Is sustainable drug-use possible? (i.e. daily non-stop)

[noHope]

Virtually every addictive drug has been shown to increase dopamine in the presynatic gap, including most of the drugs mentioned in this site.

The problem with doing drugs daily is then that the dopamine receptors are down-regulated in those pleasure-pathways affected by the drug. This is otherwise known as tolerance and is probably the main reason druggies stop (either their dosage requires too much money or they OD).

In the absence of the drug (or a dopamine antagonist), dopamine receptors could come back. This means withdrawal.

The question I'm asking is if this cycle addiction/withdrawal is avoidable?

I'm thinking that perhaps you could cycle your dopamine agonists (opiates, cocaine, amphetamines), with other psychoactives that have much more mild dopaminergic effects, (i.e. benzos, LSD, dissociatives, THC). Thus avoiding the buildup of tolerance.

Tolerance means either less noticable effects (no longer getting high), or the need to increase dosage, at the expense of health and money. By cycling, in theory, this might be avoidable, as well as withdrawal (one will be feeling the effects of another drug during withdrawal).


Anyway, just a thought/dream, please tell me what you think.

[xctico]

Well I for once take antidepressants every single day [as prescribed by my doctor], that qualifies as taking drugs daily doesn't it?

I know as a fact that Q likes to smoke weed on a daily basis, and barelly ever goes a day by without he smoking a fatty... as for tobacco users the hard thing is finding one that goes by an hour without smoking...

Now if you mean taking a drug like it was oxygen on a permanent basis with every single breath... well... how do you know you're not already doing it? [oxygen is a drug. ]

[stoneinfocus]

Of course it works.

Cycling drugs to avoid serious side effects and receptor downregulation, or withdrawl, is common medical praxis or at least should be,
where I live no one of the doc´s is working anymore, they just sell their hours best to the insurances and pharmas and don´t give a shit.

Swim never really experienced a tolerance to any drug, besides of nicotine and cannabis, which he stopped both taking.

Amphetmanines work fine, opiates now-and-then, he developesd tolerance to corticosteroids, though, but he had to take them for his copd.

Swim was never forced by a drug to take a dose that´d been too high or would have let him got into a seriuos addiction or withdrawl, not even the so-said most addictive illegal once, it was more like the complete opposite to swim.