Experiences - MDPV Experience Report(s)

[magicmik]

Swim's freind is good at acquiring a good mix of chemicals. Swim bought 30mg of this new compound. Then swim read your reports. This put swim off for a while.

However, swim finally tried 7.5mg (half of what swim's freind suggests) nassaly (no fancy gadgets, just a note), 2 little lines.

Swim can understand what people mean about redosing but swim was very pleasently suprised .

6-hours of a v nice experience. 45-mins to come-up, lots of energy,v talkative; swim went for a long walk with his little swimmy.

After the walk swim felt pleasure like a subtle mixture of C and mdma with the physical effects of speed.

Then a gradual tappering off of effects with no noticable comedown.

Swim used the same amount for the next 3 weekends with no noticable problems or loss of effetcs.

What swim wants to know is can this stuff be smoked?

Reputation Comments on this post:

Thanks for sharing.

[fastandbulbous]

SWIG is also very compulsive with this stuff.
He feels a need to redose every couple hours (if smoking he sometimes redoses every 45 minutes or so).
The strange thing is that SWIG doesnt find this substance enjoyable at all. It makes him less sociable, scatter brained, does not help much with studying and makes him feel depressed. And still he redoses the stuff like a fiend.

And I think therein lies the problem... once you go over a certain amount in a fixed time period (the amount in say one day differs from person to person), then it suddenly loses it's most desirable properties and produces a 'cracked out' feeling with excessive sympathetic activity. Redosing every 45 mins will almost inevitably lead to this state; I've found no less than 4 hours between redoses and no more than 30mg in a 24 hour period (rectally) to be the ideal limit for a dosage regieme.

[Nicaine]

Originally Posted by fastandbulbous

And I think therein lies the problem... once you go over a certain amount in a fixed time period (the amount in say one day differs from person to person), then it suddenly loses it's most desirable properties and produces a 'cracked out' feeling with excessive sympathetic activity. Redosing every 45 mins will almost inevitably lead to this state; I've found no less than 4 hours between redoses and no more than 30mg in a 24 hour period (rectally) to be the ideal limit for a dosage regieme.

30mg in a 24 hour period rectally!! SWIM can't take more than about 3-4 mg per rectal dose, and the notion of 7 to 10 redoses in 24 hours is just too much. He finds 4mg rectal equating to 10-15mg via snorting or oral routes.

SWIM has his own dosing regimen, using a nasal atomizer (i.e. snorting MDPV dissolved in dh2o). Snort ~0.5mg, wait 15 minutes, snort ~0.5mg, wait 15 minutes, so on and so forth. Eliminates the whole "number of redoses" controversy and keeps his blood levels a lot steadier. ISE it's those brief ups & dizzyingly fast comedowns that makes MDPV a frustrating/annoying substance, so SWIM does what he can to keep the high on a fairly even keel.

SWIM ordered another 100mg for his monkeys last night. The combination with propylhexedrine was outstanding, resembling methamphetamine in every aspect (including length of effects, 12+ hours up there followed by a very gradual comedown). It was almost too much... if/when SWIM does it again, he'll be sure to start in the MORNING so he can sleep some time during the following night. Even high dose benzos didn't bring him down much off that combo... it was POTENT. He'd be more than a bit worried if one of those 'panic attacks' struck while he was tweaking out on both substances.

[Nicaine]

SWIM has noticed a lot of influence from 'mental attitude' on the enjoyability of MDPV. Someone in another thread noticed a strong, irresistable 'energy push' at higher doses, and SWIM has noticed this as well. Earlier he caught himself thinking "wish I could relax, this sucks, I want to come down." Needless to say, it DID suck. Later he started thinking "energy.... energy... this rules" and the high was a lot better. Guess this goes for any substance, even psychedelics... if you don't like the head space, it's gonna suck. SWIM thinks this substance could actually help get him off his arse & out doing interesting stuff for the first time in years, provided he's willing to give up the comfort zone he's gotten so fond of.

[nanobrain]

it is the others' comfort levels that get stretched with the given monkey under MDPV. careful.

[Nicaine]

Originally Posted by nanobrain

it is the others' comfort levels that get stretched with the given monkey under MDPV. careful.

SWIM thinks MDPV is deceptive in that it can certainly cause problems if abused, but he doesn't believe it's somehow "special" or more toxic compared to other stimulants such as meth or coke. It has to be equally respected alongside the classic stims... however, SWIM doesn't think it needs more respect than those. Yeah, maybe there are unknown long-term toxicity factors, but it doesn't seem likely given the subjective effects of the drug. Something that digs deep enough to cause permanent damage to dopamine neurons would very likely be inducing strong euphoria, hyperthermia, seizures, mania, hallucinations, psychosis and extreme anhedonia upon comedown. Brain damage doesn't occur in a vacuum. What SWIM has experienced seems more reminiscent of a moderate reuptake inhibitor along the lines of methylphenidate.

[snapper]

Those are dangerous assumptions to make, Nicaine. Chems can damage you through all kinds of mechanisms, and MDPV is new and unknown.
SWIM feels that MDPV is not as friendly as other stims. It is too dose sensitive when it comes to catacholamines. With cocaine or speed, SWIM can push the euphoria way higher with repeated use, but with MDPV, hitting that magic 8mg creates a super unpleasant state of of extreme tachycardia (160-180bpm), sweating, dizziness, numbness of extremities, rapid and weak peripheral pulses with dropped beats, extreme overstimulation, shakes and confusion. This translates to SWIM as 'about to overdose and flop like a fish'. SWIM had this happen twice now, and stopped it quickly with an atenolol and a light dose of a traquilizer SWIM had put away for an emergency. SWIM was fine after that, will all of MDPVs effects gone (SWIM always found propranolol to stop cocaine's high for SWIM too back when SWIM abused it, so go figure...).
Now for an well prepared idiot like SWIM, this is not a big deal. SWIM could recognize and deal with the problem, but this could be deadly to someone else with a higher dose and nothing to control the symptoms with (ie - worse idiot who is not prepared). Now kratom and weed were on board both times and could be contributing factors, kratom as a stimulant and weed as an anticholinergic (increases heartrate), but SWIM has never had this happen with the two latter alone. These reactions have prevented SWIM from pushing MDPV to 10 mg orally, and SWIM is beginning to think that this chem has too short of a duration of effect and is too unpredictable for SWIM to push any further at all.
SWIM supposes that part of the fun is research, but not if it makes SWIM feel like SWIM is about to die.
And no, SWIM is certain that these two episodes were not panic attacks. SWIM was not nervous or had any of the normal thought patterns SWIM has when these occur. In fact, SWIM would not have dealt with them as rationally or quickly had they been.

Reputation Comments on this post:

good advice

[Nicaine]

Originally Posted by snapper

Those are dangerous assumptions to make, Nicaine.

Dangerous how? SWIY should know how careful SWIM is with this stuff, after reading these experience reports. They're educated guesses, that's all. They don't affect SWIM's care in using the substance.

These reactions have prevented SWIM from pushing MDPV to 10 mg orally, and SWIM is beginning to think that this chem has too short of a duration of effect and is too unpredictable for SWIM to push any further at all.

It becomes obvious rather quickly that MDPV is not amenable to being "pushed" in dosage, but SWIM is not at all sure why this suggests it may be a dangerous substance at more reasonable doses. Some drugs work with a "more is better" formula applied, some do not. Acetaminophen is supposedly pretty safe, but "push" its pain relief much and you're six feet under. OTOH, opiate dosages can be "pushed" (within limits) for more relief of pain if the current dose isn't doing it.

FWIW, SWIM has pushed meth doses with much worse results than anything reported for MDPV. Extreme paranoia, inability to tolerate light/sound, high temperature, extreme cardiac effects, feelings of insects crawling on the body, and a "panic attack" along with that. Is meth somehow less dangerous than MDPV, or is it just that familiarity breeds.... ahem, trust?

SWIM supposes that part of the fun is research, but not if it makes SWIM feel like SWIM is about to die.

Good, SWIY is right... it's not worth it. Try combining stuff like SWIM's been doing... kratom is a good combo (although some really bad jitters can occur), propylhexedrine a better one. There are potentially many others.

[snapper]

The reason that I think it is dangerous to assume there are no long term problems with use of ANY chemical is that there are infinite mechanisms for such problems to occur. It could be that MDPV is really good at suppressing the bone marrow long term (like was found to be a side effect of many RX drugs), or perhaps it accumulates in neurons like mptp - > mpp+. My point is not that your assumptions about dopamine receptor depletion are wrong, but that these systems are infinitely more complicated than that, and the recent paultry short term evidence from a few subjective trials is useless as data for long term consequences, or even any meaningful charaterization of short term consequences. Even with FDA scrutiny, they pulled coxibs from the market after they were approved. Chloramphenical, a really useful antibiotic, got pulled from the human medicine market because it destroys the bone marrow of a small proportion of people by no known mechanism after being used for quite a while.
I'm not trying to screw with you, just point out something everyone here should acknowedge.
Tread lightly and don't be cocky.

[snapper]

In response to the rest of your thread, SWIM thinks that kratom may be a contributing factor. Yohimbine is a alpha2 adrenergic antagonist, and as such will take the brakes off of any tachycardia by inhibiting activation of the alpha 2 which would normally decrease heart rate and blood pressure. This would predispose those with high levels of catecholamines to a more rapid heart rate.
Anyways, SWIM is not pushing the dosage to see where it becomes toxic, but in the hope of finding a pleasant effect other than stimulation from this chemical. SWIMs trials have confirmed the fact that this is not available to SWIM without unpleasant side effects. Hence SWIM will abort future trials and be happy that SWIMs monkeys used it up.
Each response is individual.
What is interesting is that even though SWIM finds few redeeming qualities in this molecule, it does have a stong addictive draw. Really reminds SWIM of some of the aspects of cocaine. While SWIM was struggling with the side effects, SWIM still considered redosing as soon as SWIMs heartrate dropped. Bad sign.

[fastandbulbous]

30mg in a 24 hour period rectally!! SWIM can't take more than about 3-4 mg per rectal dose, and the notion of 7 to 10 redoses in 24 hours is just too much. He finds 4mg rectal equating to 10-15mg via snorting or oral routes.

Out of a senso of curiosity and a plain desire to see if it incresed potency, the thought of 'what's it like via IM?' crossed my mind. Full aseptic techniques were followed and 5mg was administered IM (in the upper thigh)...

I have a feeling that I've just opened Pandora's box with regard to MDPV. The euphoria was in the realm of 'fuck me, this is good', to the point that 10 mins after administration I was verging on omnipotent (well that's how I felt!) and my libido went through the roof in that whatever subject I considered, it was eventually linked to sex in one way or another. Then the 'oh fuck' effects kicked in... After about 2 hours the desire to redose was pretty damn strong, which I gave in to. After another 5mg I was a man with a plan (how I'd refer to the effects of something like methamphetamine on motivation & self confidence); I also could have easily, and with no feelings of embarrassment, performed a tour de force role as a porno star (would have had no problem with a display of public copulation, which I'd not consider when sober). After another 90 minutes I once again felt a strong desire to redose, but thought 'put distance between yourself & this drug so you can't redose' so went to a friends. While there the conversation kept returning to the subject of sex (but at leat I didn't redose).

Eventually, after about 4 hours I felt it was OK to go home; knowing the MDPV was nearby at hand did produce twinges to redose, but I did resist the urge, took a small amount of GBL and went to bed. I'm only glad my other half was working a late shift at work as I'm not certain that I wouldn't have tried to screw her to death!

Basically, dosing by this route pushes the euphoria, sex drive & urge to compulsively redose into the realms of cocaine (but without the acting like an arrogant twat that coke produces in me - which is why I avoid coke). Anybody indulging in administration by this route should be aware that both the good & the bad in MDPV increases by an order of magnitude; what IV would be like is something I don't even want to consider (I've never IVed anything and have no intention to ever do so), but if you are considering it, be warned you may start something you cannot later exert any control over (think IV coke administration, but with a clear head/thought patterns).

I thought long and hard as to whether to report this, but part of drug use is being informed and also taking responsibility for your actions, so in the interests of incresing knowledge about this substance I wen't with info dossemination, but you have been warned

Reputation Comments on this post:

	good post
	Self-incrimination, read the rules!
	thx for sharing this experience, was a great read.

[Nicaine]

Hah... SWIM ran out of MDPV this morning. He's got some on the way in the mail, but it was only shipped 3 days ago. Looks like SWIM gets an enforced break from MDPV for part of the week, unless shipping is out-of-the-ordinary fast.

[Psych0naut]

Nicaine, please remember to set limits in advance.Before SWIY takes more MDPV, make a promise to SWIY's self that he will not use more than promised, and stick to that limit later in the future.
Remember what happened with SWIY before, the propylhexedrine use that went out of control? Resist the temptation.
Also think about the fact that both MDPV and propylhexedrine's recreational use aren't well documented, and that not much about it is known yet.
SWIY's lab animal can ofcourse use some substances once in a while, or do some "research" on it by administrating it to your lab animal, but he shurely doesn't want to become a lab animal used for discovering the substance's toxicity limits, let alone the LD50.

[Nagognog2]

Or carcinogenesis and the organs affected...

[Nicaine]

Thanks guys, very wise suggestions. SWIM is on an official break from stimulants, as he suspects he's suffering from malnutrition and possibly a stomach ulcer. Nothing stronger than black tea for awhile. He needs to deal with his use of Ambien as well, although that may be even more difficult (he finds it highly euphoric and compulsive, used up 40 tablets in 10 days). The rest of this month is not going to be much fun .

P.S. SWIM does not think he's suffering from serious dopamine depletion... his sex drive is active (if somewhat diminished), which is a good sign. His use of L-Tyrosine on off days has probably helped a lot.

Also -- Thanks for the report, fastandbulbous. For those who don't want to inject it IM (probably most of us), the options of rectal and smoking are always open. SWIM wonders if someone will eventually get it into freebase form & try smoking it that way. It's probably a big waste smoking the hydrochloride salt.

[Nicaine]

BTW this is a bit off topic, but SWIM's got an idea re: running out of Ambien early -- he has a bunch of Lyrica (pregabalin) kicking around prescribed to him by a zealous doctor who likes giving out the stuff. SWIM has just been letting it pile up.

Check this out (from rxlist.com):

Controlled Substance Class: LYRICA is a Schedule V controlled substance.

In a study of recreational users (N=15) of sedative/hypnotic drugs, including alcohol, Lyrica (450 mg, single dose) received subjective ratings of "good drug effect," "high" and "liking" to a degree that was similar to diazepam (30 mg, single dose).

SWIM has never tried a 450mg single dose of Lyrica, but when his Ambien is gone you can count on it .

[fastandbulbous]

SWIM wonders if someone will eventually get it into freebase form & try smoking it that way. It's probably a big waste smoking the hydrochloride salt.

From what I've heard from others & read about reports, smoking MDPV is not a good idea - it produces levels of compulsion near that of cocaine when taken by that route and is subject to a fair bit of pyrolysis (so you don't know what sort of heat degraded crap you're putting into your lungs). Basically a good way to see a lot of money disappear, behave like one of the fiends in the 1930 anti-cannabis films and end up feeling like warmed up shite with panic attacks.

From trying different routes other than snorting (don't snort anything due to dodgy sinuses) there is a marked difference between oral, rectal and IM. Oral is the least efficient; rectal is much more efficient, but IM is more efficient still(in terms of mgs required for same effect). I've never seen anything about metabolic fate in humans but I have a suspicion that MAO has an important role; gut MAO would have a small effect on the rectal route, but a much larger on on the oral one (and bog all on IM). I suppose an enzyme kinetics study with MAO & MDPV as the substrate would give the answer, but please don't use your body as a testing lab for this one as MDPV & a MAOI just feels like it has all the makings of a disaster (the sort involving hospitals & autopsies).


BTW Nicaine - rectal dosing has very little and IM no effects on the digestive system so I think any activity must be local to the region of the intestine containing the bulk of an MDPV dose (which would indicate that it might cause ulcers if repeatedly dosed, orally)

[Nicaine]

Originally Posted by fastandbulbous

BTW Nicaine - rectal dosing has very little and IM no effects on the digestive system so I think any activity must be local to the region of the intestine containing the bulk of an MDPV dose (which would indicate that it might cause ulcers if repeatedly dosed, orally)

Thanks for the info... SWIM is going to try IM dosing (at least once) when he receives more MDPV. Insulin syringes are legally OTC in his home state, so it's a simple matter. If it results in an actually satisfying MDPV experience, it will be well worth it.

[Nicaine]

SWIM has been off stimulants for 7 days straight. His stomach/intestines are getting back to normal, but yesterday he got tired of staring at the f**king walls, went to see his doc & got a prescription for Effexor XR (SNRI antidepressant).

SWIM attributes the depression to general stimulant over-use + malnutrition (20+ Lbs underweight) and isolating in his apartment, but he also feels MDPV did play a specific role. He never felt quite that much residual depression from other stimulants. This is the first time he turned on his computer in a week.

[snapper]

SWIM found the sour stomach after each use, but also gets this from most other strong stims. SWIM pretreated with vitamins, nootropics, zantac (150mg every 12 hours for 2 doses) and anti-oxidants. SWIM also remembered to eat, which is not that hard with MDPV as opposed to other stimulants.
SWIY should be really careful with combining MDPV with effexor. Effexor is a good antidepressant, but it is also the most addictive (physically) and side-effect ridden SSRI out there. With its reuptake inhibition of norepi as well as serotonin, taking something like MPDV could be really bad. It could also negate the effects, though since MDPV primarily tickled dopamine receptors, it should still work.
Be safe and SWIM hopes SWIY gets well quickly. SWIM used to end up in SWIYs position all the time, but eventually SWIMs body just couldn't handle it anymore and SWIM learned to behave (most of the time...).

[Nicaine]

Originally Posted by snapper

SWIY should be really careful with combining MDPV with effexor. Effexor is a good antidepressant, but it is also the most addictive (physically) and side-effect ridden SSRI out there. With its reuptake inhibition of norepi as well as serotonin, taking something like MPDV could be really bad. It could also negate the effects, though since MDPV primarily tickled dopamine receptors, it should still work.

Agreed. It should be OK on the current low intro dose of Effexor SWIM is taking, but extreme caution is called for at higher doses.

Then again, maybe it'll work out well and prevent the post-high depression many experience from MDPV. Or SWIM will just have to lower his dosage of MDPV a lot to prevent bad side effects from the combo. Either of these options could be beneficial. And of course if he has to stop using MDPV altogether, then so be it. An hour or two high is not worth days of depression in between uses.

Be safe and SWIM hopes SWIY gets well quickly. SWIM used to end up in SWIYs position all the time, but eventually SWIMs body just couldn't handle it anymore and SWIM learned to behave (most of the time...).

SWIM appreciates the well wishes. He is in fact at about the same place as SWIY now... it's either behave, or suffer bigtime (and I mean BIGtime).

[Ximot]

Has anyone on here combined MDPV with any other stimulant or with a 2C or a tryptamine?

[Nicaine]

Originally Posted by Ximot

Has anyone on here combined MDPV with any other stimulant or with a 2C or a tryptamine?

SWIM has combined MDPV with propylhexedrine (a stimulant). Perhaps a bit better than either substance alone, but nothing that remarkable.

[Nicaine]

BTW, SWIM went off the Effexor at the 6-day mark (it was destroying his sex drive). He actually feels better being off antidepressants, which is strange but... he plans to pay much more attention to his physical and mental health from this point on, including cutting WAY back on stimulant use.

Interestingly, SWIM feels his use of propylhexedrine was causing him more problems than use of MDPV... in particular, he's now pretty sure that eating Benzedrex cotton was responsible for his stomach/intestines going to pot. As far as the depression, SWIM believes the causes were more indirect (e.g. not leading a normal life, hardly ever leaving the house) rather than a direct disruption of brain chemistry. Why? Because it had clearly been coming on for a long time, well before he ever touched MDPV.

[Nagognog2]

I know of one SWIM who has got to have the mother of all cases of cottonmouth. LOL.