Codeine Potentiators

[darkglobe]

*has no idea* .... Search Engine, maybe?

First off you need to determine what "other stuff" is actually in these tablets. I will take this opportunity to remind all drugs-forum users to thoroughly check what the active ingredients in their drugs are. Example: 10-12mg instantly tells me that you really don't know much about the tablets.

Your second task is (once you've found out exactly what they contain) to decide upon a method of Codeine extraction. 10-12mg of Codeine is not a great deal, but if a Cold Water Extraction (CWE, described in other threads) is performed - provided the tablets contain only paracetamol/Acetaminophen and codeine - then you could realistically increase the amount of Codeine you use.

In short: Find out what's in the tablets, learn how to accurately and safely perform a CWE, decide how bad your pain is and take the relevant Codeine dosage.

For painkilling purposes, around 60mg would probably be sufficient.

As far as getting the most out of them, CWE is your best option. I don't really believe in many of the codeine potentiators. If you believe in any, it's important to remember that the placebo effect is still an effect

I know this post isn't the most informative, but users should use the forum search engine and re-read other threads.

Hope it helped, though.

~Dark

[allyourbase]

grapefruit juice has an adverse effect on codeine. benzodiazapines are ineffective potentiators in SWIM's experience, they tend to swallow the experience whole. antacids work wonders by killing off some of the straight acids in your stomach and leaving the digestion of the drug up to enzymatic processes. its not so much a potentiator as it lengthens the experience.

[darkglobe]

Originally Posted by allyourbase

grapefruit juice has an adverse effect on codeine. benzodiazapines are ineffective potentiators in SWIM's experience, they tend to swallow the experience whole. antacids work wonders by killing off some of the straight acids in your stomach and leaving the digestion of the drug up to enzymatic processes. its not so much a potentiator as it lengthens the experience.

Thanks, allyourbase!

I've read conflicting reports on grapefruit juice, and I believe it to be pretty neutral. Many swear by it - go for it! The placebo effect is still an effect, after all.

As far as benzos go, my old mate SWIM tells me they made the experience stronger, and as such he considers them potentiators. I understand that for some the change in nature of the experience may be too great, and would constitute a waste of time.

With regards to antacids... I didn't know that! I'll tell SWIM, he'll be thrilled.

Again thanks for the help. I and SWIM both appreciate it

~Dark

[tryptamaster]

Swim has heard that promethazine doubles the amount of codeine turned into morphine, is tis true?

[fiveleggedrat]

Well, Swim had some the other day with a bunch of codeine, and it did not make a big difference. Def.not 2x more morphine in the body though.

Helped more with nausea than anything.

[Tortoise]

Originally Posted by tryptamaster

Swim has heard that promethazine doubles the amount of codeine turned into morphine, is tis true?

No way. Swim finds that it adds to sedation and removes itchiness and nausea, making the high even nicer, but he has never gotten 'higher' from it.

[darkglobe]

Originally Posted by Tortoise

No way. Swim finds that it adds to sedation and removes itchiness and nausea, making the high even nicer, but he has never gotten 'higher' from it.

There's a ceiling as to how "high" one can get from Codeine alone. Potentiators do not always increase the high, the majority will add other complimentary effects.
Some, of course, will increase conversion and whatnot, thus making one "higher".

And fuck me this thread is still going? Lol.

[flipper70]

Just wondering - swim read a post saying that antihistamines helped codeine effect - swim was just looking at ingredients in propain and they contain Diphenhydramine (antihistamine )as well as codeine and caffeine. can any swiys tell swim if this is a good combo? want to cwe so will the histamine be taken out anyway?

[Ethyl]

Originally Posted by allyourbase

grapefruit juice has an adverse effect on codeine. benzodiazapines are ineffective potentiators in SWIM's experience, they tend to swallow the experience whole. antacids work wonders by killing off some of the straight acids in your stomach and leaving the digestion of the drug up to enzymatic processes. its not so much a potentiator as it lengthens the experience.

You have my ideas too..
When noding really hard on opiates SWIM gets extreme pleasure and can't even relax completly sometimes because of that rush of euphoria, noding isn't just a sleepy nod, it's a rush of dopamine, that's why you can't sleep when you are noding really hard. Benzos block that pleasure, by reducing dopamine leves thru GABA system... BENZO'S INCREASE THE SEDATION, BUT DECREASE THE EUPHORIA.
Do not mistake increased sedation as a potentiator cause in the benzo case it isn't, they decrease euphoria..

[SuprSonik]

Originally Posted by Ethyl

You have my ideas too..
When noding really hard on opiates SWIM gets extreme pleasure and can't even relax completly sometimes because of that rush of euphoria, noding isn't just a sleepy nod, it's a rush of dopamine, that's why you can't sleep when you are noding really hard. Benzos block that pleasure, by reducing dopamine leves thru GABA system... BENZO'S INCREASE THE SEDATION, BUT DECREASE THE EUPHORIA.
Do not mistake increased sedation as a potentiator cause in the benzo case it isn't, they decrease euphoria..

SWIM has tried doses of around 200-250mg codeine with theraputic (5-10mg) amounts of diazepam (Valium) and did not find the experience to be very enjoyable. As SWIY said, it simply increased the sedative effects. However, SWIM also tried similar amounts of codeine with a theraputic amount of clonazepam (Klonopin) and did notice a marked increase in euphoria without any additional sedation. SWIM does not find clonazepam by itself to be nearly as sedating as other benzos, so this makes sense.

It may be worth a try for others who do not find clonazepam's effects to be sedating.

[erriksen]

For what it's worth, SWIM thought he'd mention neither grapefruit juice or calcium carbonate have had any noticeable potentiating effect. Drinking strong tea (not Turkish, just the ordinary kind) seems to heighten the high somewhat, but it isn't really significant and is probably psychological.
SWIM has been looking out for Turkish tea in the shops recently but hasn't found any, but would be happy to give it a go.

[Ethyl]

Try this http://www.drugs-forum.com/forum/showthread.php?t=32135

[0utrider]

I dunno if that has been postet here already, but i found a list.. The stuff thats under "induktoren" (inductors) gets medicine/opiates OUT of your brain, the "inhibitoren" (inhibitors) does make the effects stronger (since it blocks the PGP-pump, but not sure about the english word for that)

take care, if you wanna do any experiments, since some of that stuff could be dangerous. i have made good experiences with grapefruit/orange juice (grapefruit is stronger) and with loperamid. another good potentiator is DXM(dextrometorphan), which might also be used (both in low dosage) to treat withdrawal symptoms.

[0utrider]

sry.. left that out: the title of that list is "major substrates, inhibitors and inductors of the P-glykoprotein (PGP)"

[Codehead]

I find alcohol + codeine combo very enjoyable. Codeine takes all the bad effect away from alcohol, it feels like codeine work about 150% better.

[Tortoise]

Originally Posted by Codehead

I find alcohol + codeine combo very enjoyable. Codeine takes all the bad effect away from alcohol, it feels like codeine work about 150% better.

That's interesting because Swim finds that alcohol takes away from the subtle opiate high of codeine.

[0utrider]

the same here.. i hate alc+opiates/opioides.. it makes the alcohol buzz a little better, but the effects of the opioid itself are close to none. and since i like them better than the alcohol buzz, theres no point of mixing it with alcohol. and its dangerous as well..

i dont think that downers, especiialy benzos, ina low dose are too dangerous or actually dangerous at all, ones gotta be careful though, gotta know what one is doing.

tortoise is right, we are talking of 30-60mg of dxm, not more, not enough to make the dxm effects work for themselves. they will improve the high of the other opioid (just like loperamid)! and if you're worried about what you've written, you dont have to take them right with the main substance but maybe like an hour later or so..
it also work really well against w/d symptoms, if you feel really shitty and youre close to taking opioids again, try one or two dxms, they'll make you feel better without the (unwanted) buzz..

[Tortoise]

Swim's lab rat tried using DXM (45mg) about 30minutes before 200mg codeine (his lab-rat has amazing tolerance) and had a very, very nice time. He isn't sure if there was any potentiaion, but it seems quite likely. There most certainly was no loss of effect though, worse case scenario; it made no difference a all.

[Codehead]

How about 1mg alprazolam (xanax, xanor, etc) and 80mg codeine (my normal codeine dose is 160mg and normal/therapeutic alprazolam dose is 0,5mg). I donät have more codeine, so maybe doubling the benzoid dose will help? Also maybe some alcohol boost?

[SanPerro]

you can also try drinking like half a liter of tonic water, the quinine will make more of the cod demethylize into morphine...

and after half a water you can drink or eat a grapefruit...but i don't recommend it very much..

take an antihistamine tablet too, just to be safe..have a codified day

[darkglobe]

Hmm. SWIM's not been experimenting with codeine lately, but nevermind.

Soon I shall be posting some research I've done (i.e. compiling other people's research), and I will update this thread with what I've learnt over the last few months.

To Outriderx, thanks for the table you posted. I'm not certain of it's accuracy, but it looks about right. I've not heard of a PGP-Pump, but remember it's Cytochrome P450 (I think, it's been a while!) that we're talking about here.

[darkglobe]

Reason for double-posting: To make all readers aware of the many many many mistakes I've made while googling for info on Codeine pharmacology.

In fact, I'm going to ask that this thread and the "Codeine-->Morphine conversion" threads are either deleted or that somebody checks my facts.

[fiveleggedrat]

Swim has been experimenting with quercetin and lorazepam, but believes there is relevancy between experimenting with quercetin and opiates.

Quercetin is, from Swim's knowledge, a proton pump inhibitor, a la bergamottin, an active flavanoid in grapefruit juice.

Swim has enough codeine for two doses. Swim will do with and without the quercetin, and get back here.


EDIT: Quercetin does NOT work, it hurts the codeine from processing.

[Razorbladekiss]

Swim was under the impression chocolate was a good potentiator.
Although he has no evidence to support this, He does eat some chocolate during his sessions. While he cannot confirm or deny any difference he believes its because he was only taking 120-130mg of Codeine

[davestate]

Originally Posted by Razorbladekiss

Swim was under the impression chocolate was a good potentiator.
Although he has no evidence to support this, He does eat some chocolate during his sessions. While he cannot confirm or deny any difference he believes its because he was only taking 120-130mg of Codeine

Natural endorphin release from eating chocolate? Possible, chocolate does make you fell fucking good, especially really really good stuff.