STUDY: monoamine transmission effects of various chemicals

[radiometer]

I found this posted elsewhere today. This will be published in the European Journal of Pharmacology. It would be fantastic if comeone could come up with the full text of this study:

The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain

In Press, Accepted Manuscript, Available online 12 December 2006
Fumiko Nagai, Ryouichi Nonaka, Kanako Satoh and Hisashi Kamimura


We developed a reproducible, simple, and small-scale method for determining the re-uptake and release of monoamines (dopamine, serotonin (5-HT) and norepinephrine), using rat brain synaptosomes. These assays were then applied to study the effects of different kinds of nonmedically used psychoactive drugs on monoamine re-uptake and release. The phenethylamine derivatives, 4-fluoroamphetamine, 2-methylamino-3,4-methylene- dioxy-propiophenone (methylone), 1-(1,3-benzodioxol-5-yl)-2-butanamine (BDB), and N-methyl-1-(1,3- benzodioxol-5-yl)-2-butanamine (MBDB), had strong inhibitory effects on the re-uptake of dopamine, 5-HT and norepinephrine. 4-Fluoroamphetamine, methylone and BDB also strongly increased the release of the three monoamines, but MBDB increased 5-HT and norepinephrine release, but had little effect on dopamine release. However, 2,5-dimethoxy-4-iodophenethylamine (2C-I), 2,5-dimethoxy-4-ethylphenethylamine (2C-E), 2,5-dimethoxy-4-chlorophenethylamine (2C-C), 2,4,5-trimethoxyamphetamine (TMA-2) and 2,4,6-trimethoxyamphetamine (TMA-6), which are methoxylated phenethylamine derivatives, slightly influenced the re-uptake and release of monoamines. α-Metyltryptamine (AMT), a tryptamine derivative, was one of the strongest re-uptake inhibitors and releasers of the three monoamines. The tryptamine derivative, 5-methoxy-α-methyltryptamine (5-MeO-AMT), also strongly inhibited re-uptake and increased the release of the three monoamines. N,Ndipropyltryptamine (DPT), 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), 5- methoxy-N,N-methylisopropyltryptamine (5-MeO-MIPT), and 5-methoxy-N,Ndimethyltryptamine (5-MeO-DMT) inhibited monoamine re-uptake, but had a few effects on monoamine release. 1-(3-Chlorophenyl)piperazine (3CPP) and 1-(methoxyphenyl)piperazine (4MPP), which are piperazine derivatives, inhibited monoamine re-uptake and accelerated their release. The results suggest that some designer drugs strongly act on the central nerve system to the same extent as restricted drugs.

The person who originally posted this apparently had access to the full article, and included the researchers' conclusion:

We propose that these drugs be strongly restricted to keep society and its people healthy.

Reputation Comments on this post:

Good find!

[Nagognog2]

Excellent find. This backs many of my findings perfectly. Please post the full article - anyone - if you can find it.

[Alfa]

That article is hard to find, but would be very nice to have.

[nanobrain]

as if there was any doubt, eh gang?

[Rush]

yeah, finally i see some pharmachology research about 5-meo-amt!

how to find old articles that are not online? is there some way? at least abstract because there isnt even that!

i'm interested in
Synthesis and some pharmacological properties of alpha-methyltryptamine and its 5-methoxy derivative.

TERZIAN AG
SAFRASBEKIAN RR
SUKASIAN RS
TATEVOSIAN GT

and also very important to me:
Kantor RE, Dudlettes SD, Shulgin AT.

5-methoxy-alpha-methyltryptamine (alphs, o-dimethylserotonin), a hallucinogenic homolog of serotonin.
Biol Psychiatry. 1980 Apr;15(2):349-52. No abstract available.
PMID: 7417623 [PubMed - indexed for MEDLINE]

thank you for every help!

[Alfa]

You can request articles here: Help from people with Medline access requested

[London_Bloke]

Good find - I'd really like to see the whole thing...

[NeonCortex]

It's uploaded under "Research Chemicals".

Reputation Comments on this post:

	Great find with that article
	points for your posting the PDF
	Brilliant find. Very interesting document.

[radiometer]

You've got me excited! But I'm a dolt and can't find it - can you please link to it? Thanks.

[Alfa]

I just approved it. Most interesting: Research Chemicals

[El Calico Loco]

Pardon my amateurness, but I want to make sure I understand:

The 2C's are mild dopamine, serotonin, and norepinephrine releasers and reuptake imhibitors, while 5-MeO-DMT is a weak releaser but a somewhat stronger reuptake inhibitor?

Do MAOIs work the same way? I thought (for whatever reason) that the action of MAOIs took place in the GI tract rather than the brain, preventing things from getting digested properly (or causing other things to get digested the way you want them to).

I suppose this says something about the use of tobacco and DXM with these RC's...tobacco smoke inhibits the reputake of dopamine, IIRC. DXM supposedly inhibits both dopamine and serotonin.


ECL

[Alfa]

MAOI's are something different but related. MAOI's inhibit the oxidating of the mono amines mentioned above(dopamine, serotonin, and norepinephrine). In other words: MAOI's potentiate mono amines.
And yes, mono amines are present in the GI tract. But mono amines are not limited to the Brain.

[pankreeas]

so by potentiating do you mean maoi's aid in getting mono amines across the blood/brain barrier at a faster rate? and this is a negative thing?

[Alfa]

I mean that where part of the available mono amines would normally be oxidated, with the activity of MAOI's less mono amines get oxidated and thus more mono amines can affect the body.

[El Calico Loco]

So...5-MeO-AMT strongly inhibits reuptake while encouraging release at the same time. Could this be why some people have such an adverse reaction to it? Self-induced serotonin syndrome, perhaps? While others who have too little serotonin to begin with (naturally, or because they've been using too many drugs lately) have no such reaction?


ECL