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  #1  
Old 02-01-2007, 20:27
whorse whorse is offline
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Gabapentin and opiates?

Gabapentin is an anti-epileptic that is relatively weak on its own, but SWIM has heard that when mixed with benzos it makes them exponentially stronger (but he cannot confirm this). SWIM has also heard that it is used to treat opiate addiction and weaken withdrawal symptoms. What would happen if SWIM were to take a mix of a conservative amount of opiates and gabapentin? Would it negate the effects of the opiates or make them stronger? Please enlighten SWIM

Also what would happen if SWIM added benzos to the mix?

thanks
  #2  
Old 02-01-2007, 22:30
thegoodfight thegoodfight is offline
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Re: Gabapentin and opiates?

Swim knows a friend who has mixed opiates and gabapentin. Gabapentin can give you a drunk kind of feeling and even give you an "upper" type feel while making you less coordinated. Swim doesn't think it potentiates the euphoric effects to terribly much. Swim would say that it is a decent replacemant for GHB, but without the visuals.

Adding 20mg of diazepam to 1g gabapentin did not seem to make the euphoric feeling much better but did give swim and INCREDIBLE nights sleep!

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  #3  
Old 03-01-2007, 08:06
whorse whorse is offline
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Re: Gabapentin and opiates?

swim just tried 600mg gabapentin, 7.5mg hydrocodone and 1mg xanax and didnt feel much, maybe even less than swim would have if he didnt take the gabapentin at all.
  #4  
Old 03-01-2007, 19:21
thegoodfight thegoodfight is offline
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Re: Gabapentin and opiates?

Swim found that gabapentin is a strange drug. Swim/y may be able to take a hight dosage, but once swim/y hits that and exceeds it, it gets messy. It is much like GHB in a way. Take too little and no effect, too much and swiy is out of control.

This dose is mainly for recreational use. If swim/y is using for medical purposes, it doesn't have that fine line dosage..
  #5  
Old 04-01-2007, 22:37
cckatie45 cckatie45 is offline
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Re: Gabapentin and opiates?

swim takes gabapentin 800 4x/d plus oxicodone...it enhances the pain relief. swim was in an car accident and broke everything from the neck down and was left w/a spinal cord injury. it works for swim

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thanks for your experience
  #6  
Old 06-01-2007, 08:29
DrMuffy DrMuffy is offline
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Re: Gabapentin and opiates?

Gabapentin has been sold (off label) as a pain releiver for pain due to nueron damage, so the analgesia will probably be increased, it is not opiate or benzo tho....
  #7  
Old 06-01-2007, 12:10
cckatie45 cckatie45 is offline
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Re: Gabapentin and opiates?

true... but it boosts the effect of the opiate for pain.
  #8  
Old 07-01-2007, 11:10
Forthesevenlakes Forthesevenlakes is offline
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Re: Gabapentin and opiates?

Quote:
Originally Posted by cckatie45 View Post
true... but it boosts the effect of the opiate for pain.
Although it may potentiate the analgesic effect of opiates due to the fact that it can relieve some neurological pain (pain signals arising in the CNS itself, rather than the peripheral nervous system), SWIM does not think that Gabapentin would increase the recreational/euphoric effects of opiates. Gabapentin has some strange effects on its own, not to mention when it is combined with other drugs, so SWIM advises against this combination for recreational use. At best it would be ineffective, at worst, potentially risky.
  #9  
Old 07-01-2007, 11:32
DrMuffy DrMuffy is offline
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Re: Gabapentin and opiates?

Thanks for the info SWIforthesevenlakes, but before he said that, SWIdr gave some gabapentin/opiate trials a try. He combined on two separate occasions:

1. On his first experience he used hydrocodone 30 mg, and gabapentin 800 mg. The experience seemed a little more opiate-like (but that could be psycosemetic (placebo) than usual and more analgesia. NOTE-SWIdr had lower back ache and a very bad head ache before and it solved the trick, but hydro could probably do that alone.

2. On his second combo experience he took 20 mg oxycodone and 1200 mg gabapentin. The experience was basically same as the first. SWIdr felt slightly stimulated though, and had very strange food cravings (he did not smoke marijuana). The experience seemed stronger and lasted longer, but of course it could have been placebo, (but SWIdr usually knows if a drug is working and when it is placebo effects).

Conclusion: Gabapentin can add a little bit to opiate experiences, but not much. It would be better to drink some grapefruit juice and or combine a benzo (NOTE: SWIdr is not condoning the combo of more than one CNS depressant, as they can be very dangerous!).

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Gabapentin is known to excrease appetite.
  #10  
Old 07-01-2007, 23:19
thegoodfight thegoodfight is offline
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Re: Gabapentin and opiates?

Quote:
Originally Posted by DrMuffy View Post
2. On his second combo experience he took 20 mg oxycodone and 1200 mg gabapentin. The experience was basically same as the first. SWIdr felt slightly stimulated though, and had very strange food cravings (he did not smoke marijuana). The experience seemed stronger and lasted longer, but of course it could have been placebo, (but SWIdr usually knows if a drug is working and when it is placebo effects).
Swim has done the same experiment. 20mg OC, the 600mg Gabapentin and then another 600mg 2 hours later. SWIM had the munchies like swim had jus smoked a few bowls of some prime MJ. This combo did seem to make Swim a little wired, euphoric and somewhat drunk. Overall a good feeling.

The next time, swim added 600mg Lyrica to the mix. 20mg OC, 600mgGabaPentin & 300 Mg Lyrica and the same 2 hours later (no more OC though). This gave amplified effects of the prior experience. Swim thinks it is somewhat like a coke/weed/alcohol feeling that also eliminated body pain. Pretty darn good feeling, just wish there were no munchies

One thing swim will say is that there is a pretty bad hangover from the lyrica and gabapentin. It fells like swiy has had a rough night boozing, not fun, but a little gabaP or lyrica takes that away. So if SWIY plans on trying this, swim suggests keep 300mg GabaP and 225-300mg Lyrica for a dose the next day.
  #11  
Old 08-01-2007, 01:04
monkeygone2heaven monkeygone2heaven is offline
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Re: Gabapentin and opiates?

oh my oh my... first of all, swim is not above it but remember you are not supposed to drink with gabapentin.

swim has taken gabapentin alone and with opiates -- but she has been prescribed these meds for a chronic nerve pain condition and this makes a huge difference.

gabapentin (and other anticonvulsants prescribed for neuropathic pain) do not act on opiate receptors and unless you have a neuropathy (pathology in your nervous system) they will not lead to any pain relief. think about SSRI antidepressants - they can help depressed patients but they don't make healthy people euphoric. same logic applies.

in fact these drugs work only on a small percentage of pain patients to begin with...

therefore unless you are a pain patient of a specific sort, do not expect "pain relief" or "opiate-like" effects from gabapentin. they're not similar at all. if you think you felt opiate like effects from gabapentin, it's probably just placebo.

what you can experience on gabapentin are a variety of lovely (side) effects like lethargy, mental slowing (commercial name: neurontin, doctors call it: morontin), paresthesias, taste changes, and my favorite: you WILL gain weight on gabapentin believe me... if you want to suffer needless side effects of anticonvulsants, you may want to try topiramate - at least you'll stay thin or lose weight. http://www.crazymeds.org/topamax.html

for gabapentin on the same site: http://www.crazymeds.org/neurontin.html

one final thing, anticonvulsants are notoriously hard on the kidneys. drink loads of water and refrain from regular use.

one would have to pay swim a lot of money to take gabapentin rather than the other way around so hard to believe there are people who willingly take the dumbifying, zombifying evil bugger and presumably pay for it! but to each their own... ;-)
  #12  
Old 08-01-2007, 05:36
thegoodfight thegoodfight is offline
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Re: Gabapentin and opiates?

^SwiMonkey - Swim meant a "hangover" from the gabapentin and lyrica. No alcohol was involved. The next day felt like an alcohol "hangover"

Also, swim has nerver damage, so that explains the pain releif.

Finally swim doesn't think gabapentin is for him anymore than 4g a day of acetominiphen is.
  #13  
Old 08-01-2007, 11:52
cckatie45 cckatie45 is offline
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Re: Gabapentin and opiates?

Swim has a spinal cord injury and never takes gabepenton alone...it is alwayes takes w/oxicodone and YES it does boost the effect of pain relief.
  #14  
Old 08-01-2007, 17:36
monkeygone2heaven monkeygone2heaven is offline
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Re: Gabapentin and opiates?

Quote:
Originally Posted by cckatie45 View Post
Swim has a spinal cord injury and never takes gabepenton alone...it is alwayes takes w/oxicodone and YES it does boost the effect of pain relief.
for nerve pain gabapentin and similar drugs have been quite successful. they don't work for everyone but when they do, their effect is significant.

swim is glad to hear gabapentin and oxycodone combination helps with your pain relief.
  #15  
Old 02-11-2008, 15:19
gmeziscool2354 gmeziscool2354 is offline
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Re: Gabapentin and opiates?

dude, i have my pill bottle right here and the the precautions it doesn't say anything about alcohol. I don't know if that means its safe to mix that seems like confirmation to me

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My Rx of oxy has no warning of death, only sedation, from comb/excess alcohol, I'm not going to get pissed while on meds simply because my pill bottle didnt warn me. lol. sorry if you were being sarcastic. no points taken or anything.
  #16  
Old 25-02-2010, 20:10
m3ar2k m3ar2k is offline
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Re: Gabapentin and opiates?

My friend took 2 7.5s of oxycodones, then an hour later 3 600mg gabapentins, then an additional oxycodone. He is claiming it is not doing much more than the normal effects of the oxys. It has also only been an hour since he took the Gabapentins, will he be feeling the effects later in the day? or should he already be feeling them?
  #17  
Old 25-02-2010, 20:16
Flying Mind Flying Mind is offline
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Re: Gabapentin and opiates?

Some interesting info SWIM found on it. Apperntly it just makes opiates less effective and the gabapentin more efficient. BUT it is unclear whether the same stays true with artificial opiate drugs.

Quote:
But people who take Neurontin (gabapentin) for pain, as fibromyalgia is far too common in the bipolar community, Neurontin (gabapentin) has a weird drug-drug interaction with opiates. The opiates make Neurontin (gabapentin) work better, but the Neurontin (gabapentin) makes the opiates less efficient! It's weird, and since Neurontin (gabapentin) isn't really metabolized, who the hell knows what the deal is with that. This is spelled out in the PI sheet, but who reads those, right? When you take Neurontin (gabapentin) along with hydrocodone (a.k.a. Vicodin), it decreases the bioavailability of the hydrocodone by up to 22%! While the bioavailability of Neurontin (gabapentin) is increased by 14%. It's even odder when combined with morphine. As Mouse points out there's an element of timing involved, as XXXXX (deleted gov link) on the interaction has morphine administered two hours before the Neurontin (gabapentin). The morphine was unaffected, having pretty much been on its way towards peak plasma, but the Neurontin (gabapentin) bioavailability was increased by a whopping 44%! We have no idea if this effect carries over to the artificial opiods, like Demerol or buprenorphine.
Meanwhile taking naproxen (a.k.a. Aleve) increases Neurontin's bioavailability by 12-15%, while there is no apparent affect on naproxen's bioavailability

Last edited by Flying Mind; 25-02-2010 at 20:22.
  #18  
Old 25-02-2010, 21:39
Helene Gold member Helene is offline
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Re: Gabapentin and opiates?

There's a thread on the subject of gabapentin (as prescribed for opiate withdrawal) over in the heroin forum -

SWIM got Gabapentin prescribed for withdrawals. Any experience?

H
  #19  
Old 24-10-2011, 22:01
1Luckyj 1Luckyj is offline
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Re: Gabapentin and opiates?

Gabap is crap. I've been taking it for neuropathic pain for years. Thinking about tappering off cuz benefits are minimal compared to the side effects, which include fatigue and general laziness, impaired cognitive speed, and an inability to tolerate alcohol. Bascially it just makes you feel dizzy.

Doesn't potentiate anything as far as I can tell...not pain relievers (otc or opiate), not benzos.

The worst part is you can develop a strong chemical dependance over time. Quitting can result in seizures and even death, which of course the doctor failed to mention.

1Luckyj added 2 Minutes and 14 Seconds later...

Quote:
Originally Posted by Helene View Post
There's a thread on the subject of gabapentin (as prescribed for opiate withdrawal) over in the heroin forum -

SWIM got Gabapentin prescribed for withdrawals. Any experience?

H
No go for that either. Gabap is lame.

Last edited by 1Luckyj; 24-10-2011 at 22:01. Reason: Automerged Doublepost
  #20  
Old 25-10-2011, 05:00
Petri6 Petri6 is offline
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Re: Gabapentin and opiates?

SWIM has to disagree with other posters in this thread. For SWIM, gabapentin enhances the nodding effects of opioids without reducing the euphoria (as benzodiazepines or alcohol would for SWIM). In essence, for SWIM combining gabapentin with opioids produces similar potentiating effects than combining opioids with certain antihistamines (hydroxyzine and cyclizine) or tizanidine.
  #21  
Old 27-10-2011, 01:31
1Luckyj 1Luckyj is offline
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Re: Gabapentin and opiates?

There is no right answer. Especially when it comes to neurobiology, everyone is VERY different.

Neurontin does help many people, just not me, which sux cuz I'm addicted to it now.
  #22  
Old 27-10-2011, 15:30
LostControl LostControl is offline
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Re: Gabapentin and opiates?

I was prescribed gabapentin by my doctor along with oxycontin for chronic pain. I'm one of those odd people who had a terrible reaction to gaba - I had hallucinations, felt very dopey - it was not a good experience at all. I only took about 3 tablets - tossed the rest out. Maybe without the oxy it would have been better. For now I'm just on oxy, and doing fine.
  #23  
Old 30-10-2011, 18:31
DiabolicScheme DiabolicScheme is offline
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Re: Gabapentin and opiates?

I love it when combined with Kratom, while not a opioid in a strict sense its effects are very similar.

For me it definitely increases the euphoria but on the downside cognition really suffers on this stuff and if too much is taken you'll be in trouble. It'll be like you drank too much and for me for some reason the stuff lasts forever, like 8 hrs.

As far as adding benzos..I DO NOT recommend you combine them with opioids this is known to cause death from accidently overdoses as both can potentiate respiratory depression when taken together. If you are going to ignore that advice, please at least lower your dosage of both.

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Old 05-11-2011, 03:27
m000nman m000nman is offline
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Re: Gabapentin and opiates?

for scientific research purposes (of course) i once ingested 900mg of gabapentin and 6mg of lorazepam. i have virtually no memory of the day, aside from recalling having very very apperent double vision. so i would say a very significant yes to potentiating benzos. as for opiates, id say no real noticable change. i ingested 600mg gabapentin and 20mg oxycodone w/ no tolorance. i noticed maybe a mild decrease in analgesia and no noticable change in euphoria. though i was much more talkative than with opiates alone
  #25  
Old 03-01-2013, 08:10
PoopCoveredVagina PoopCoveredVagina is offline
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Re: Gabapentin and opiates?

If you are trying to get a recreational use out of Gabapentin. The Little Green Elf tells me that he takes a 300mg Capsule of Gabapentin and 20 - 30 mins later he downs his Benzo's(Xanax, Kolonapin, and Ativan).
The Little Green Elf tells me the Gabapentin Potentiates the Benzo's Big Time, and later on(After the Benzo's kick in, The Gabapentin will kick in shortly after... If timed like I just explained).
The Little Green Elf then takes a 25 - 50mg Dose of Doxylamine Succinate. The Little Green Elf tells me this kicks his ass and no problem Nod's out!

PCV

PoopCoveredVagina added 6 Minutes and 1 Seconds later...

That is if you have a HIGH tolerance...

The Little Green Elf takes 10mg of Kolonapin, then 300mg's of Gabapentin, and finally 25mg - 50mg's of Doxylamine Succinate.

PoopCoveredVagina added 18 Minutes and 45 Seconds later...

The Little Green Elf says, as for Opiates They do not and if they do you will feel the Gabapentin over your Opiate. Him and his friends also say the same thing.
PCV

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Last edited by PoopCoveredVagina; 03-01-2013 at 08:10. Reason: Automerged Doublepost

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alcohol, analgesic, bioavailability, drug, drugs, euphoric, gabapentin, gabapentin recreational use, hangover, morphine, narcotic, opiate addiction, opiate withdrawal, opiates, opioid, opioids, pain relief, placebo, topiramate, withdrawals

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