Tolerance Fighting

[blinkKDX]

Swim remembers a post where some drugs were used to fight tolerance of amphetamine, but is unable to find it...

what are the drugs/supplements used to fight tolerance?

[blinkKDX]

a idea...

muria puama is known as a source of L-Dopa...but the problem is bioavailiblity, and weak supplemental extracts...

there's a new one out by usplabs that has 100% saponins...from feedback of other users swim understands it's one heck of a great supplement.



here's what swim is going to do for all those who experience amphetamine tolerance....

he is planning on running this and is going to keep a log here so others can get first hand experience...

he is going to start with this, but would like someone to put up the other few supplements that one can use... he knows glutamine is one, and knows of a glutamine ethyl ester which is supposed to be a much more bioavailible and will run that AFTER Powerful

[svenghali]

This piques my interest, as SWIM used to be heavily into amphetamines but quit due to his high tolerance, and an inability to differentiate between what he thought was baseline, from high, and actual baseline. I'm off-topic, sorry. It's been quite a few months since this madness stopped, and he hopes that your experiment proves successful, as it could allow him to play with amphetamines again, without the risk of running up another tolerance.

[hoodabudda]

take a few hydros or benzos and lay off it for a day or two.that will do wonders for tolerance.to get dopamine stores refilled eat 5 or 6 equel sweetener packets.they contain phenalyanine(sp?) which is metabolized directly into dopamine.as for suppliments scroll down the page to magneseum. http://www.bluelight.ru/vb/showthread.php?t=199749

[svenghali]

Thanks, I think you mean phenylalanine, but you've been very helpful.

[Jiggles]

This might be an incredibly stupid uninformed suggestion as I have done little research on the actual efficacy of this, but about a month and a half ago SWIM had a nice Zicam DXM trip and abstained from Adderall and tobacco use for about a week. Upon and again, his tolerance seemed to be down considerably. The cigarette blazed him into nicotine buzz for the first time in ages, and he only needed half his usual dose of Adderall to feel gooooood.

SWIM seems to recall something about DXM effecting NMDA receptors, and there is a fleeting memory of reading something about NMDA receptors affecting dependency/tolerance. If anyone more educated on such matters would care to respond it would be much appreciated and in the meantime SWIM shall consult his search engine

[svenghali]

I have heard quite a bit about DXM potentiating nicotine and vice-versa, but not as much about amphetamine. Also, I don't think amphetamine is active upon NMDA receptors...

[Jiggles]

Originally Posted by svenghali

Also, I don't think amphetamine is active upon NMDA receptors...

I don't think tobacco is active upon NMDA receptors either.. The antagonist activity that DXM has upon NMDA receptors apparently MAY be helpful against any kind of addiction/dependence. And it's not just DXM, ever heard of ibogaine? It also exhibits antagonist activity on the NMDA receptors, and is helpful with addictions and possibly tolerances of many substances. Problem is, it's unknown of that's exactly the reason behind it..

SWIM did an experiment and took DXM again 2 days ago, and he reports that the next day when he took Adderall, his tolerance indeed was down again. So who knows, SWIY should try it for themself and see if it works.

[Jiggles]

Oh ya SWIM forgot one thing. Correct SWIM if he is wrong but he has heard that nicotine is broken down by the same enzyme that breaks DXM down, except nicotine has the higher affinity and therefore more DXM is left untouched, which can explain why people who use tobacco while on DXM experience a boosting effect. That may be what SWIY meant by "I have heard quite a bit about DXM potentiating nicotine and vice-versa, but not as much about amphetamine.." The addiction cutting and tolerance busting properties of DXM have little if anything to do with anything nicotine specific..

[hoodabudda]

Originally Posted by Jiggles

This might be an incredibly stupid uninformed suggestion as I have done little research on the actual efficacy of this, but about a month and a half ago SWIM had a nice Zicam DXM trip and abstained from Adderall and tobacco use for about a week. Upon and again, his tolerance seemed to be down considerably. The cigarette blazed him into nicotine buzz for the first time in ages, and he only needed half his usual dose of Adderall to feel gooooood.

SWIM seems to recall something about DXM effecting NMDA receptors, and there is a fleeting memory of reading something about NMDA receptors affecting dependency/tolerance. If anyone more educated on such matters would care to respond it would be much appreciated and in the meantime SWIM shall consult his search engine

DXM is an nmda antagonist which means that it blocks it from being released,like magneseum it would help the neuro transmitters replenish its stores.By forcing the neuro transmitter to function at lower levels,the brain would compensate for this by increasing sensitvity of the receptor,thus lowering tolerance.yet dxm only lasts for 6-8 hours and it would take more than 8 hours s to make the body compensate for the lower levels.swiy would probably have to be on dxm for a good 3-5 days straight to make a difference. At recreational doses this would be potentally harmful to the brain, but safer doses under,say 100mg might work just as well but swim isn't sure. Your strong effect was probably due to the tolerance break. Even abstaing for 24 hours makes a huge difference with amphetamines. A week and your tolerance would be pretty close to what it formerly was. If swim remembers correct, 14 days is the time that it takes to return to the no tolerance level. But the first time you do any drug will be the best and it will never be exactly the same again,no matter how long you abstain. Swims theory for why this is, is that swiy have a memory of the first time in you brain forever,and on your first time it was a totally new experince to the brain,and just having that memory of the first time makes the brain mentally prepared. Swim thought this up while he was blazed so he could be totally wrong but if u think about it, it makes sense. he likes to call it 'cognitive tolerance'. well thats swims 2 cents.

[stoneinfocus]

Corticosteroids, L-thyroxine, triiodthyronine... 3 to go. oh- and alcohol, but not very advisable but these 3 (4) make up for a good go *lol*