Combining MDMA with Strong opiates

[Fantasian]

Once again i ask a question on combining MDMA with something.

Can MDMA be safely combined with a strong opiate such as buprenorphine or Morphine. SWIF's Friend Albert has a very severe wrist injury that is in the process of healing, he is prescribed 10mg of morphine per day that he takes at 8pm. He wondered whether he would be able to then take MDMA at around 11pm and have a good night.

SWIF has heard that some people take MDMA in order to get the lucidity of life back when on opiates regularly. What are the dangers and possible effects of combining these two on a night out?

Reputation Comments on this post:

very intriguing question and most helpful for some...

[Forthesevenlakes]

SWIM's done some trials where oxycodone 40 mg was taken a couple hours before a roll. The roll proceeded fairly regularly, and seemed to overpower the normal opiate buzz. SWIM has never taken them at the same time, but 3 hours seems like enough space between the two to be fine, especially given the relatively small dose.

Unless theres some kind of bizarre pharmacology that SWIM doesnt know about, he'd say theres not much danger in taking MDMA in the same night as long as one didn't try to push the doses of either drug too high. Maybe wait back to hear a few other answers before giving Albert the go-ahead though...

[Nagognog2]

Back before that bleak day for psychotherapuetic efforts here in the USA when the Feds outlawed MDMA, MDMA was given to people with terminal cancer. These people were also commonly using large amounts of prescribed opiates for intractable pain. There were no reports of any negative drug interactions.

[radiometer]

Aren't some opiods/ates serotonergic at higher doses? I vaguely remember reading some sort of warning of increased risk of serotonin syndrome in some cases.

[Forthesevenlakes]

Tramadol has some SSRI properties. That's all SWIM can think of for the time being.

[Nagognog2]

Tramadol is not a true opiate. It does indeed act as a SSRI and is best avoided - especially in combination with other drugs which affect serotonin. It would likely block the entactogenic effects of MDMA. As it does with methylone.

[Nature Boy]

In regards to effects, an MDMA/opiate combination might be an ultimate high like a cocaine/heroin speedball. Of course there are risks involved in regards to heart rate but if undertaken extremely carefully it could work. However in SWIY's situation, both drugs will not be taken anywhere near the same time. The risks would be lowered significantly.

[Psych0naut]

As mentioned by Nature Boy, the only risk would probaply, just like with a speed ball, that one's respiration might be stimulated by the MDMA, but when it wares off and the opiate still has a strong effect, that ones respiration might be supressed.

[primal440]

SWIM has taken once a combination of Morphine Sulphate 10 mg IV and around 120 mgs of MDMA oral in one night, spaced out for approx. 3 hours between them, just like in your friend's circumstances. I dont know if this will much of use now for your friend but anyhow, as far as SWIM could tell there was no significant difference or bizzare bad/unwanted synergistic reaction between both. Morphine acted as it should, slightly shallow breathing, complete body relaxation, the usual if your acquainted with morphine or other strong opiate's effects. Keep in mind that for some users, opiate naive or with low tolerance in general 10 mg is sometimes a big dose and these side effects may be much more marked, in this case SWIM is just an opiate hard-head.
Anyhow, around 2 hours and 3 after IVing he swallowed the MDMA and as soon as he could feel it take effect he actually felt his body was going easier than it was going with morphine, breathing was nt so shallow anymore but still relaxed (something to do with MDxx's antiasthmatic properties probably?), he didnt notice any abnormal response from his heart like arrythmia, but he did feel that during the MDMA come-up his heart started pounding faster than it was but it latter settled on a regular beat. He felt his chest very much cleansed and more light, compared to the constriction feeling he sometimes get with morphine. Also the head pressure was greatly alleviated. That's it for physical effects as I can't recall more from SWIM's experience right now.

As for the subjective experience I would say this combo is in the pantheon of drug mixtures for SWIM, a combination of both dopamine and serotonin tweakage gave the ultimate pleasure for him, very very synergistic (in a good way of course), it was like combinining this very old and ancient feeling of well-being, easyness and general happiness that opiates give with the emotional brush from the MDMA that gave more content and insight to the high and permitted to evolve magically, the ultimate reconciliation, with whom I dont really know right now. There was no noted serotonin-syndrome effects as radiometer suggested but who knows, this may not be the case with higher doses. And as Natureboy was saying, this migh as well be THE ultimate high for SWIM, although he's never speedballed and probably never will he can't imagine how that beast would win over this one animal (more gentle probably, it was for SWIM). To me dopamine + serotonin is better than dopamine + dopamine although of course, this is speaking very roughly as there's an almost infinite number of complications within the human brain but I think that the affirmation still holds in a very simple way. Another thing to add, I know there's a lot of members over here that dislike very much the drug Tramadol (I can think of especially one), but SWIM loves it with all his heart and considered this combo to be like the mother and tramadol the children or fetus, whatever, the thing is that it felt for SWIM as this was a higher higher level of Tramadol goodness (which also holds by itself this dopamine-serotonin combination in its effcts on SWIM's body, although mechanically different as most of you must know); of course, this level of pleasure cannot be achieved or emulated with only Tramadol but it was just to give an idea.

If anybody wants more insight into the subjective experience of SWIM I'll tell him and see. I dont think your buddy is gonna have any problems, especially if he's injured and probably already has developed some tolerance to Morphine.

[Micklemouse]

Originally Posted by radiometer

Aren't some opiods/ates serotonergic at higher doses? I vaguely remember reading some sort of warning of increased risk of serotonin syndrome in some cases.

There have been reports of serotonin syndrome from SSRI's combined with opiates

http://www.drugs-forum.com/forum/sho...67&postcount=2

so there is possible cause for concern when combining serotonergenics & opiatess/opioids, although it seems to be mainly the synthetics that are problematic so far - tramadol, pethidine,etc.

[Fantasian]

Just to update all, SWIF and his friend Albert had a great time. The only thing ALbert wanted to note was that the urinary rentention sometimes experienced with his opiate dosages was increased significantly so that it took him over 24 hours to take a piss. This however rectified itself with time.

Thanks for the advice again guys.

[Sklander]

Thanks for this thread. SWIM is about to venture into this fun maze.

***REPORT***

SWIM ingested 100MG Morphine then took a capsule with supposed MDMA in it. Route for method of ingestion was rectal. The experiment could not have gone any better. SWIM is sitting on his bed melting into it. He is playing Tool and is enjoying it very much. Surprisingly, the Morphine did not hinder the upper experience of the MDMA.

Highly suggested by test animals.