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Old 10-01-2007, 05:28
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NAC. Quit CWE? Liver help.

Swim heard of NAC, which is supposed to help the liver pass APAP. Swim started taking one a day. Any swims know anything about this? Here's a quote.

When you take a normal amount of APAP, a toxic metabolite called NAPQI is produced. Normally, your liver's supply of glutathione is able to bind to the NAPQI and prevent it from doing any harm. But when too much APAP is present, you do not have enough glutathione to bind to all the NAPQI and it's free to damage liver cells.
So why not just take glutathione? It's not very well-absorbed orally and a lot of it is wasted before it can do any good. NAC is much more well-absorbed and it can bind to NAPQI all by itself, it increases the effectiveness of your liver's own glutathione, and it speeds up the creation of new glutathione.
As far as how much APAP is safe- we just don't know. But every time a guideline comes out, it's lower than the preceeding one. I've heard 6, 4, and 2.6 grams. For people who drink or had a prior history of alcoholism, this is a very big deal. Same goes for Hep-C and other liver conditions. And taking APAP in significant amounts daily is also a big deal- that figure is always lower than how much is allowed in one day (the one day guideline does not assume daily use). I can't answer what a safe amount is for an individual person, so please no one PM me about that because I just don't know (and no one does). What I can tell you is that if you feel you are pushing it, you should start taking NAC with each dose.
You will be doing your liver a big favor.
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