5-meo-amt pharmacology?

[Rush]

somebody know its pharmacology?
how it works in the brain?

how is related to amphetamines?

thank you!

[Alfa]

It's a tryptamine, not an amphetamine. Different category, different effects.

[Rush]

) ok, now that, but:

from AMT erowid basics:
DESCRIPTION
AMT is a psychedelic amphetamine-tryptamine first developed in the 1960's for anti-depressant research

and, from AMT faq:

What is AMT?
AMT stands for Alpha-methyltryptamine. AMT is the indole analog of amphetamine, which accounts for it's stimulant properties

ok,i know, we're talking about 5meoAMT, but right now i cant find where exactly i read that thing, but i found about AMT that is closely related

what means "indole analog of amphetamine"?

[Nagognog2]

It means that at the 3- position on the indole nucleus there is: CH2CHNH2CH3 group. This is the same as is found on the amphetamine molecule where instead of an indole nucleus, we have a phenyl group. In this way it is the "amphetamine analogue" of indole.

In the case of 5-methoxy -alpha - methyltryptamine there is a CH3O grouping at the 5- position on the indole nucleus.

5-MeO - a-MT is considered by most to be a horrible experience with effects such as nausea, vomiting, loose bowels, headache, tremors, muscle cramps - yuck!

[Rush]

thank you for your answer...

however i would like to find other infos about this RC.

how can i find the medical researches, like those some other user posted around?

thank you!

[Iggypoop]

www.pubmed.com is a good place for journal articles but most of these compounds have little or no research done on them.

www.maps.org has a 'psychedelic bibliography' of studies which have been done on many compounds.

www.heffter.org also has a selection of resources.

5-meo-amt has many critics, although each person is looking for different things from their experience. Many people feel queasy without the 'bowel loosening' effects.

YMMV (your mileage may vary)

[Rush]

damn...cant find nothing about it!

however...is here someone that knows something about drugs(tryptamines) and pharmacology?maybe we can make some ipothesis!

my ipothesis is that 5meo-amt is a very strong,full, serotonin agonist, unselective(every receptor),and maybe, more agonist than serotonin itself is(if this can be)

the effects of initial nausea its probably because oral administration does stimulate serotonin receptors in the stomach, thus giving nausea(that fades away when 5meo-amt goes into blood and brain).

when 5meo-amt is in brain is a pure serotonin syndrome.
in fact syndrome syntoms are:

Cognitive effects: mental confusion, hypomania, hallucinations, agitation, headache
Autonomic effects: shivering, sweating, fever, hypertension, tachycardia, nausea, diarrhea
Somatic effects: myoclonus/clonus (muscle twitching), hyperreflexia, tremor.
Insomnia, sleep disruption, and unrefreshing sleep are also reported symptoms, as well as itching and hives.

also i noticed highly empathogen effects, extreme mood lift&wellbeing feeling energy(after nausea and before headache)

also, because headache occurs after 6-9 hours, i think it is probably due some kind of metabolite of 5meo-amt, or extreme fatigue due over-stimulation of neuro receptors

i see most people who disliked the experience tried doses of 5mg and more.this is wrong in my opinion because high doses(and even 4mg is high for 5-meo-amt) gives more bad effects.right doses are from 0.5mg to 3mg.this makes also little or no side effects & hangover.also the hangover is quite strange:the day after you'll feel exausted, but for the next days you can be quite hyperactive

also this substance leads a mild psychological addiction(probably due the downregulation of serotonin receptors after overstimulation) with regular use, syntoms anxiety and insomnia(amphetamine like), but this fades away in 1 week

the thing that I don't know is if this substance also interfers with dopamine system, like somebody here around posted, or if other than agonism action, it also have a releaser and reuptake inhibitor action

[Alfa]

You can also request articles about 5-meo-amt here: Help from people with Medline access requested
Found articles will then be posted in the Tryptamines section of the file archive.

Other resources:
5-MeO-AMT Effects and Ratings Survey Results
5-meo-amt + nausea
5-MeO-AMT experience
5-MeO-AMT Dosing
The 5-MEO-AMT Metathread