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#1
21-03-2007, 00:22
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MDMA, Temperature, and Neurotoxicity
SWIM just came across an interesting article posted on another forum, and after searching here and not finding it he thought he'd post it here:
From http://www.jneurosci.org/cgi/content...act/18/13/5086 Rats treated with MDMA at 20 and 22°C showed a hypothermic core temperature response. Treatment with MDMA at 28 and 30°C produced a hyperthermic response. At ambient temperatures of 20-24°C, neurotoxicity was not observed in the frontal cortex, somatosensory cortex, hippocampus, or striatum. At ambient temperatures of 26-30°C, neurotoxicity was seen and correlated with core temperature in all regions examined. These data indicate that ambient temperature has a significant affect on MDMA neurotoxicity, core temperature, and thermoregulation in rats. 
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