Combinations - GHB and RITALIN (methyphenidate)

[supremedan]

Swim would like to know if any SWIM tried this combination . Swim wants to use a higher dose of GHB with out getting sleep.SWIM would like to know if by any chance ritalin will kill some of GHB euphoric properties or enhance it.

PEACE!!

[MrG]

SWIM has reported on GHB and Coke

http://www.drugs-forum.com/forum/showthread.php?t=26854

But he doesn't see why a straightforward amphetamine based buzz wouldn't be worth experimenting with either. His only concern, as he mentioned in his report, is that should SWIY consume enough stimulant to overcome the urge to sleep, SWIY could end up mentally switched off yet physically active beyond that which SWIY is able to remain safe. SWIM's wife has a tendency to let herself switch off and go with the flow, so to speak, but he sometimes has to straighten his head up so he can ensure she doesn't go off on a bit of a tangent.

SWIY should post a report on his findings if he chooses to try this combo.

[Mish]

Originally Posted by supremedan

Swim would like to know if any SWIM tried this combination . Swim wants to use a higher dose of GHB with out getting sleep.SWIM would like to know if by any chance ritalin will kill some of GHB euphoric properties or enhance it.

PEACE!!

Old thread, I know, but SWIM thought it would be worth resurrecting as he recently tried this combo. SWIMs first time with GHB he took 3g over the course of 1.5 hours, at half hour intervals and had a very nice effect, but thats it. Just a very nice effects nothing overwhelming. The next day, SWIM took around 30mg of Ritalin over 6 hours to get some work done. SWIM always finds that low doses of stimulants - even when taken early in the morning - interferr with SWIM's sleeping patters that evening (SWIM suffers from insomnia). So at around 8pm, 5 hours after the last 10mg of Ritalin, SWIM took 3g in one go dissolved in some apple juice. One hour later SWIM felt some mild feelings of being "off", better mood and slightly more chatty, but hardly an extremely noticable effect. This is odd as 3g, according to Erowid and various other sites suggesting dosage, that is a fairly large dose. SWIM beleives that the lack of effects was partially due o the tolerance from the previous evening, combined with the lingering stimulant effects from the methylphenidate. Thus, the point of this thread i that taking GHB with Methylphenidate will mean you won't feel it as much and are more likely to increase the dose. The mixing of high doses of GHB with what is almost an amphetamine could lead to convulsions and bizzarre states of in-out consciousness.

[Psych0naut]

Pharmalogically Ritalin(methylphenidate) is almost the same as cocaine, though it has a lot longer duration, around 4-6x more.
SWIM extensively tried the combination of GHB and methylphenidate and he liked it a lot, it certainly made it more euphoric.
But combining a strong stimulant with a strong depressant puts a lot more strain on the body than just methylphenidate on itself.

[Mish]

SWIM knows that mixing strong depressants with stimulant puts more strain on the body, but does this still apply if used afterwards? For example, using GHB on an MDMA comedown; the bodily effects are still there but the person it not actually combining the two as a combo..?

[Lehendakari]

SWIm has triedd gbl+MPH and it was very euphoric and very pro-sexual but gbl wears off too fast, lingering over-stimulation afterwards

[MrG]

Originally Posted by Mish

SWIM knows that mixing strong depressants with stimulant puts more strain on the body, but does this still apply if used afterwards? For example, using GHB on an MDMA comedown; the bodily effects are still there but the person it not actually combining the two as a combo..?

Actually I would like to know more about the, oft mentioned, bodily strain of mixing uppers with downers. Does anyone have any research data on it?

There is also the fact that the way that G supresses the CNS is different to most downers, in that it is often pointed out in research data that G induces changes in oxygen use and metabolism that leave actual oxygen/carbon dioxide levels unchanged, therefore raising the question of whether the combination of a stimulant and G is as harmful as many assume.

It has been mentioned before, however, that the biggest risk factor in combining G and a stimulant is more likely to be the greater loss of mental faculty whilst still being mobile due to the stimulant allowing physical mobility while increased dosing of G leads to greater intoxication, thus exposing the user to accidental harm.

[Lehendakari]

According to erowid GHB might behave as an stimulant at low doses:

The recent development of truly selective GHB receptor agonists has allowed scientists to finally understand GHB's mechanism. At low doses, GHB is binding almost exclusively to the GHB receptor, a receptor which, through pathways not yet understood, stimulates the release of glutamate (the major excitatory neurotransmitter) in the cortex. As the dose of GHB increases, more and more GHB is binding to, and activating, the inhibitory GABA-B receptor. This leads to the sedative/hypnotic effect of GHB. The selective GHB receptor agonist t-HCA (fig 1) does not cause sedation of any kind, and is presumably a stimulant as it leads to seizures4.

[toe]

My sooper-dooper rx-interaction checker noted zero interactions between "Xyrem" and methylphenidate.

[Mish]

Originally Posted by toe

My sooper-dooper rx-interaction checker noted zero interactions between "Xyrem" and methylphenidate.

This is true, and SWIM has used the combo as a great study aid many a time; starting with railing the Ritalin, and tailing off with some GHB to, a) kick the - albeit minor - comedown; and b) because the dopamine adds more motivation!