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Rectally, of course, will give the highest absorption efficiency and work in short time. For many people this isn't an option however, for various reasons.
Assuming you are talking about IR adderall, just popping it in your mouth and swallowing on a fairly empty stomach is probaby the most effective way you can find. Drop the pill in a glass of grapefruit juice and drink it, and you may find that works even better thanks to grapefruit's magic properties and the adderall being dissolved already.
Snorting will hit you fast but won't be nearly as efficient as the other methods, plus it messes up your nose. I really wouldn't recommend this method.
As for plugging ie. rectal administration yep just shove it up ya butt, peeling off plastic coating helps speed up absorbsion though
As for baking soda:
The absorption & effects of Amphetamines are also dependent on the ph of the stomach & the urine. An alkaline agent such as Baking Soda (dissolved in water) increases the absorption of amphetamines in the stomach, and baking soda in higher doses makes the urine alkaline, greatly slowing the elimination & thus prolonging the duration & effects of amphetamines (although taking baking soda for this effect is supposed to be pretty bad for your health- Your body constantly tries to find a ph equilibrium, in both the stomach & especially in the blood which is neutral in ph except with severe dehydration or serious health problems). Acidic agents/food/drinks such as certain fruit juices decrease the duration & effect of amphetamines (thus it is better to drink water with Adderall/Dexedrine instead of fruit juice or Colas
I never heard of the baking soda thing, surprisingly. I'm definitely going to look into that because SWIM could definitely use it. As far as insuffulating goes, SWIM finds it obviously hits very quickly, but he doesn't find it particularly strong or long lasting. If he insuffulates say 15mg, it would probably be stronger than ingesting 15mg, but it would lose its effect within an hour. If using adderall for its intended purpose (or for something non recreational like studying) I believe oral consumption is the best route because it was obviously dosed in an effective oral amount. If SWIY is looking to conserve due to a lot of studying and not a lot of adderall, insuffulating is a good way to do a little (say 5mg) and stay alert and focused for around 2 hours.
rectal administration is mentioned above as a good way to administer adderall... how would one go about doing this? do they just shove the pill up one's butt? or do they hafta do something else?
The most efficient way to do this would probably be to grind the pill or pellets into a fine powder, and dissolve in water. Then squirt the resulting solution into the rectum with an oral syringe. Just shoving a pill up the butt would probably work too, but wouldn't be nearly as effective.
While not as imaginative as squirting it up one's butt, I've heard it said that crushing the XR pellets in a shot glass with the back of a screwdriver is very efficient. Taking said fine powder and placing it under one's tongue might be a reasonably fast means of introducing it into the bloodstream. (opinions?)
Another question might be: what if one stirred the powder into some vodka? would it absorb under the tongue faster, more efficiently? Is the whole under the tongue thing a myth?
SWIM heard a speech by a Dr. recently explaining the use of antacids that may shed light on this matter. We think that taking antacids (same as baking soda) reduces acid in the stomach to relieve the pain of heartburn. While this assumption makes a lot sense the actual process isn the stomach is when we have heartburn we are suffering from a lack of the digestive acids needed for the amount of food ingested. A good test is when you have an onset of acid reflux, heartburn, etc. instead of taking an antacid you take a teaspoon or 2 of vinegar. This results in raisn=ing the acidity of the stomach and thus reduces or eliminates the pain completely. So what does this mean as far as antacids go. The antacid in dissolved into the stomach giving it an immediate rise in alkalinity. The natural response of the stomach is to do what the vinegar would do. Raise the acid level by flooding the stomach with a high dose of acid to aid in digestion. So essentialy when one takes an antacid it causes the body to raise the acidity to achieve the original goal of digestion through proper amounts of digestive acid. This is why drinking grapefriut juice and taking tagamet before taking certain chemicals can effectivly raise the effecacy of the drug. This has been discussed many times here trying to save money and product by raising bioavailability when things rae taken P.O. SWIM doesn't know of any way of making a quantitative analysis of amounts of these precursor items needed to make the best "high" but I would think that 8oz. glass of Grapefruit juice and 200-400mg of tagamet taken 1/2 hour before might do the trick. Any help on that matter is quite welcome. Of course this is all conjecture on SWIM's part having heard the Dr. and assessing his knowledge with what little SWIM knows about chemical reactions and drugs. I hope this sheds a little light on this matter that comes up so often on this board though.
Actually grapefruit juice shouldn't have a synergistic effect on Adderall; Adderall is processed by the enzyme CYP2D6 (one of the CYP450s), and sodium bicarbonate is an inhibitor of these enzymes so the drug remains in the blood stream in its active form for a longer period of time, since less receptors are available to metabolize it to a form that is inactive and can be excreted via the urine.
Grapefruit juice effects the enzyme CYP3A4 which is responsible for the metabolism of many drugs (Lipitor, simvastatin, etc.) but in this case since adderall is a weak acid, if you take it with something acidic, its going to increase its excretion (like dissolves like). By adding baking soda to the GI tract before taking Adderall orally, you're creating a more alkaline environment so the drug will be metabolized slower, and thus again will stick around active for a longer period of time.
However oral doses will always have the problem of being metabolized greatly via the liver to inactive forms, thus is the least efficient delivery method if you're looking to get a high off the drug in my opinion. To insufflate nasallty does allow some drug to be absorbed by the nasal mucosa and avoid that liver metabolism, but as you know if you've done this much... that "drip" ends up in your stomach and is metabolized that way.
Rectally probably is most effective but least desirable/feasible for most. In the past i've found that consuming a saturated sodium bicarbonate solution, then going to work crushing up some pills, bumping a couple little lines, then swallowing the crushed powder works very efficiently.
Another final option is to crush tablets and place the powder under your tongue and allow it to absorb their. Alternatively, tablets can be placed between your gums and cheek, and will be absorbed bucally, which also avoids that annoying inactivation that the liver causes when the drug is taken orally, so the drug gets into the blood stream in an active form at a higher concentration.
Speaking by a combo of education and experience, so partially opinion. I had always though nasal route was the best way to go, but recent research seems to be indicating that there is some inactivation similar to the liver going on when drugs are inhaled...
pharmer2011 added 47 Minutes and 1 Seconds later...
Originally Posted by MorganNY
Would one be wrong to think that any OTC acid reducer, Zantac, Tagamet etc. would have the same effect? Assuming reducing stomach acidity is the goal?
I would stick with the quick release, basic, chewable, chalky, Tums, Rolaids, type of acid reducers. Zantac takes longer to take effect on the pH of the stomach and its mechanism of action is different than normal antacids. As for Tagamet (cimetidine), although it doesn't have any listed interaction with amphetamines, it has a HUGE amount of interactions with other drugs (which do include regular antacids like Tums, Maalox) so I always recommend staying away from that if possible.
If you take Zantac regularly already... then your stomach is probably all set up at a higher pH. But otherwise, I'd suggest saving your money and choking down the chalky tums-type antacids. Its your safest bet, cheapest, and they will work the quicker than the Zantac because you generally chew them and they dissolve rapidly in the stomach, changing the pH quicker, so you don't have to wait forever after taking them to take the adderall.
Or just use baking soda.... I choke down seriously salty solutions since i don't like taking traditional antacids, and that seems to do the job, especially as far as duration of action, not as much so as for intensity.
I'm still seeking out shorter duration, higher intensity methods that don't involve shoving solutions up my ass, but, have sadly yet to find anything. In the mean time, as I mentioned just before, I dissolve them in my mouth under the tongue or between the gum and cheek for the most part.... according to some data up to 85% of amphetamines are inactivated by the liver and GI wall following swallowing the drug, while absorption through the mucosa in the mouth via buccal administration, numbers range from 40-60% of the drug still active once absorbed.
Last edited by pharmer2011; 09-08-2009 at 08:42.
Reason: Automerged Doublepost
Drop the pill in a glass of grapefruit juice and drink it, and you may find that works even better thanks to grapefruit's magic properties and the adderall being dissolved already.
grape juice is full of vitamin C which takes away from swiy
Muska added 6 Minutes and 28 Seconds later...
how does one edit? - Anyways swim will either break up and just drop, or snort, swim used to crush up xrs and take it with a shot of milk, swim loves milk and its great to drink as it keeps your stomach more base. ie less acidic.
Last edited by Muska; 28-08-2009 at 00:59.
Reason: Automerged Doublepost
Here it is boys and girls, the most efficient method that doesn't involve needles or sticking anything up your butt.
1. Take your pills (or if you have capsules the little balls inside the capsule) and crush them into a very fine powder.
2. Seperate your powder into four equal piles, and turn those piles into lines.
3. Blow your nose and make sure there's as little gunk in there as possible.
4. Snort the first two lines. One line with your left nostril, and one line with your right nostril.
5. Here's the tricky part. Wait about 5-20 minutes, this amount will depend on the person. I usually wait about 10 minutes. Don't wait so long that your nose starts to get stuffy though.
6. Repeat step 4 with the other two lines.
7. Once your nose starts to get runny take two squares of toilet paper and make them into two small balls and put them in your nose, one for each nostril. This will stop you from having to sniffle to keep in your now precious nose goop.
8. After about an hour has passed take out the balls and clean your nose out.
The method works great for a number of reasons. First being that you don't lose product to the nasal drip. The second is that because of the time you waited you will have a greatly extended peak. For proof of this think of a graph of two equal curves, shift one to the right a bit, then add them together. Now compare this to what it would loom like if you didn't shift one of them. Looking at those graphs you may think, "but if I shift it then the peak isn as high", although that would be right when looking at the graph it would wrong when thinking about the drug. The bumps allow the product to be more spread out in your nose and less "chunky" than it would be if you did it in one big line. The other great thing about this method is that you have both nostrils absorbing your powder, therefore it hits you a bit faster.
My Monkey has personally tried many methods of insuflation, but this by far works the best.
Trogdor added 4 Minutes and 50 Seconds later...
Oh yeah... Another thing. This method is only for those looking for the "high". If you want to concentrate or study, then for gods sake just take it orally. If you take it orally the waiting still applies though. If you're planning on taking more than one then take the second about half an hour after the first. This will make it much more "smooth".
Last edited by Jatelka; 28-08-2009 at 19:50.
Reason: Automerged Doublepost
Ah your right swim never knew that for some reason I always believed it was around 4. Eh rather be in the middle than drinkin dew or something.
Muska added 5 Minutes and 19 Seconds later...
actually swim just realized dew has low ph too, whats going on.
Dew and all sodas have carbonic acid and are acidic swim him self cannot find any basic drinks besides making a horrible baking soda or tum and water mix best bet if swiy is wanting their stomach as basic as possible is to use water.
also returning to the original question at hand swim thinks the most effective way of taking adderall would be baseifying swiys stomach with some tums or a baking soda/ water mix a half hour or so before on an empty stomach and taking all but half a pill and snorting the half pill once the swallowed pill starts kicking in. The amount of binders and amount that gets clogged in swiys nose really stops how much swiy can insufflate.