and norepinephrine to leak out of their storage vesicles and into the synaptic cleft. To a lesser extent, methamphetamine inhibits the DAT (dopamine transporter) that is responsible for the reuptake of the neurotransmitter
back into the axon; simply put, it is a dopamine reuptake inhibitor (but to a lesser extent than methylphenidate
). Methamphetamine also inhibits monoamine
oxadise to a small degree, which prevents the dopamine and norepinephrine from being deactivated in the synapse. These three pharmacological actions cause the dopamine and norepinephrine to remain in the synaptic cleft for much longer than normal, and thus stimulates their respected receptors for a longer period of time than normal. The main euphoric qualities of methamphetamine are believed to be the release of dopamine in the nucleus accumbens shell as well as the core. Since endorphins indirectly affect this part of the brain, I can see how one would conclude that methamphetamine releases endorphins. But it's just not true because it is not a ligand for any subtype of opioid
receptor (mu, kappa, delta, omega).