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  #1  
Old 13-02-2007, 17:16
Ellis D. Ellis D. is offline
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Grapefruit juice potentation with methadone

Hello,

SWIM's wondering how effective grapefruit juice is for potentating methadone...say 5mg...?


~Thanks
  #2  
Old 13-02-2007, 19:52
Orchid_Suspiria Orchid_Suspiria is offline
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Re: Grapefruit juice potentation with methadone

SWIM discovered just two days ago that grapefruit juice does indeed potentate methadone.A good technique is dissolving the methadone in the grapefruit juice and then drinking it and then following it with more grapefruit juice SWIM found out.Not only does it potentate the methadone it makes the effects come on more rapidly.
  #3  
Old 14-02-2007, 06:10
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Re: Grapefruit juice potentation with methadone

Grapefruit juice will potentiate pretty much any opiate with the exception of codeine. SWIM has tried this, drinking the juice 45 minutes before taking the methadone. The methadone still took a couple hours to set in, but the peak did seem longer than usual, about 3 hours or so for SWIM. SWIY is wise to start with 5 mg, be careful about re-dosing though because many people think that the methadone isnt working, when it hasnt kicked in yet, and end up ODing.
  #4  
Old 15-02-2007, 03:14
BANGINCOLOR BANGINCOLOR is offline
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Re: Grapefruit juice potentation with methadone

What effects of methadone??? There are no effects, especially 5mg of it!!! It takes days to build up in your system before it even starts to work. That's why peopel OD on it, they take it and expect oxycodone type results which they will never get. So they take more and more and respitory depression is a heavy side effect with methadone.

Now that docs are allowed to prescribe methadone for pain more openly/legally, I feel we will see amounts like 1mg, .5mg.

SWIM has taken both oxy products and methadone and I must say, if SWIM didn't love oxy so much, SWIM would definitely be on meth for the DDD he has.

No cravings, excellent pain relief. A lot of times SWIM would miss his dose of meth cause it was working so good. Gotta wait 3 days for it to be at it's peak effectiveness. With the oxy, it's up down and a few hours after your dose starts to wear off, you're lookin at the clock countin the hours for the next dose. Not like that at all with methadone.

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everyone is different, & it IS possible to get a euphoric high from methadone, so stop saying you can't as though it were an undisputable medical fact!
  #5  
Old 16-02-2007, 02:20
Ellis D. Ellis D. is offline
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Re: Grapefruit juice potentation with methadone

Thanks agian.

Now anyone know if orange juice has similar effects as grapefruit juice with potentating opiates? The other day SWIM took 5mg of methadone and could have sworn that drinking a glass of orange juice made it more euphoric...placebo maybe..
  #6  
Old 16-02-2007, 03:46
BANGINCOLOR BANGINCOLOR is offline
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Re: Grapefruit juice potentation with methadone

Quote:
Originally Posted by Ellis D. View Post
Thanks agian.

Now anyone know if orange juice has similar effects as grapefruit juice with potentating opiates? The other day SWIM took 5mg of methadone and could have sworn that drinking a glass of orange juice made it more euphoric...placebo maybe..
I think your whole situation is based on the "placebo effect" cause, and you can Google this info yourself, Methadone does not produce any euphoria. It just keeps addicts from getting sick which is what they get addicted to.

It takes DAYS for a patient to feel the effects of methadone. Poppin a 5mg methadone will do NOTHING, you'll feel NOTHING!!

btw......it's only Grapefruit juice and a certain kind of Grapefruit juice that potentiates only certain opiates. Does nothing for others. If you THINK you felt something extra cause you drank some orange juice, you certainly are on a planet all your own!
  #7  
Old 16-02-2007, 17:33
Ellis D. Ellis D. is offline
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Re: Grapefruit juice potentation with methadone

BANGINGCOLOR..... maybe you shouldn't reply to threads that you don't understand/can't relate to.

Thanks again for the advice, SWIM is almost done with opiates after 5 years of rollercoastering.
  #8  
Old 16-02-2007, 17:36
Ellis D. Ellis D. is offline
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Re: Grapefruit juice potentation with methadone

Can't edit my post sense I'm such a rebel but I forgot to add; yesterday SWIM picked up some Kroger brand 100% grapefruit juice extract. Will this work for potentating opiates?
  #9  
Old 16-02-2007, 19:22
Son of Axeman Son of Axeman is offline
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Re: Grapefruit juice potentation with methadone

If there is a certain type of grapefruit juice used to potentiate opiates, it should be posted in this thread, SWIMethinks. Even if it's found elsewhere on the forum, this IS a potentiation thread, regarding grapefruit juice specifically, so it should be posted.

Otherise, a surefire method of getting pure grapefruit juice is to buy a juicer and throw a grapefruit up in there. That would work rather nicely, SWIMethinks.
  #10  
Old 18-02-2007, 00:52
~lostgurl~ ~lostgurl~ is offline
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Re: Grapefruit juice potentation with methadone

Would this work if a person injected the methadone, or does it only work when taken orally?
  #11  
Old 18-02-2007, 00:54
Orchid_Suspiria Orchid_Suspiria is offline
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Re: Grapefruit juice potentation with methadone

It's pretty pointless to inject methadone,for one methadone just isn't designed for that and methadones oral bioavailabillity pretty much takes away the need for injecting.As to if that would work if someone injected methadone I'm not so certain.
  #12  
Old 18-02-2007, 01:09
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Re: Grapefruit juice potentation with methadone

SWIM has a friend who injects methadone on a regular basis and he does it because he likes the rush, apart from the rush he said the buzz is pretty much the same as when taken orally but it doesn't last as long.
  #13  
Old 18-02-2007, 02:10
Son of Axeman Son of Axeman is offline
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Re: Grapefruit juice potentation with methadone

IVing a substance bypasses first-pass metabolism in teh liver. Since the grapefruit juice method works by inhibiting a particular liver enzyme (I forget which one), it's useless when IVing, as the substance goes straight into the bloodstream.
  #14  
Old 18-02-2007, 02:17
Orchid_Suspiria Orchid_Suspiria is offline
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Re: Grapefruit juice potentation with methadone

By injecting methadone are we talking about methadone syrup as in the kind seen in clinics or as in methadone tablets,most likely methadose?SWIM really can't see going through the trouble to inject methadose especially the orange flavored ones.
  #15  
Old 20-02-2007, 06:18
Son of Axeman Son of Axeman is offline
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Re: Grapefruit juice potentation with methadone

Still waiting on that grapefruit juice question.

...Jus' sayin'...
  #16  
Old 01-04-2007, 17:24
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Re: Grapefruit juice potentation with methadone

well first of all bangincolor swim would have to disagree, cause all of swims friends in highschool who take methadone, all pop a quarter of a 40mg tab and are fukd up all night (some even take half) and swim knows from personal experience he gets definate euphoria.

but anyways swim was wondering if he had 3/4 of a 40 mg pill and was planning on taken it over the next 3-4 days would there be any problems with it building up in swims system? swim has small opiate tolerance.
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Old 01-04-2007, 17:33
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Re: Grapefruit juice potentation with methadone

well swim found this http://www.drugs-forum.com/forum/sho...ight=methadone and thinks after taking 10mg the first day only 5 the next?
  #18  
Old 25-01-2009, 18:04
baron samedi baron samedi is offline
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Re: Grapefruit juice potentation with methadone

Regarding GFJ potentiation of methadone SWIM has been taking it roughly 30-45 minutes before he takes the meth. Hard for him to say if it really increases the effects or not. He should try it without some days.
Is his method likely to be most effective or could he enhance it further by taking some after he's taken the meth as well?
  #19  
Old 04-02-2009, 20:54
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Re: Grapefruit juice potentation with methadone

From SWIM's experience 100% unsweetened pure GFJ DOES potentiate certin opiates and will do so for Methadone.GFJ effects liver enzymes that help process certin opiates therefor allowing a good amount to go by.SWIM has also felt W/D's due to NOT drinking GFJ with his daily meds which he does every day with good results.
  #20  
Old 05-02-2009, 19:13
baron samedi baron samedi is offline
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Re: Grapefruit juice potentation with methadone

SWIM read somewhere that it is advised to take GFJ about 4 hours before you take your meds, as the effect of GFJ lasts a long time.
Does SWIMekone take the GFJ at the same time as his meds? SWIM would have difficulty doing this as he takes his meth under supervision.
  #21  
Old 05-02-2009, 21:21
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Re: Grapefruit juice potentation with methadone

SWIM usually starts to drink GFJ about an hour before doseing and then continues to drink it for awhile after.SWIM likes GFJ so he drinks it as much as one would drink water.Remember 100% pure GFJ not that sweetened/watered down crap is SWIM choice of beverage.
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Old 28-02-2009, 17:45
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Re: Grapefruit juice potentation with methadone

A couple of points SWIM had about GFJ and methadone. He has been told that the GFJ to be used with methadone/opiates in general is white GFJ, rather than pink GFJ. This is surprising to SWIM, as he has almost always used pink GFJ when trying to potentiate opiates. If it is the case that white GFJ is the right one to use, can anyone explain WHY? What's the difference? He's also heard differing reports as to whether fresh GFJ or the long-life stuff made from concentrate is the best to use. Again, anyone have any scientific/anecdotal evidence to submit?
Cheers, Baron

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Interesting info and good questions.
  #23  
Old 02-09-2010, 17:49
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Re: Grapefruit juice potentation with methadone

The best grapefruit juice to take to potentiate any opioid (including methadone) is

frozen white grapefruit juice concentrate

Apparently, the chemical in white grapefruits that does the inhibiting is found more concentrated in the pith & skin. When they are making the concentrate, they squish it all up, and more of the oil that's found in the skin makes it into the concentrate version than in the straight up juice version. (I read this somewhere else on the Forum...perhaps in that monsterous potentiation thread?)

Also, many 'premade' grapefruit juices available have very little ACTUAL grapefruit juice in them, even when it reads '100% Juice', since most of the '100% juice' is made up with white grape & apple juices (as sweeteners & bulking agents). Using the frozen concentrate bypasses these issues.

Often, Girlie would spoon out a tablespoon or two of FWGJC (Frozen White Grapefruit Juice Concentrate) into a small glass & pour over it just enough pineapple juice to melt/stir it into. Then she'd gulp it down in as few glugs as possible (she doesn't like grapefruit juice). Then, one can proceed as desired.

~Kailey

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Very good post with some really interesting information.
  #24  
Old 13-02-2011, 23:43
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Re: Grapefruit juice potentation with methadone

what about consuming about 2 tea spoon fulls of baking soda, half hour before and after consuming oral liquid methadone 45mg.
would that have any greater impact on the methadone? if so, how!?!?!? thanks!
  #25  
Old 28-06-2011, 03:32
Gledwood Gledwood is offline
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Re: Grapefruit juice potentation with methadone

Some of you seem to be confusing the effects methadone has on the "opiate naive" individual and the addict with a long term opiate habit. To a longterm heroin user 5mg methadone would be a tiny dose, but somebody without a habit might well feel 5mg. Before swim got addicted to heroin swim used to drink 30mg methadone and get pretty severely intoxicated. And yes, euphoria was involved. Anyone considering trying methadone for kicks should take extreme care: Swim knows somebody who took 5mg in order to fake up a urine test. He reacted so badly he was lucky not to have been carted off in an ambulance. So be careful! There was a well documented case in Britain about 10 years ago where some guy pretended to have a habit and got himself scripted at an NHS clinic. 3 days later he was found dead on just 40mg. Methadone is a peculiar drug. You have been warned!

Swim is considering purchasing some grapefruit juice before knocking back swim's disgustingly high methadone dose tomorrow....

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