Could somebody explain what this means?: d-amphetamine sensitization abstract

[Sloop]

I know the following abstract is for rats and not humans, but if it did apply to humans does it mean taking gingko with d-amphetamine is a good thing or bad thing?

I cant seem to get my head around what the fuck it could mean, that is if it turns out it applies to people as well?
Could somebody decipher it into street English for me please?

Ginkgo biloba extract EGb761 reduces the development of amphetamine-induced behavioral sensitization : effects on hippocampal type II corticosteroid receptorsAuthor(s)

TROVERO F. (1) ; BROCHET D. (1) ; TASSIN J.-P. (2) ; DRIEU K. (3) ;
Abstract

Pretreatment of rats with the extract of Ginkgo biloba termed EGb761 reduced the behavioral sensitization induced by successive D-amphetamine administrations (0.5 mg/kg) as estimated by increasing values of locomotor activity. EGb761 pretreatment also prevented the reduced density of [[3]H]dexamethasone binding sites in the dentate gyrus and the CA1 hippocampal regions of D-amphetamine treated animals. These observations suggest that EGb761, by reducing glucocorticoid levels, could modulate the activity of the neuronal systems involved in the expression of the behavioral sensitization.

[dmraver]

The short answer to this is that the sensitization studies mentioned in the article probably are not relevent to human (ab)use of stimulants, including adderall (amphetamine).

Sensitization is a well-documented phenomenon wherein successive doeses of a drug (such as amphetamine) produce larger effects over time. In other words, it is a kind of 'reverse-tolerance' effect. Sensitization is an active area of research in the field of addiction because it plays a crucial role in the 'incentive-sensitization' model of addiction proposed by Robinson et al.

While many users may see an 'advantage' to sensitization, the fact of the matter is that it requires highly controlled procedures to be induced (especially time between administrations). Additionally, there is substantial genetic variability regarding individual propensity towards senstization.

Bottom line, while interesting academically, sensitization is probably not practically useful to human drug users.

If you are anyone else wants a more detailed expanation of sensitization, I would be more than happy to provide it. Hope this helps.