
How much did Swim take? How many portions? Any side effects?
  #25  
Old 18-12-2009, 14:31
Frogster Frogster is offline
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Re: Ropinirole? Just wondering if this new drug has any recreational value.

1mg at the same time. There were no side effects noticed.

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