MDMA, Temperature, and Neurotoxicity

[Broshious]

SWIM just came across an interesting article posted on another forum, and after searching here and not finding it he thought he'd post it here:

From http://www.jneurosci.org/cgi/content...act/18/13/5086

Rats treated with MDMA at 20 and 22°C showed a hypothermic core temperature response. Treatment with MDMA at 28 and 30°C produced a hyperthermic response. At ambient temperatures of 20-24°C, neurotoxicity was not observed in the frontal cortex, somatosensory cortex, hippocampus, or striatum. At ambient temperatures of 26-30°C, neurotoxicity was seen and correlated with core temperature in all regions examined. These data indicate that ambient temperature has a significant affect on MDMA neurotoxicity, core temperature, and thermoregulation in rats.

Reputation Comments on this post:

thanks

[red_LED]

I am not quite a scientist, so does neurotoxicity mean damaging to the brain, or.... a much better MDMA high?

[fnord]

is there a diffence?just kidding.but i think i read somewhere that scopolamine prevents damage to mylar in dxm pcp and *possibly* mdma users

[WrtngCocaineTutorial]

Originally Posted by red_LED

I am not quite a scientist, so does neurotoxicity mean damaging to the brain, or.... a much better MDMA high?

hehe, no SWIY won't get a better high when the neurotoxicity is high

[Expat98]

I just ran across another study linking neural damage from MDMA to high ambient temperatures.

From http://www.sciencedaily.com/releases...0803092825.htm

Source: Basque Research
Date: August 7, 2007

Neural Damage Provoked By Ecstasy Is Related To Ambient Temperature At Which It Is Consumed

Science Daily — There exists a direct relationship between the consumption of MDMA, or Ecstasy, at a high ambient temperature and an increase in the neural damage which this drug provokes. This was the conclusion of the research carried out by Beatriz Goñi at the School of Pharmacy of the University of Navarra.

These results form part of her doctoral dissertation, entitled “A Study of the Neurotoxicity Mechanism of 3.4-methylenedioxy-N-methylamphetamine (MDMA or ‘Ecstasy’) after its Administration in Rats: New Responses to Old Questions.”

By means of this study, the researcher was able to relate for the first time the body temperature of the user with a higher metabolism of this substance. There are two factors which, when they co-occurcan produce malignant hyperthermia, a disorder which can sometimes be fatal.

In order to come to this conclusion, the Pamplonan pharmaceutical specialist administered the drug to rats at ambient temperatures of 15, 21 and 30 degrees centigrade. After performing the pertinent analyses, she demonstrated that metabolism of Ecstasy is accelerated by higher ambient temperatures at the time of administration. In addition, higher ambient temperatures also increase, in the same proportion, the neurochemical deficit that affects the brains of the users of this drug.

Higher Risk in Closed Establishments

According to Beatriz Goñi, the author of the study undertaken at the University of Navarra, the discoveries of this research project acquire more relevance precisely because Ecstasy is typically taken in closed environments, with lots of people and poor ventilation, due to which factors the temperature tends to be quite high.

According to Beatriz Goñi, the author of the study undertaken at the University of Navarra, the discoveries of this research project acquire more relevance precisely because Ecstasy is typically taken in closed environments, with lots of people and poor ventilation, due to which factors the temperature tends to be quite high.

In addition, she notes that the neural damage provoked by this substance, and which originally was only observed in rats, has already been demonstrated in humans, who appear to suffer severe damage to the serotoninergenic neurons, which are involved in processes as basic as sleep, appetite and mood regulation.

Finally, the pharmaceutical specialist noted that the damage caused by the consumption of MDMA is dependent upon its being metabolized after to its ingestion, since if it were administered directly to the brain, neuronal damage would not occur.

Note: This story has been adapted from a news release issued by Basque Research.

[VitaminK22]

Why dont they test this on humans instead of rats, swim would b more than happy to get paid for takin drugs

[fnord]

state/federal laws

[sterling77]

Another reason to stay hydrated while rolling aside from regular dehydration.

[epote]

possibly mdma acts synergisticaly/inhibitory at the hypothalamus then?

what do we know about mdma and neuroendocrinology actually? im not to familiar

[Jatelka]

@ Broshius: Please upload the full pdf to the file archive under "MDMA"

[Broshious]

Done and done.

[MrMinty]

In terms of a relationship between the high and temperature, has SWIY ever had a cold blast of air bring them crashing down, only to join the thick of the dancefloor again, get very hot and come rushing back up? Happens to SWIM a lot - the heat seems to help come back up.