Tfmpp

[Rush]

was wondering:
if mCPP is not neurotoxic, TFMPP is also non-neurotoxic?

and is true that mCPP causes anxiety and TFMPP dont?

[Thirdedge]

Well Swim can not answer your question on specific neurotoxicity, however swim would say there is definetly 'less' anxiety with tfmpp, but it is still present.
mCPP was used to invoke migrains in test subjects and certainly feels like a dirtier chemical in swims experience. It would seem approximatly 1 in 10 enjoy mCPP (most likely the vendors) while the other 9 spend several hours in toxic hell.

[Rush]

thank you for the answer...

i searched around infos about TFMPP...but i cant find reports of TFMPP alone!
always with BZP!

what does TFMPP alone?somebody knows?

[Psych0naut]

For SWIM mCPP definately didn't cause anxiety, more the opposite. He was imitating animal sounds in the city center while on it ..

[PhilliusBoro]

I find this very interesting as SWIM snorted several lines of tfmpp after a night on bzp/tfmpp pills and was trotting round the flat pretending to be a horse, neighing and everything.

The effect was almost delirium. It made SWIM feel most woozy the next day though.

Tfmpp on its own has little to no effect. but after some bzp/tfmpp/a mixture, it can be very potent.

[Cuberun]

swim didn't experience anything notable on tfmpp on it's own. not worth it. he didn't like bzp mixed with tfmpp either.. it seemed to emulate negative effects of mdma (double vision and confusion) without adding anything positive.

bzp on it's own is doable, TFMPP though doesn't seem worthwhile added or on its own. Tt's as if tfmpp is only added to make bzp a more realistic "ecstasy" experience...

[~lostgurl~]

SWIM found Frenzys which are mainly BZP to be like amphetamine but with no euphoria so no good buzz or anything.

Exodus which are BZP and TFMPP started out fantastic, like a really good E, but after an hour it turned into what felt like a horrible acid trip.

SWIM stopped experimenting with legal party pills after that. SWIM never tried TFMPP on its own - to her knowledge, though she had tried a few other legal party pills before these experiences with no real effects.

[waxhorse]

Waaaay back when, when tfmpp was pretty freely available, Swims monkey ate it at doses of about 50 and 100 migs.

I remember my primate communicating in sign language that there is a very trippy effect from the stuff at higher doses. Very strange stuff!

Somatic effects are also there and not very pleasant at all. There was this sort of intense sunburn feeling on the skin that wasn't pleasant and the headache the next day was simply splendid!! (And of course, nausea.)

I believe that many would call it "Toxic."

WH

[nozty]

oh yah and btw is there a way to prevent the chilling feeling of tfmpp?

-glad to be part of the comunity... =)

[Rush]

after some swim's further experiments with tfmpp, swim noticed some new things:

the experience comes and goes like waves(stimulation+hot feeling, then sedation+chills)

swim's chills occurs right after drinking fresh water. I think tfmpp makes the brain more sensitive to temperature changes...

another thing, i confirm my first post: tfmpp is anxiogenic.
it made swim an anxious feeling the days after.
maybe there is anxiety-effect even in the experience itself, but it is covered by the pleasure and the emphatia.the next day only anxiety(5-ht overstimulation?) is left.


maybe, an anxiolitic drug for the comedown can make tfmpp something better.

some articles about it:

Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze: profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP

ABSTRACT

It has recently been proposed that the "serenic" (antiaggressive) agents, fluprazine and eltoprazine, may enhance fear/anxiety reactions in laboratory rodents. In the present study, the influence of these compounds (1.25-10.0mg/kg) on anxiety-related behaviour in male mice was examined in the elevated plus-maze test. For comparative purposes, the effects of 8-OH-DPAT (0.01-1.0mg/kg) CGS 12066B (1.25-10mg/kg), TFMPP (0.63-5.0mg/kg) and mCPP (0.5-4.0mg/kg) were also assessed. Behavioural analysis incorporated not only traditional parameters but also several novel measures of defensive behaviour (i.e. "risk assessment"). The selective 5-HT(1A) agonist 8-OH-DPAT produced effects only at 1.0mg/kg, with evidence of an anxiolytic/sedative action at this dose. In the absence of other behavioural changes, CGS 12066B (a selective 5-HT(1B) agonist) caused a preferential and dose-dependent (2.5-10.0mg/kg) stimulation of closed arm entries, an effect also seen with low doses of TFMPP (0.63mg/kg) and the serenics (1.25-2.5mg/kg). In addition, both TFMPP and mCPP (5-HT(1C/1B) agonists) induced dose dependent anxiogenic-like effects over the dose ranges tested, with the most pronounced changes observed on measures of risk assessment. The profiles of fluprazine and eltoprazine on plus-maze behaviour were not only similar to one another but, on most parameters, were also remarkably like those observed with TFMPP and mCPP. These data question the behavioural selectivity of the serenics and further support the proposal that these compounds may potentiate anxiety. Findings are discussed in relation to underlying receptor mechanisms, and the utility of a more ethological approach to the analysis of behaviour on the elevated plus-maze.

Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice

Summary 8-OH-DPAT (2.5–10 mg/kg) and buspirone (10 mg/kg) but not 5,7DHT (200 g/mouse), pCPA (75 and 150 mg/kg, three times), ritanserin (0.1 and 0.2 mg/kg), LY 53857 (1.5 and 3 mg/kg), GR 38032 F (0.1–100 g/kg), TFMPP (5 and 20 mg/kg) and mCPP (2.5 and 5 mg/kg) antagonized the rise in body temperature that occurs to the last mice removed from their group housing, which was termed as stress-induced hyperthermia (SIH). Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirione. Instead, when cerebral 5-HT content was reduced to 50% by 5,7-DHT-induced lesion, the effect of buspirone on SIH was decreased. TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/kg did not modify the pattern of SIH at all. The lower dose of TFMPP evoked a hyperthermic and the higher a hypothermic response.

[Rush]

Here are some new considerations about tfmpp:

TFMPP isnt neurotoxic: swim didnt experience a serotonin depletion or depression the days after.

however, the bad side of tfmpp is the experience itself.lot of physical troubles, and temperature changes, there is some happy feeling(empathogen,), mixed with anxiety.the down was also unpleasant, with nausea,vomiting and headache.

low doses(15-25 mg) made swim stimulated and happy.amplifies emotions, but producing a bit of anxiety.
high doses(50mg+) made swim sick.

so, my advice is to stay away from it.